Protein Alignment Mcm2 and Mcm3

DIOPT Version :10

• Sequence 1: NP_477121.1
• Gene: Mcm2 / 40973
• FlyBaseID: FBgn0014861
• Length: 887
• Species: Drosophila melanogaster
• Sequence 2: XP_322026.3
• Gene: Mcm3 / 1282031
• VectorBaseID: AGAMI1_000046
• Length: 819
• Species: Anopheles gambiae
• Alignment Length: 681
• Identity: 234/681 - (34%)
• Similarity: 352/681 - (51%)
• Gaps: 95/681 - (13%)

  Fly   180 IANRFQSFLRTFVDERGAYTYRDRIRRMCEQNMSSFVVSYTDLANKEHVLAYFLPEAPFQMLEIF 244
            |.|.:.:||.   ||....||...:|:|........||:..|:..|....|..|..:.|.....|
Mosquito    11 IQNEYLNFLD---DEEDQGTYTAHVRKMINDKSKRLVVNINDIRRKNPGRALALLNSAFDEQLAF 72

  Fly   245 DKVAKDMVLSIFPTYERVTTEIHVRISELPLIEELRTFRKLHL---NQLVRTLGVVTATTGVLPQ 306
            .:..||.|.:|..:|.:...:.||...        .:|...|:   :...|.||.:....|::.:
Mosquito    73 SRALKDYVSTIDMSYAKTQEDFHVAFE--------GSFGNKHVTPRSLTSRFLGNLVCVEGIVTK 129

  Fly   307 LSVIKYDCVKCGYVLGP--------FVQSQNTEIKPGSC--PECQSTGPFSINMEQT-----LYR 356
            :|:|:...||..:....        :....:.|..|.|.  |.....|    |:.:|     :|:
Mosquito   130 VSLIRPKVVKSVHYCPATKKVMERRYTDLTSFEAVPSSAVYPTKDDDG----NLLETEFGLSVYK 190

  Fly   357 NYQKITLQESPGRIPAGRIPRSKDVILLADLCDQCKPGDELEVTGIYTNNY------DGSLNTDQ 415
            ::|.:::||.|.:.|||::|||.||:...||.|:|||||.:::.|    ||      .|...|.
Mosquito   191 DHQTLSIQEMPEKAPAGQLPRSVDVVCDDDLVDRCKPGDRVQIVG----NYRCLPGKQGGYTTG- 250

  Fly   416 GFPVFATVIIANHVVVKDSKQVVQSLTDEDIATIQKLSKDPRIVERVVASMAPSIYGHDYIKRAL 480
               .|.|::|||: :.:.:|:...|:|.|:|...:||:|:..|.:.:..|:||||:||:|:|:|:
Mosquito   251 ---TFRTILIANN-ISQLNKESTLSVTREEINMCKKLAKNNDIFDLLAKSLAPSIHGHEYVKKAI 311

  Fly   481 ALALFGGESKNPGEKHKVRGDINLLICGDPGTAKSQFLKYTEKVAPRAVFTTGQGASAVGLTAYV 545
            ...|.||..||.....::|||:|:|:.|||..||||.|:|....||||:.|||:|:|.|||||.|
Mosquito   312 LCLLLGGIEKNLANGTRLRGDVNVLLIGDPSVAKSQLLRYVLNTAPRAITTTGRGSSGVGLTAAV 376

  Fly   546 RRNPVSREWTLEAGALVLADQGVCLIDEFDKMNDQDRTSIHEAMEQQSISISKAGIVTSLQARCT 610
            ..:..:.|..|||||:||||:||..|||||||:|.|||:|||.|||..::||||||..||.|||:
Mosquito   377 TTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDIDRTAIHEVMEQGRVTISKAGIHASLNARCS 441

  Fly   611 VIAAANPIGGRYDPSMTFSENVNLSEPILSRFDVLCVVKDEFDPMQDQQLAKFVVHSHMKHHPSE 675
            |:|||||:.||||...|..||:.|.:.:|||||:|.|:.|..|...|:.::..||..|...:|.|
Mosquito   442 VLAAANPVYGRYDQYKTPMENIGLQDSLLSRFDLLFVMLDVIDSDHDRMISDHVVRMHRYRNPKE 506

  Fly   676 EE---------------------------------QPELEEPQLKTVDEI-PQDLLRQYIVYAKE 706
            ::                                 .|.|.....|..|:| ..:.:|:||..||
Mosquito   507 QDGDVLPMGVSAVDMLSTINPDTLEDKETPMYEKYDPLLHGASRKRTDQILSMEFMRKYIHIAK- 570

  Fly   707 NIRPKLTNIDEDKIAKMYAQLRQESFATGSL----PITVRHIESVIRMSEAHARMHLRENVMEAD 767
            .::||||....:.|:..|::||.:......:    |:|.|.:|::||:|.|||:..:..:|.|.|
Mosquito   571 CLKPKLTETACEMISNEYSRLRSQDLMDSDVARTQPVTARTLETLIRLSTAHAKARMSRSVAEQD 635

  Fly   768 VSMAIRMM----LESFIEAQKFSVMKKMRST 794
            ...||.::    .:..:|.:|    ||.|.|
Mosquito   636 AQAAIELIQFAYFKKVLEKEK----KKRRRT 662

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mcm2	NP_477121.1	MCM2_N	59..166	CDD:403724
		MCM_N	182..271	CDD:464206	24/88 (27%)
		MCM	276..780	CDD:214631	203/569 (36%)
Mcm3	XP_322026.3	None