DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mcm2 and mcm-3

DIOPT Version :9

Sequence 1:	NP_477121.1	Gene:	Mcm2 / 40973	FlyBaseID:	FBgn0014861	Length:	887	Species:	Drosophila melanogaster
Sequence 2:	NP_506706.1	Gene:	mcm-3 / 180010	WormBaseID:	WBGene00003155	Length:	812	Species:	Caenorhabditis elegans

Alignment Length:	702	Identity:	223/702 - (31%)
Similarity:	351/702 - (50%)	Gaps:	109/702 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   156 IENLEDTKGHSTKEWVSMLGPRTEIANRFQSFLRTFVDERGAYTYRDRIRRMCEQNMSSFVVSYT 220
            |:..||.:             :.||..::.:||....|   .:.||.:|.:|.....|..|::..
Worm    10 IDRAEDAR-------------KQEITEQYLNFLDNQAD---TFHYRQKIVKMMNDGESRLVMNLD 58

  Fly   221 DLAN----------KEHVLAYFLPEAPFQMLEIFDKVAKDMVLSIFPT-----YERVTTEIHVRI 270
            ::..          .:.||.....::..||     .:.:..|.::..|     :|....|.||.
Worm    59 EIREILPERAEGLLTQSVLEMNCLQSALQM-----AINRSDVQAVVKTGFHVGFEGTFGERHVN- 117

  Fly   271 SELPLIEELRTFRKLHLNQLVRTLGVVTATTGVLPQLSVIKYDCVKCGYVL----GPFVQSQNTE 331
               |     ||.:..:|..||...|:||..:.|..:|....:.|.....||    ..|.. .:|.
Worm   118 ---P-----RTLKSSYLGNLVCCEGIVTKCSTVRQKLLTSVHYCPATNKVLEKKFADFTM-LDTA 173

  Fly   332 IKPGSCP-ECQSTGPFSINMEQTLYRNYQKITLQESPGRIPAGRIPRSKDVILLADLCDQCKPGD 395
            :...:.| |.::..|.......::|:::|..|:||.|...|||::||:.|.:...||.|:.||||
Worm   174 VTNNNYPTEDENKNPLETEFGHSVYKDHQTFTIQELPESAPAGQLPRAVDCVADLDLADRVKPGD 238

  Fly   396 ELEVTGIY---TNNYDGSLNTDQGFPVFATVIIANHVVVKDSKQVVQSLTDEDIATIQKLSKDPR 457
            .:.:.|::   .|..:|..:..     |.::||.||:.:. ||:|:.:...:|:..::|:||...
Worm   239 RVRIIGVFRVLPNKQNGVSSGS-----FRSIIIINHIQML-SKEVIPNFEPQDVKDVRKISKSRN 297

  Fly   458 IVERVVASMAPSIYGHDYIKRALALALFGGESKNPGEKHKVRGDINLLICGDPGTAKSQFLKYTE 522
            ..|.:..|:||||.||:..|:||...|.||..|......::|||||:|:.|||..||||.|:|..
Worm   298 PFELLARSLAPSICGHEETKKALLCLLLGGMEKILNNGSRLRGDINVLLIGDPSVAKSQLLRYVL 362

  Fly   523 KVAPRAVFTTGQGASAVGLTAYVRRNPVSREWTLEAGALVLADQGVCLIDEFDKMNDQDRTSIHE 587
            ::||||:.|||:|:|.|||||.|..:|.|.|..|||||:||||:||..|||||||:|.|||:|||
Worm   363 RMAPRAITTTGRGSSGVGLTAAVTTDPDSGERRLEAGAMVLADRGVVCIDEFDKMSDIDRTAIHE 427

  Fly   588 AMEQQSISISKAGIVTSLQARCTVIAAANPIGGRYDPSMTFSENVNLSEPILSRFDVLCVVKDEF 652
            .|||..::||||||...|.|||:|:|||||:.|||:|..:..||:.:.:.:|||||::.|:.||.
Worm   428 VMEQGRVTISKAGIHAKLNARCSVLAAANPVYGRYNPFKSPMENIGMQDSLLSRFDLIFVLLDEH 492

  Fly   653 DPMQDQQLAKFVVHSHMKHHPSEEEQPEL-------------------------EEPQLKTVDE- 691
            |..:|..:|:.|:..|......|.:...|                         |..|...:.:
Worm   493 DADKDANVAEHVLKLHTYRTQGEADGTVLPMGGGVETISTINMETKKASSSIYEENTQWAGIQDT 557

  Fly   692 --IPQDLLRQYIVYAKENIRPKLTNIDEDKIAKMYAQLR--------QESFATGSLPITVRHIES 746
              :..|.:|:||..|: :::||||:...:.|:::||.:|        ||.    ::|:|.|.:|:
Worm   558 KILTMDFMRKYIHLAR-SVQPKLTDEATEYISEVYADIRSFDITKTDQER----TMPVTARQLET 617

  Fly   747 VIRMSEAHARMHLRENVMEADVSMAIRMMLESFIEAQKFSVMKKMRSTFQKY 798
            :||:|.|.|:....:.|...|...|..::        .|:..|:.....|:|
Worm   618 LIRLSTAIAKARFSKKVEREDTEKAYNLL--------HFACFKEKPKARQEY 661

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mcm2	NP_477121.1	MCM2_N	59..166	CDD:372227	3/9 (33%)
		MCM_N	184..270	CDD:379644	19/100 (19%)
		MCM	276..780	CDD:214631	194/547 (35%)
mcm-3	NP_506706.1	MCM_N	25..109	CDD:379644	15/91 (16%)
mcm-3	NP_506706.1	MCM	114..649	CDD:214631	197/563 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1241
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D232729at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820