Protein Alignment Mcm2 and mcm-7

DIOPT Version :10

• Sequence 1: NP_477121.1
• Gene: Mcm2 / 40973
• FlyBaseID: FBgn0014861
• Length: 887
• Species: Drosophila melanogaster
• Sequence 2: NP_504199.1
• Gene: mcm-7 / 178831
• WormBaseID: WBGene00003159
• Length: 730
• Species: Caenorhabditis elegans
• Alignment Length: 779
• Identity: 222/779 - (28%)
• Similarity: 377/779 - (48%)
• Gaps: 166/779 - (21%)

  Fly   169 EWVSMLGPRTEIANRFQSFLRTFVD-ERG---AYTYRDRIRRMCEQNMSSFVVSYTDLANKEHVL 229
            :|.:   .:|:|.:.|..:   :|| |.|   |:.|||::..:..::..:.||      |.:|:.
 Worm     9 DWAA---EKTKIRSFFDEY---YVDNEDGSGKAFPYRDQVFEIARRDKQAIVV------NVDHIK 61

  Fly   230 AYFLPEAPFQMLEI----------FDKVAKDMVLSIFPTYERVTTEIHVRISELPLIEELRT--F 282
            ...:|:|    ||:          ::.:.||.:..:...|        :...:.|:|:.|..  |
 Worm    62 ESDIPDA----LELSEAITSNTKRYEVLFKDTISDMIQDY--------LGDKQAPVIDALDAYMF 114

  Fly   283 RKLHLNQ---------------------------------------------------LVRTLGV 296
            ::||:::                                                   ||...||
 Worm   115 QRLHMDRNEGAANEEVSLQDKRKKYPPQLLQRFEVYFTTDDAAHETCVRNIKATEIGHLVSMKGV 179

  Fly   297 VTATTGVLPQLSVIKYDCVKC---------GYVLGPFVQSQNTEIKPGSCPECQSTGPFSINMEQ 352
            |...|.|.|.:.|:.|.|..|         |....|.|...|.|     |.|.::.|...:.:..
 Worm   180 VIRATEVKPCVEVMTYTCDTCAAEVYQPVKGMQFTPPVNCPNKE-----CVEAKANGRLHMQLRG 239

  Fly   353 TLYRNYQKITLQESPGRIPAGRIPRSKDVILLADLCDQCKPGDELEVTGIYTNNYDGSLNTDQGF 417
            :.:..:|::.:||...::|.|.|||:..|.:..::..:|..|:.:.|:|::............|.
 Worm   240 SKFVKFQELKIQELSEQVPVGSIPRTMTVHVYGEMTRKCNTGNVVHVSGVFLPIMQSGFRPTGGL 304

  Fly   418 PVFATVIIANHVVVKDSKQVVQSLTDEDIATIQKLSKDPRIVERVVASMAPSIYGHDYIKRALAL 482
             |..|.:.|:::...|.......:...::..:::...:   .|.:.||:||.|:||..:|:.|.:
 Worm   305 -VADTYLEAHYINNLDDNPTFNGVQSAELEVLRRKGDN---YETLAASIAPEIFGHVDVKKCLLM 365

  Fly   483 ALFGGESKNPGEKHKVRGDINLLICGDPGTAKSQFLKYTEKVAPRAVFTTGQGASAVGLTAYVRR 547
            ||.|| :.|.....|:||.||:|:.||||.||||.|.|..::|||:.:|||:|:|.|||||.|.:
 Worm   366 ALVGG-NDNSSNGMKIRGCINVLMMGDPGVAKSQLLGYVNRLAPRSQYTTGRGSSGVGLTAAVMK 429

  Fly   548 NPVSREWTLEAGALVLADQGVCLIDEFDKMNDQDRTSIHEAMEQQSISISKAGIVTSLQARCTVI 612
            :||:.|.:||.|||||||.|:|.|||||||.|.|||:|||.||||:|||:||||:|:|.||..:|
 Worm   430 DPVTGEMSLEGGALVLADGGICCIDEFDKMMDHDRTAIHEVMEQQTISIAKAGIMTTLNARTAII 494

  Fly   613 AAANPIGGRYDPSMTFSENVNLSEPILSRFDVLCVVKDEFDPMQDQQLAKFVVHSHMKH--HPSE 675
            |||||..|||:|:.:..:||:|...:|||||::.:::|:.|...|:.||:.:.:.| :|  ||:.
 Worm   495 AAANPAYGRYNPNRSIEQNVDLPAALLSRFDLILLMQDKADRENDKILAEHITYVH-QHGCHPNR 558

  Fly   676 EEQPELEEPQLKTVDEIPQDLLRQYIVYAK---ENIRPKLTNIDEDKIAKMYAQLRQES-FATGS 736
            |::           |.|..:.||:||...|   ..:.|.|    .::|.:.|.::|::: :::..
 Worm   559 EKK-----------DLISLETLREYISLCKTYTPTVDPAL----RERIVEAYVEMRRDARYSSDP 608

  Fly   737 LPITVRHIESVIRMSEAHARMHLRENVMEADVSMAIRMM--LESFIEAQKFSVMKKMRSTFQKYL 799
            ..::.|.|..::||:.|.|::.|...|.|:||..|:|:|  .:..:..::..:.|:|...
 Worm   609 TFVSPRMILGIVRMATARAKLRLSTIVDESDVEEALRLMQFAKDSLRPEQNKIEKRMAPV----- 668

  Fly   800 SFQKDHSELLFFILRQL--------------------TLDQLAYIRCKDGPGATHVEIMERDLI 843
                   :..|.:||:|                    .:.::|..:|.|...|..:.:|:|..|
 Worm   669 -------DAAFAVLRELYHADNAPIAISNAIQRCARKGISEVALKKCLDQYTANGLLVMDRQNI 725

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mcm2	NP_477121.1	MCM2_N	59..166	CDD:403724
		MCM_N	182..271	CDD:464206	20/102 (20%)
		MCM	276..780	CDD:214631	185/573 (32%)
mcm-7	NP_504199.1	MCM_N	14..107	CDD:464206	23/113 (20%)
		MCM	162..651	CDD:475121	180/514 (35%)