DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mcm2 and MCMDC2

DIOPT Version :9

Sequence 1:	NP_477121.1	Gene:	Mcm2 / 40973	FlyBaseID:	FBgn0014861	Length:	887	Species:	Drosophila melanogaster
Sequence 2:	NP_775789.3	Gene:	MCMDC2 / 157777	HGNCID:	26368	Length:	681	Species:	Homo sapiens

Alignment Length:	750	Identity:	141/750 - (18%)
Similarity:	260/750 - (34%)	Gaps:	198/750 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   188 LRTFVDERGAY--------TYRDRIRRMCEQNMSSFVVSYTDLANKEHVLAYFLPEAPFQMLEIF 244
            |:.|:|:...|        .||.:|.    .|.|..|....:|.|  |:|     ..|.:..|:|
Human    20 LQKFIDDCKYYNDSKQSYAVYRFKIL----INPSDVVELDAELGN--HIL-----HQPLKAAEVF 73

  Fly   245 DKVAKDMV--LSIFPTYERVTTEIHV--RISELPLIEEL----------RTFRKLHLNQLVRTLG 295
            ..|....|  ||:....: ..|:|::  :::.||.:...          .|.::.::.|     |
Human    74 QSVCFIAVKTLSLIGQLQ-TETQINIVLKLTHLPPLPSYGLDLCEFPLDYTSQRFYMMQ-----G 132

  Fly   296 VVTATTGVLPQLSVIKYDCVKCGYVLGPFVQSQNTEIKPGS-----------CPEC----QSTGP 345
            :|.|.|.:.......::.|......|....|.....: ||:           |..|    |....
Human   133 IVIAMTTITKYTQGARFLCSDEACPLSKGFQYIRVHV-PGATESATIRNDFLCNLCASSLQEDRK 196

  Fly   346 FSINMEQTL--------------YRNYQKITLQESPGRIPAGRIPRSKDVILLADLCDQCKPGDE 396
            |.:..::.:              |.|.|....|             |..:.|..:..::...|:|
Human   197 FRVLGDKQIVEIIATKALRAFQGYSNNQPFRFQ-------------SLTIFLRDESVNKMNIGNE 248

  Fly   397 LEVTGIYTNNYDGSLNTDQGFPVFATVIIANHVVVKDSKQVVQSLTDEDIATIQKLS----KDPR 457
            .::.||.|     .:.|.|    .|..|.||.:...:|| |...::|.....:...|    |...
Human   249 YKIIGIPT-----CVKTSQ----TAVCIEANSITFCNSK-VPSGISDNFRCLLSLTSSSCWKFTA 303

  Fly   458 IVERVVASMAPSIYGHDYIKRALALALFGGESKNPGEKHKVRGDINLLICGDPGTAKSQFLKYTE 522
            |:..:.||.......::.:|..|.::|.....:|    .::...:::||.........:.|.::.
Human   304 ILANIFASQITPPGTYNLLKLCLLMSLVQTTDRN----KELEDCLDILIITSDTLLIDRLLNFSI 364

  Fly   523 KVAPRA--------VFTT------GQGASAVGLTAYVRRNPVSREWTLEAGALVLADQGVCLIDE 573
            .:.||.        :|.|      |.||.::                 :||:.:||..|:|.|.:
Human   365 NLVPRGIRHLVSTEIFPTLSRNKYGTGAVSI-----------------QAGSALLAKGGICFIGD 412

  Fly   574 FDKMNDQDRTSIHEAMEQQSISISKAGIVTSLQARCTVIAAANPIGGRYDPSMTF---------- 628
            ...........:...:|.:||               ||.......|...|..|||
Human   413 LASHKKDKLEQLQTVLESRSI---------------TVYIPGKKFGEDIDQQMTFPVQCSFWSFV 462

  Fly   629 ------SENVNLSEPILSRFDVLCVVKDEFDPMQDQQLAKFVVHSHMKHHPSEEEQPELEEPQLK 687
                  ..|......::.:.|...:      |....:....:::.: :..|.....|.::....|
Human   463 DVDSSSRRNAQKINTLIGQMDCSLI------PANLVEAFGLLINCN-ESSPCHPFLPTVQHTLNK 520

  Fly   688 TVDEIPQDLL----RQY--------IVYAKENIRPKLTNIDEDKIAKMYAQLRQESFATGSL--- 737
            .::  |:.|.    ||:        :.:|| |:..:. :::.:::...| .|......|||:
Human   521 AIN--PEGLFYAASRQFTTEDFEKLLAFAK-NLNVEF-SLEAERMTHGY-YLASRRIRTGSVCGS 580

  Fly   738 PITVRHIESVIRMSEAHARMHLRENVMEADVSMAIRMMLESFIE----AQKFSVMKKMRSTFQKY 798
            .::...::.::.:||||||::||..|::.||.:| .::.|:.:.    |..|.|.......|:.|
Human   581 KLSASALKYLVFLSEAHARLNLRNKVLKEDVLIA-ALLFETSLTLKYGATVFCVAPNAVFPFELY 644

  Fly   799 LSFQKDHSELLFFILRQLTLDQLAYIRCKDGPGAT 833
            .....:..:|.....:|    ||.......|||.|
Human   645 NEEYLEQRDLYLTQCQQ----QLEQFIATYGPGTT 675

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mcm2	NP_477121.1	MCM2_N	59..166	CDD:372227
		MCM_N	184..270	CDD:379644	23/93 (25%)
		MCM	276..780	CDD:214631	103/591 (17%)
MCMDC2	NP_775789.3	PTZ00111	<358..>435	CDD:173403	18/108 (17%)
MCMDC2	NP_775789.3	MCM	<514..622	CDD:278895	26/113 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1241
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900