DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mcm2 and mcm-4

DIOPT Version :9

Sequence 1:	NP_477121.1	Gene:	Mcm2 / 40973	FlyBaseID:	FBgn0014861	Length:	887	Species:	Drosophila melanogaster
Sequence 2:	NP_490962.1	Gene:	mcm-4 / 171793	WormBaseID:	WBGene00003156	Length:	823	Species:	Caenorhabditis elegans

Alignment Length:	844	Identity:	252/844 - (29%)
Similarity:	406/844 - (48%)	Gaps:	141/844 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 DEAE-EEDGEELFGDNMENDYRPMPELDHYDPALLDDEDDFSEMSQGDRFAAESEMRRRDRAAGI 112
            |.|| :.:..:||.:         |...|            |.|..|....|.:...|...:|..
Worm     6 DPAEPQSESADLFAE---------PSSQH------------SSMRSGSEQVAGNMSPRSTSSASA 49

  Fly   113 HRDDRDLG-FGQSDDEDDVGPRAKRRAGEKAAVGEVEDTEMVESIENLED-TKGHSTKEWVSMLG 175
            .:...::| ..|......:     ||.|.:..:|..........|..:|| ..|...:..:.:.|
Worm    50 LQYGSEMGSVSQMSSASTL-----RRGGPRGDLGIAAVDHRTVQIRGMEDEMAGDDGQPRLYVWG 109

  Fly   176 PR---TEIANRFQSFLRTF-----VDERGAYTYRDR------------IRRMCEQNMSSFVVSYT 220
            .|   .::...|:.||.||     .::....|..|.            :.|:.|.|.:.  |::.
Worm   110 TRICVADVQRSFRDFLTTFKISQLAEDENMMTGHDEALHEIDVNHPYYMERLLECNDAE--VTHI 172

  Fly   221 DLANKEH-----------VLAYFLPEAPFQMLEIFDKVAKDMVLSIFPTYERVTTEIHVRISELP 274
            :| |.:|           |:||     |..::...|.|..::..      ||....:...|...|
Worm   173 NL-NLKHLNAFSEALYRKVIAY-----PADVIPYLDIVVNEVFA------ERFNRTLAQSIELRP 225

  Fly   275 L-IEELRTFRKLHLN---QLVRTLGVVTATTGVLPQLSVIKYDCVKCGYVLGPFVQSQNTEIKPG 335
            . .::.|..|.|:.|   ||:...|:||.|:.::|::....:.|..|.:.:...|.....| :|.
Worm   226 FNAQKTRNMRGLNPNDVDQLITISGMVTRTSSLIPEMRSGYFQCAVCAFGIESEVDKGRIE-EPV 289

  Fly   336 SCPECQSTGPFSINMEQTLYRNYQKITLQESPGRIPAGRIPRSKDVILLADLCDQCKPGDELEVT 400
            .|..|.:|..|.:...::::.:.|.:.|||||..:|:|..|.:..|.....|.:..:|||.:.||
Worm   290 VCTNCSNTHCFQLVHNRSVFLDKQVVKLQESPDDMPSGETPHTVSVYAHGSLVESVQPGDRITVT 354

  Fly   401 GIY------TNNYDGSLNTDQGFPVFATVIIANHVVVKDSKQVVQ----SLTDEDIATIQKLSKD 455
            ||:      .|....:|.:     |:.|.|.|.|....|:.::.|    ::|:|.|..|.:|||.
Worm   355 GIFRATGMKVNPKQRALAS-----VYRTSIDALHFRKMDTSRLHQDNGETITEERIQQIIELSKR 414

  Fly   456 PRIVERVVASMAPSIYGHDYIKRALALALFGGESKN--PGEKHKVRGDINLLICGDPGTAKSQFL 518
            |.|::.:..|:|||||.||.:||.|...||||..|:  ...|.|:|.:||:|:||||||:|||.|
Worm   415 PDIMDALAQSIAPSIYEHDDVKRGLLCLLFGGTRKDDETTNKTKLRSEINILLCGDPGTSKSQML 479

  Fly   519 KYTEKVAPRAVFTTGQGASAVGLTAYVRRNPVSREWTLEAGALVLADQGVCLIDEFDKMNDQDRT 583
            :|..::.||:.:|:|:|:|||||||.|.|:..:::..|:.|||||||.|||.||||||||:..|:
Worm   480 QYVYRLLPRSQYTSGKGSSAVGLTASVSRDADTKQLVLQTGALVLADNGVCCIDEFDKMNESARS 544

  Fly   584 SIHEAMEQQSISISKAGIVTSLQARCTVIAAANPIGGRYDPSMTFSENVNLSEPILSRFDVLCVV 648
            .:||.||||::||:||||:..|.||.:|:|||||:..:::.:.|..||:.|...:|||||::.::
Worm   545 VLHEVMEQQTLSIAKAGIICQLNARASVLAAANPVDSKWNRNKTIVENITLPHTLLSRFDLIFLI 609

  Fly   649 KDEFDPMQDQQLAKFVVHSHMKHHPSEEEQPELEEPQLKTVDEIPQDLLRQYIVYAKENIRPKLT 713
            .|..|.|||::|...:|..:.::..::|:           .:.:..:|||.||.|||.||.|||:
Worm   610 VDAQDEMQDRRLGNHLVSLYFENDGNQEK-----------TEHVDMNLLRDYIAYAKANIHPKLS 663

  Fly   714 NIDEDKIAKMYAQLRQESFATGSLPITVRHIESVIRMSEAHARMHLRENVMEADVSMAIRMMLES 778
            ......|.:.|..:|:.....|.:....|.:||:||:|||||::.|.:.|...||..|..:..|:
Worm   664 EEASQFIIEKYLFMRKAGAQHGQITAYPRQLESLIRLSEAHAKIRLSQEVSVDDVEKAFTLWREA 728

  Fly   779 F----------------------------IEAQKFSVMKKMRSTFQKYLSFQKDHSELLFFILR 814
            .                            :||...:|:|::: |.:.:::     |:.||..|:
Worm   729 LKQSAVDPSTGRVDVAILASGMSASGRKAVEAMCEAVLKQLK-TAKGFVT-----SKALFHTLK 786

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mcm2	NP_477121.1	MCM2_N	59..166	CDD:372227	20/108 (19%)
		MCM_N	184..270	CDD:379644	22/113 (19%)
		MCM	276..780	CDD:214631	194/546 (36%)
mcm-4	NP_490962.1	MCM_N	121..226	CDD:317013	23/118 (19%)
mcm-4	NP_490962.1	MCM_OB	230..730	CDD:330264	194/516 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1241
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54431
OrthoDB	1	1.010	-	-		D232729at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.830