DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mcm2 and Mcm5

DIOPT Version :9

Sequence 1:	NP_477121.1	Gene:	Mcm2 / 40973	FlyBaseID:	FBgn0014861	Length:	887	Species:	Drosophila melanogaster
Sequence 2:	NP_001289469.1	Gene:	Mcm5 / 17218	MGIID:	103197	Length:	734	Species:	Mus musculus

Alignment Length:	673	Identity:	223/673 - (33%)
Similarity:	357/673 - (53%)	Gaps:	71/673 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   177 RTEIANRFQSFLRTF---VDERG-AYTYRDRIRRMCEQNMSSF--VVSYTDLANKEHVLAYFLPE 235
            ::::..||:.|||.:   .|..| .:.|||.::|  ..|:..:  .|...|||:.:..||..|.:
Mouse    28 KSQLQRRFKEFLRQYRVGTDRTGFTFKYRDELKR--HYNLGEYWIEVEMEDLASFDEELADHLHK 90

  Fly   236 APFQMLEIFDKVAK---DMVLSIFPTYERVTTEIHVRISELPLIEELRTFRKLHLNQLVRTLGVV 297
            .|.:.|::.::.||   |.|....|..:.:..:|.|.:........:|..:...::.||:..|::
Mouse    91 QPAEHLQLLEEAAKEVADEVTRPRPAGDELLQDIQVMLKSDASPSSIRILKSDMMSHLVKIPGII 155

  Fly   298 TATTGVLPQLSVIKYDCVKCGYVLGPFVQSQNTEIKPG--------SC-------PECQSTGPFS 347
            .:.:.|..:.:.|...|..|...|      .|..::||        .|       |:| ...|:.
Mouse   156 ISASAVRAKATRISIQCRSCHNTL------TNIAMRPGLEGYALPRKCNMDQAGRPKC-PLDPYF 213

  Fly   348 INMEQTLYRNYQKITLQESPGRIPAGRIPRSKDVILLADLCDQCKPGDELEVTGIYTNNYDGSLN 412
            |..::....::|.:.|||.|..:|.|.:||...:.....|||:..||:.:.:.|||:....| ||
Mouse   214 IMPDKCKCVDFQTLKLQELPDAVPHGEMPRHMQLYCDRYLCDKVVPGNRVTIMGIYSIKKFG-LN 277

  Fly   413 TDQGFPVFATVIIANHVVV--------KDSKQVVQSLTDEDIATIQKLSKDPRIVERVVASMAPS 469
            ..:|.......|.::::.|        ...:....|::.::....::|:..|.|.|.:..|::||
Mouse   278 PSKGRDRVGVGIRSSYIRVLGIQVDTDGSGRSFAGSVSPQEEEEFRRLAALPNIYELISKSISPS 342

  Fly   470 IYGHDYIKRALALALFGGESKNPGEKHKVRGDINLLICGDPGTAKSQFLKYTEKVAPRAVFTTGQ 534
            |:|...:|:|:|..||||..|...:....|||||||:.|||||||||.||:.||.:|..|:|:|:
Mouse   343 IFGGMDMKKAIACLLFGGSRKRLPDGLTRRGDINLLMLGDPGTAKSQLLKFVEKCSPIGVYTSGK 407

  Fly   535 GASAVGLTAYVRRNPVSREWTLEAGALVLADQGVCLIDEFDKMNDQDRTSIHEAMEQQSISISKA 599
            |:||.||||.|.|:|.||.:.:|.||:||||.||..|||||||.:.||.:||||||||:|||:||
Mouse   408 GSSAAGLTASVIRDPSSRNFIMEGGAMVLADGGVVCIDEFDKMREDDRVAIHEAMEQQTISIAKA 472

  Fly   600 GIVTSLQARCTVIAAANPIGGRYDPSMTFSENVNLSEPILSRFDVLCVVKDEFDPMQDQQLAKFV 664
            ||.|:|.:||:|:||||.:.||:|.:.. .:|::....||||||::.:||||.:..:|..|||.|
Mouse   473 GITTTLNSRCSVLAAANSVFGRWDETKG-EDNIDFMPTILSRFDMIFIVKDEHNEERDMMLAKHV 536

  Fly   665 VHSHMKHHPSEEEQPELEEPQLKTVDEIPQDLLRQYIVYAKENIRPKLTNIDEDKIAKMYAQLR- 728
                |..|.|...|.:..|      .||....::::|.|.:....|:|:....:|:...|..:|
Mouse   537 ----MTLHVSALTQTQAVE------GEIDLAKMKKFIAYCRARCGPRLSAEAAEKLKNRYIIMRS 591

  Fly   729 ------QESFATGSLPITVRHIESVIRMSEAHARMHLRENVMEADVSMAIRMMLESFIEA----- 782
                  ::|....|:|||||.:|:::|::||.::|.|:....||||..|:|:...|.::|
Mouse   592 GARQHERDSDRRSSIPITVRQLEAIVRIAEALSKMKLQPFATEADVEEALRLFQVSTLDAALSGN 656

  Fly   783 ----QKFSVM--KKMRSTFQKYL 799
                :.|:..  ::|.|..:|.|
Mouse   657 LSGVEGFTTQEDQEMLSRIEKQL 679

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mcm2	NP_477121.1	MCM2_N	59..166	CDD:372227
		MCM_N	184..270	CDD:379644	27/94 (29%)
		MCM	276..780	CDD:214631	189/533 (35%)
Mcm5	NP_001289469.1	MCM_N	35..130	CDD:379644	27/96 (28%)
		MCM	133..649	CDD:214631	189/534 (35%)
		Arginine finger	512..515		2/2 (100%)
		BREX_BrxC	<618..>730	CDD:380283	18/62 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1241
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D232729at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820