DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mcm2 and Mcm3

DIOPT Version :9

Sequence 1:	NP_477121.1	Gene:	Mcm2 / 40973	FlyBaseID:	FBgn0014861	Length:	887	Species:	Drosophila melanogaster
Sequence 2:	NP_032589.1	Gene:	Mcm3 / 17215	MGIID:	101845	Length:	812	Species:	Mus musculus

Alignment Length:	692	Identity:	232/692 - (33%)
Similarity:	357/692 - (51%)	Gaps:	90/692 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   179 EIANRFQSFLRTFVDERGAYTYRDRIRRMCEQNMSSFVVSYTDLANKEHVLAYFLPEAPFQMLEI 243
            |:....:.:|....||.....|::::|.:...|....:||..||..|....|..|....|:.|..
Mouse    11 ELREAQRDYLDFLDDEEDQGIYQNKVRELISDNQYRLIVSVNDLRRKNEKRANRLLNNAFEELVA 75

  Fly   244 FDKVAKDMVLSIFPTYERVTTEIHVRISELPLIEELRTFRKLHLNQLVRT---LGVVTATTGVLP 305
            |.:..||.|.||..||.:...|.::.:.        .:|...|::....|   |..|....|::.
Mouse    76 FQRALKDFVASIDATYAKQYEEFYIGLE--------GSFGSKHVSPRTLTSCFLSCVVCVEGIVT 132

  Fly   306 QLSVIKYDCVKCGYV--------------LGPFVQSQNTEIKPGSCPECQSTGPFSINMEQTLYR 356
            :.|:::...|:..:.              |...|...::.:.|   .:.:...|.......::|:
Mouse   133 KCSLVRPKVVRSVHYCPATKKTIERRYSDLTTLVAFPSSSVYP---TKDEENNPLETEYGLSVYK 194

  Fly   357 NYQKITLQESPGRIPAGRIPRSKDVILLADLCDQCKPGDELEVTGIYTNNYDGSLNTDQG---FP 418
            ::|.||:||.|.:.|||::|||.||||..||.|:.||||.::|.|.|.     .|...:|   ..
Mouse   195 DHQTITIQEMPEKAPAGQLPRSVDVILDDDLVDKVKPGDRIQVVGTYR-----CLPGKKGCYTSG 254

  Fly   419 VFATVIIANHVVVKDSKQVVQSLTDEDIATIQKLSK--DPRIVERVVASMAPSIYGHDYIKRALA 481
            .|.||:||.: |.:.||.:..:.:.:|||.|:|.||  ...:.|::..|:||||:||||:|:|:.
Mouse   255 TFRTVLIACN-VKQMSKDIQPAFSADDIAKIKKFSKTRSKDVFEQLARSLAPSIHGHDYVKKAIL 318

  Fly   482 LALFGGESKNPGEKHKVRGDINLLICGDPGTAKSQFLKYTEKVAPRAVFTTGQGASAVGLTAYVR 546
            ..|.||..:.......:|||||:|:.|||..||||.|:|....||||:.|||:|:|.|||||.|.
Mouse   319 CLLLGGVERELENGSHIRGDINILLIGDPSVAKSQLLRYVLCTAPRAIPTTGRGSSGVGLTAAVT 383

  Fly   547 RNPVSREWTLEAGALVLADQGVCLIDEFDKMNDQDRTSIHEAMEQQSISISKAGIVTSLQARCTV 611
            .:..:.|..|||||:||||:||..|||||||:|.|||:|||.|||..::|:||||...|.|||:|
Mouse   384 TDQETGERRLEAGAMVLADRGVVCIDEFDKMSDMDRTAIHEVMEQGRVTIAKAGIHARLNARCSV 448

  Fly   612 IAAANPIGGRYDPSMTFSENVNLSEPILSRFDVLCVVKDEFDPMQDQQLAKFVVHSHMKHHPSEE 676
            :|||||:.||||...|..||:.|.:.:|||||:|.::.|:.||.||::::..|:..|....|.|:
Mouse   449 LAAANPVYGRYDQYKTPMENIGLQDSLLSRFDLLFIMLDQMDPEQDREISDHVLRMHQYRAPGEQ 513

  Fly   677 EQPEL-----------EEPQLKTVDEIPQD-------------------------LLRQYIVYAK 705
            :...|           ::|.....|:  ||                         .:::||..||
Mouse   514 DGDALPLGSSVDILATDDPDFTQDDQ--QDTRIYEKHDSLLHGTKKKKEKMVSAAFMKKYIHVAK 576

  Fly   706 ENIRPKLTNIDEDKIAKMYAQLR-QESFATGSL---PITVRHIESVIRMSEAHARMHLRENVMEA 766
             .|:|.||......||:.|::|| |:|.::.:.   |:|.|.:|::||::.|||:..:.:.|...
Mouse   577 -IIKPTLTQESAAYIAEEYSRLRSQDSMSSDTARTSPVTARTLETLIRLATAHAKARMSKTVDLQ 640

  Fly   767 DVSMAIRMMLESFIEAQKFSVMKKMRSTFQKYLSFQKDHSEL 808
            |.        |..:|..:::..||:....:|.....:|.|:|
Mouse   641 DA--------EEAVELVQYAYFKKVLEKEKKRKKASEDESDL 674

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mcm2	NP_477121.1	MCM2_N	59..166	CDD:372227
		MCM_N	184..270	CDD:379644	24/85 (28%)
		MCM	276..780	CDD:214631	200/565 (35%)
Mcm3	NP_032589.1	MCM_N	17..129	CDD:291233	29/119 (24%)
		MCM	109..654	CDD:214631	200/564 (35%)
		P-loop_NTPase	340..479	CDD:304359	80/138 (58%)
		Arginine finger	477..480		2/2 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	664..744		3/11 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1241
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810