Protein Alignment Mcm2 and dpa

DIOPT Version :10

• Sequence 1: NP_477121.1
• Gene: Mcm2 / 40973
• FlyBaseID: FBgn0014861
• Length: 887
• Species: Drosophila melanogaster
• Sequence 2: XP_315054.3
• Gene: dpa / 1275768
• VectorBaseID: AGAMI1_003160
• Length: 876
• Species: Anopheles gambiae
• Alignment Length: 918
• Identity: 255/918 - (27%)
• Similarity: 407/918 - (44%)
• Gaps: 205/918 - (22%)

  Fly     5 SSPPPNTPSDAAERRDLRAAMTSPVGDFEPFENEDEILGDQTVRDEAEEEDGEELFGDNMENDYR 69
            ||.|.|..|.|.|..|.....|||..|
Mosquito    43 SSMPTNGASVAIESSDQVTVPTSPAVD-------------------------------------- 69

  Fly    70 PMPELDHYDP----ALLDDEDDFSEMSQGDRFAAESEMRRRDRAAGI---HRDD-------RDLG 120
             .|.|....|    |.:...|..|.::.|...:..|....|....|.   .|.|       |.:.
Mosquito    70 -QPVLQATSPYGRAAGMSQIDISSPLNYGTPSSMGSIRTPRSGVRGTPMRQRPDLRVDKLPRQVN 133

  Fly   121 FGQSDDE-DDVGPRAKRRAGEKAAVGEVEDTEMVESIENLEDTKGHSTKEWVSMLGPR------- 177
            .|.||.. |.:...::..||:                              :...|||
Mosquito   134 VGSSDAHLDPIQEESQASAGD------------------------------IPSSGPRLVVWGTN 168

  Fly   178 ---TEIANRFQSFLRTFVDERGAYTYRDRIRRMCEQNMSSFVVSYTDLANKEHVLAYFLPEAPF- 238
               ||..::|:.|:..::|...|   :|.:......|...::....::    |.|     |.|:
Mosquito   169 VVVTECMSKFKQFILRYIDPNAA---QDELTEGINLNEPLYMQKLEEI----HTL-----EEPYL 221

  Fly   239 ----QMLEIFDKV--------------AKDMVLS--IFPTYERVTTE--IHVRISELPLIEELRT 281
                ..|:.||:.              |.||.::  .|..|.....|  |.||.........:|.
Mosquito   222 NFNCSHLKTFDETLYRQLICYPQDVIPALDMAVNEMFFERYPAAILEHQIQVRPFNADKTRNMRA 286

  Fly   282 FRKLHLNQLVRTLGVVTATTGVLPQLSVIKYDCVKCGYVLGPFVQSQNTEI-KPGSCPECQSTGP 345
            .....::|::...|:|..|:.::|::....:.|..|.:.:  .|:.:...| :|..|..|.:...
Mosquito   287 LNPEDIDQIITISGMVIRTSNIVPEMRCAFFKCSICSFSV--VVELERGRIAEPTLCSHCNTNHC 349

  Fly   346 FSINMEQTLYRNYQKITLQESPGRIPAGRIPRSKDVILLA--DLCDQCKPGDELEVTGIY----- 403
            |.:...::.:.:.|.|.|||||..:.||:.|.  :|:|:|  ||.|:.:|||.:.|||||
Mosquito   350 FQLIHNRSQFADRQLIKLQESPDDMAAGQTPH--NVLLMAHEDLVDKVQPGDRVTVTGIYKAMPI 412

  Fly   404 -TNNYDGSLNTDQGFPVFATVIIANHVVVKDSKQVVQSLTDED-------IATIQKLSKDPRIVE 460
             .|....::.:     |:.|.|...|....|.|::.:....:|       |..::|:::.|.:.:
Mosquito   413 QENPRQSAMKS-----VYRTHIDVLHFRKVDEKRLYEEEEGKDHMFPPERIELLKKIAEKPDVYD 472

  Fly   461 RVVASMAPSIYGHDYIKRALALALFGGESKNPGE--KHKVRGDINLLICGDPGTAKSQFLKYTEK 523
            |:|..:|||||.:..||:.:.|.:|||..|....  :...|.:|::|:||||||:|||.|:|...
Mosquito   473 RLVRCIAPSIYENTDIKKGILLQMFGGSKKKQATSGRQNFRAEIHILMCGDPGTSKSQLLQYVYN 537

  Fly   524 VAPRAVFTTGQGASAVGLTAYVRRNPVSREWTLEAGALVLADQGVCLIDEFDKMNDQDRTSIHEA 588
            :.||..:|:|:|:|||||||||.::..:|:..|:.|||||||.|||.|||||||||..|:.:||.
Mosquito   538 LVPRTQYTSGRGSSAVGLTAYVTKDAETRQLVLQTGALVLADNGVCCIDEFDKMNDSTRSVLHEV 602

  Fly   589 MEQQSISISKAGIVTSLQARCTVIAAANPIGGRYDPSMTFSENVNLSEPILSRFDVLCVVKDEFD 653
            ||||::||:|.||:..|.||.:::|||||...:::.:.|..|||.|...::||||::.::.|..|
Mosquito   603 MEQQTLSIAKVGIICQLNARTSILAAANPSESQWNKNKTIIENVQLPHTLMSRFDLIFLILDPQD 667

  Fly   654 PMQDQQLAKFVVHSHMKHHPSEEEQPELEEPQLKTVDEIPQDLLRQYIVYAKENIRPKLTNIDED 718
            .:.|::||..:|  .|.:...||::..|          :...:||.||.||||:|.|.|:...:.
Mosquito   668 EVFDRRLAAHLV--SMYYATREEDEDTL----------VDMSVLRDYIAYAKEHINPVLSEEAQL 720

  Fly   719 KIAKMYAQLRQESFATGSLPITVRHIESVIRMSEAHARMHLRENVMEADVSMAIRMMLESF---- 779
            ::.::|..:|:.....|.:....|.:||:||:|||||::.|.|.|...||..|.|:..|:.
Mosquito   721 RLIQVYVDMRKVGAGRGQISAYPRQLESLIRLSEAHAKVRLSETVDVQDVEEAWRLHREALKQSA 785

  Fly   780 ------------------IEAQK--FSVMKKMRST-----------FQKYLSFQKDHSELLFFIL 813
                              .||:|  ..|:|.:::.           :||.....||.|::|  |.
Mosquito   786 TDPLSGKIDVGILTTGLSSEARKKRAEVVKSIKANLKAKGKISTIPYQKLFGEIKDGSQVL--IT 848

  Fly   814 RQLTLDQL 821
            :::..|.|
Mosquito   849 KEMFEDAL 856

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mcm2	NP_477121.1	MCM2_N	59..166	CDD:403724	19/121 (16%)
		MCM_N	182..271	CDD:464206	22/111 (20%)
		MCM	276..780	CDD:214631	183/543 (34%)
dpa	XP_315054.3	None