DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mcm2 and Mcm7

DIOPT Version :10

Sequence 1:NP_477121.1 Gene:Mcm2 / 40973 FlyBaseID:FBgn0014861 Length:887 Species:Drosophila melanogaster
Sequence 2:NP_032594.1 Gene:Mcm7 / 17220 MGIID:1298398 Length:719 Species:Mus musculus


Alignment Length:699 Identity:227/699 - (32%)
Similarity:364/699 - (52%) Gaps:107/699 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly   183 RFQSFLRTFVDE----RGAYTYRDRIRRMCEQNMSSFVVSYTDLANKEHVLAYFLPEAPFQMLEI 243
            :.:.||:.|..|    :..:.|..::..:..:...:..|...|:|..:..|...:.|...:...:
Mouse    12 KVKKFLQEFYYENELGKKQFKYGTQLVHLAHREQVALYVDLDDIAEDDPELVDSICENAKRYSRL 76

  Fly   244 FDKVAKDMVLSIFPTY---ERVTTEI-HVRISELPLIEE-------------------------- 278
            |.    |:|..:.|.|   |.|..:: .|.|....::|:                          
Mouse    77 FG----DVVQELLPEYKEKEVVNKDVLDVYIEHRLMMEQRSRDPGAVRNPQNQYPSELMRRFELY 137

  Fly   279 -----------LRTFRKLHLNQLVRTLGVVTATTGVLPQLSVIKYDCVKCGYVLGPFVQSQNTEI 332
                       :|..|...:.:|:...|:||..:.|.|::.|..|.|.:||......:||. |.:
Mouse   138 FRGPSSSKPRVIREVRADSVGKLLTVRGIVTRVSEVKPRMVVATYTCDQCGAETYQPIQSP-TFM 201

  Fly   333 KPGSCP--ECQ---STGPFSINMEQTLYRNYQKITLQESPGRIPAGRIPRSKDVILLADLCDQCK 392
            ....||  |||   |.|...:....:.:..:|::.:||...::|.|.||||..|:|..:.....:
Mouse   202 PLIMCPSQECQTNRSGGRLYLQTRGSKFVKFQEMKIQEHSDQVPVGNIPRSITVVLEGENTRIAQ 266

  Fly   393 PGDELEVTGIYTNNYDGSLNTDQGFPVFATVIIAN-----HVVVKDSKQVVQSLTDEDIATIQKL 452
            |||.:.||||:.    ..|.|  ||...|..:::.     |.:||.:|      :|:|::...:|
Mouse   267 PGDHVSVTGIFL----PVLRT--GFQQMAQGLLSETYLEAHWIVKMTK------SDDDVSGAGEL 319

  Fly   453 SK-------DPRIVERVVASMAPSIYGHDYIKRALALALFGGESKNPGEKHKVRGDINLLICGDP 510
            |.       :....|::.||:||.||||:.:|:||.|.|.||..::| :..|:||:|::.:.|||
Mouse   320 SSEELKQIAEEDFYEKLAASIAPEIYGHEDVKKALLLLLVGGVDQSP-QGMKIRGNIHICLMGDP 383

  Fly   511 GTAKSQFLKYTEKVAPRAVFTTGQGASAVGLTAYVRRNPVSREWTLEAGALVLADQGVCLIDEFD 575
            |.||||.|.|.:::|||:.:|||:|:|.|||||.|.|:.||.|.|||.|||||||||||.|||||
Mouse   384 GVAKSQLLSYIDRLAPRSQYTTGRGSSGVGLTAAVLRDSVSGELTLEGGALVLADQGVCCIDEFD 448

  Fly   576 KMNDQDRTSIHEAMEQQSISISKAGIVTSLQARCTVIAAANPIGGRYDPSMTFSENVNLSEPILS 640
            ||.:.|||:|||.||||:|||:||||:|:|.|||:::|||||..|||:|..:..:||.|...:||
Mouse   449 KMAEADRTAIHEVMEQQTISIAKAGILTTLNARCSILAAANPAYGRYNPRRSLEQNVQLPAALLS 513

  Fly   641 RFDVLCVVKDEFDPMQDQQLAKFV--VHSHMKHHPSEEEQPELEEPQLKTVDEIPQDLLRQYIVY 703
            |||:|.:::|..|...|.:||:.:  ||.|.:..|::.|..:::             |:|:||..
Mouse   514 RFDLLWLIQDRPDRDNDLRLAQHITYVHQHSRQPPAQFEPLDMK-------------LMRRYIAM 565

  Fly   704 AKENIRPKLTNIDEDKIAKMYAQLRQESFATGSLPIT-VRHIESVIRMSEAHARMHLRENVMEAD 767
            ..|. :|.:.....|.|...|.::|:|:.|:.....| .|.:.:::|:|.|.||:.:.:.|.:.|
Mouse   566 CHER-QPTVPESLADYITAAYVEMRREARASKDATYTSARTLLAILRLSTALARLRMVDIVEKED 629

  Fly   768 VSMAIRMMLESFIEAQKFSVMKKMRSTFQKYLSFQKDHSELLFFILRQL 816
            |:.|||:|     |..|.|::.:...|.:     .:..::::|..:|:|
Mouse   630 VNEAIRLM-----EMSKDSLLGEKGQTAR-----TQRPADVIFATIREL 668

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Mcm2NP_477121.1 MCM2_N 59..166 CDD:403724
MCM_N 182..271 CDD:464206 18/95 (19%)
MCM 276..780 CDD:214631 201/560 (36%)
Mcm7NP_032594.1 MCM_N 10..103 CDD:464206 18/94 (19%)
MCM 145..641 CDD:214631 201/528 (38%)
Arginine finger 513..516 2/2 (100%)
Interaction with RAD17. /evidence=ECO:0000250 521..564 13/55 (24%)
Interaction with ATRIP. /evidence=ECO:0000250 577..719 27/102 (26%)
Blue background indicates that the domain is not in the aligned region.

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