Protein Alignment Mcm2 and mcm-2

DIOPT Version :10

• Sequence 1: NP_477121.1
• Gene: Mcm2 / 40973
• FlyBaseID: FBgn0014861
• Length: 887
• Species: Drosophila melanogaster
• Sequence 2: NP_001022416.1
• Gene: mcm-2 / 174841
• WormBaseID: WBGene00003154
• Length: 881
• Species: Caenorhabditis elegans
• Alignment Length: 897
• Identity: 487/897 - (54%)
• Similarity: 633/897 - (70%)
• Gaps: 58/897 - (6%)

  Fly    14 DAAERRDLRAAMTSPVGD---------FEPFENEDEILGDQTVRDEAEEEDGEELFGDNMENDYR 69
            |..:|:.|      |:.|         .|.|.||||         :.|:|:||.||||:||.|||
 Worm     9 DDVDRQPL------PIADDADDDVDGIDEMFNNEDE---------DPEDEEGENLFGDDMERDYR 58

  Fly    70 PMPELDHYDPALLDDEDDFSEMSQGDRFAAESEMRRRDRAAGIHRDDRDLGFGQSDDED-DVGPR 133
            ..||||.|..:.:||..|...:|...|.|||.||.:||:..    ||..|.:...|.|: |...|
 Worm    59 EQPELDQYSESGMDDASDVGSLSVSARRAAEREMAQRDQLL----DDDALMYEDGDSEEVDTRRR 119

  Fly   134 AKRRAGEKAAVGEVEDTEMVE------SIENLEDTKGHSTKEWVSMLGPRTEIANRFQSFLRTFV 192
            .:.|.|.    |:..|.:.|.      .::.||:.:|.:.::.||......||..||::|||:|.
 Worm   120 GRGRRGR----GDAADDDSVPMEEEDIPVDILENIRGRTIRDHVSDEAVAKEIERRFKNFLRSFH 180

  Fly   193 DERGAYT-YRDRIRRMCEQNMSSFVVSYTDLA--NKEHVLAYFLPEAPFQMLEIFDKVAKDMVLS 254
            :.....| |...|:.|...|..|..||:|||:  |.|..::|||||||.:||.|.|:.|.::|::
 Worm   181 EPGNKQTKYIQMIKSMAADNRESLEVSFTDLSDDNGEQNISYFLPEAPNEMLAIMDRAATEVVMN 245

  Fly   255 IFPTYERVTTEIHVRISELPLIEELRTFRKLHLNQLVRTLGVVTATTGVLPQLSVIKYDCVKCGY 319
            ::|.|.||..||.||||:||:.|::|..|::|||.|:||.||||..:|:||||:|:|||||.|||
 Worm   246 MYPFYSRVCNEIKVRISQLPVEEDIRMLRQVHLNMLIRTAGVVTIASGILPQLAVVKYDCVACGY 310

  Fly   320 VLGPFVQSQNTEIKPGSCPECQSTGPFSINMEQTLYRNYQKITLQESPGRIPAGRIPRSKDVILL 384
            :||||||..:.|::|..||.||..|||.:|:|.|:|.|||:||:||||.::.|||:|||||||||
 Worm   311 LLGPFVQQNDEEVRPTICPSCQGKGPFELNVENTVYHNYQRITMQESPNKVAAGRLPRSKDVILL 375

  Fly   385 ADLCDQCKPGDELEVTGIYTNNYDGSLNTDQGFPVFATVIIANHVVVKDSKQVVQSLTDEDIATI 449
            .||||.||||||:||||:||||:|||||..||||||.|:|.|||:..|| |.....||||||..|
 Worm   376 GDLCDSCKPGDEIEVTGVYTNNFDGSLNYKQGFPVFNTLIHANHITNKD-KMASDQLTDEDIKAI 439

  Fly   450 QKLSKDPRIVERVVASMAPSIYGHDYIKRALALALFGGESKNPGEKHKVRGDINLLICGDPGTAK 514
            ::||:||.|.:||.:|:||||||||.:|||:|||||.||:||||.||::|||||:|:||||||||
 Worm   440 RELSQDPNISQRVFSSIAPSIYGHDDVKRAIALALFRGEAKNPGAKHRLRGDINVLLCGDPGTAK 504

  Fly   515 SQFLKYTEKVAPRAVFTTGQGASAVGLTAYVRRNPVSREWTLEAGALVLADQGVCLIDEFDKMND 579
            ||||:|...:|||:|.|||||||||||||||:|:||:|||||||||:||||:|||||||||||:|
 Worm   505 SQFLRYAAHIAPRSVLTTGQGASAVGLTAYVQRHPVTREWTLEAGAMVLADKGVCLIDEFDKMSD 569

  Fly   580 QDRTSIHEAMEQQSISISKAGIVTSLQARCTVIAAANPIGGRYDPSMTFSENVNLSEPILSRFDV 644
            ||||||||||||||||||||||||||.||||||||:|||||||:|:.||:|||:|:|||||||||
 Worm   570 QDRTSIHEAMEQQSISISKAGIVTSLHARCTVIAASNPIGGRYNPTRTFAENVDLTEPILSRFDV 634

  Fly   645 LCVVKDEFDPMQDQQLAKFVVHSHMKHHPSE----EEQPELEEPQLKTVDE------IPQDLLRQ 699
            |||::|..|.::|::||||||.:|..|||..    :|..||||.|:   ||      |||||||:
 Worm   635 LCVIRDSVDSVEDERLAKFVVGNHRTHHPDAKKIVKEGDELEEDQM---DERTGVRLIPQDLLRK 696

  Fly   700 YIVYAKENIRPKLTNIDEDKIAKMYAQLRQESFATGSLPITVRHIESVIRMSEAHARMHLRENVM 764
            ||:||:|...|.|.....:|.:.::||:|:||.||||:.|||||:||:||:|||||::|||..|.
 Worm   697 YIIYAREKCHPTLPEQHSEKFSNIFAQMRKESMATGSVAITVRHVESMIRLSEAHAKLHLRSYVN 761

  Fly   765 EADVSMAIRMMLESFIEAQKFSVMKKMRSTFQKYLSFQKDHSELLFFILRQLTLDQLAYIRCKDG 829
            :.|.:.|||:|||||:..||.|:|:.|:.||.::|:..:..:|||.|||:||...|:.|...:..
 Worm   762 DEDCAAAIRVMLESFVNTQKASIMRMMKKTFSRHLTENRSANELLLFILKQLIRQQMHYATARAA 826

  Fly   830 PGA--THVEIMERDLIERAKQLDIVNLKPFYESDLFRTNGFSYDPKRRIILQ 879
            .|.  ..|.|.|.:.||:|:||.|.|:||||.|::|.:|.|.|||.::.|:|
 Worm   827 AGTILQSVTIPESEFIEKAQQLRIENVKPFYTSEIFASNNFLYDPSKKTIVQ 878

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mcm2	NP_477121.1	MCM2_N	59..166	CDD:403724	41/113 (36%)
		MCM_N	182..271	CDD:464206	40/91 (44%)
		MCM	276..780	CDD:214631	340/513 (66%)
mcm-2	NP_001022416.1	MCM2_N	48..>116	CDD:403724	31/71 (44%)
		MCM_N	169..262	CDD:464206	40/92 (43%)
		MCM	270..777	CDD:214631	339/510 (66%)