Protein Alignment Mcm2 and Mcm5

DIOPT Version :10

• Sequence 1: NP_477121.1
• Gene: Mcm2 / 40973
• FlyBaseID: FBgn0014861
• Length: 887
• Species: Drosophila melanogaster
• Sequence 2: XP_313694.2
• Gene: Mcm5 / 1274553
• VectorBaseID: AGAMI1_005670
• Length: 733
• Species: Anopheles gambiae
• Alignment Length: 640
• Identity: 231/640 - (36%)
• Similarity: 344/640 - (53%)
• Gaps: 57/640 - (8%)

  Fly   180 IANRFQSFLRTFVDERGAYTYRDRIRRMCEQNMSSFVVSYTDLANKEHVLAYFLPEAPFQMLEIF 244
            :..:::.|:|||.:...:|.|||.::|..........|...|||..:..||..|.:.|.:.|:||
Mosquito    31 VKKQYREFIRTFCEANFSYKYRDTLKRNYLLGRYYLEVEIEDLAGFDESLADKLYKQPTENLQIF 95

  Fly   245 DKVAK---DMVLSIFPTYERVTTEIHVRISELPLIEELRTFRKLHLNQLVRTLGVVTATTGVLPQ 306
            ::.|:   |.:.|..|..|.|..:|.|.:........:|..:...:::||:..|::.|.:|:..:
Mosquito    96 EEAAREVADEITSPRPEGEEVVHDIQVLLVSGANPTNIRDLKSDCVSKLVKVAGIIIAASGIKAK 160

  Fly   307 LSVIKYDCVKCGYVLGPFVQSQNTEIKPG--------SC-------PECQSTGPFSINMEQTLYR 356
            .:.|...|..|..|:      .|..:.||        .|       |:| ...|:.|..::....
Mosquito   161 ATRISIQCRTCNNVI------PNLPVNPGLEGYQLPRKCNTEQAGRPKC-PLDPYFIMPDKCRCV 218

  Fly   357 NYQKITLQESPGRIPAGRIPRSKDVILLADLCDQCKPGDELEVTGIYT-------NNYDGSLNTD 414
            ::|.:.|||.|..||.|.|||...:.....||::..||:.:.:.||::       ...||.....
Mosquito   219 DFQVLKLQELPDFIPQGEIPRHMQLFCDRSLCERVVPGNRVLIHGIFSIRKIARQGKRDGRDKAI 283

  Fly   415 QGF--PVFATVIIANHVVVKDSKQVVQSLTDEDIATIQKLSKDPRIVERVVASMAPSIYGHDYIK 477
            .|.  |....|.|........:.....::|.|:.:|.:||:.:|.|.:.:..|:||||:|...||
Mosquito   284 IGVRAPYMRVVGITVDTEGMGAISRFNNITSEEESTFRKLAANPNIYDTLADSLAPSIFGSQDIK 348

  Fly   478 RALALALFGGESKNPGEKHKVRGDINLLICGDPGTAKSQFLKYTEKVAPRAVFTTGQGASAVGLT 542
            :|:...||||..|...:....|||||:|:.|||||||||.||:.|||||.||:|:|:|:||.|||
Mosquito   349 KAITSMLFGGSRKRMPDGLTRRGDINILLLGDPGTAKSQLLKFVEKVAPIAVYTSGKGSSAAGLT 413

  Fly   543 AYVRRNPVSREWTLEAGALVLADQGVCLIDEFDKMNDQDRTSIHEAMEQQSISISKAGIVTSLQA 607
            |.|.|:|.:|.:.:|.||:||||.||..|||||||.:.||.:||||||||:|||:||||.|:|.:
Mosquito   414 ASVIRDPATRNFIMEGGAMVLADGGVVCIDEFDKMKEDDRVAIHEAMEQQTISIAKAGITTTLNS 478

  Fly   608 RCTVIAAANPIGGRYDPSMTFSENVNLSEPILSRFDVLCVVKDEFDPMQDQQLAKFVVHSHMKHH 672
            ||:|:||||.|.||:|.:.. .||::....||||||::.:||||.|..:|..|||.|:..||...
Mosquito   479 RCSVLAAANSIFGRWDDTKG-DENIDFMPTILSRFDMIFIVKDEHDQQRDITLAKHVMSVHMNAS 542

  Fly   673 PSEEEQPELEEPQLKTVDEIPQDLLRQYIVYAKENIRPKLTNIDEDKIAKMYAQLRQESFATG-- 735
            .:..|..|         .|||..:|::||.|.:.:..|:|.....:|:...|.:||.   ..|
Mosquito   543 KATAEPKE---------GEIPLAMLKKYIHYCRTHCGPRLNEAAAEKLKSQYVRLRA---GVGEH 595

  Fly   736 --------SLPITVRHIESVIRMSEAHARMHLRENVMEADVSMAIRMMLESFIEA 782
                    |:|||||.:|::||:||:.|:|.|:....||.||.|:|:...|.:.|
Mosquito   596 EKAIDKRLSIPITVRQLEAIIRISESLAKMQLQPFATEAHVSEALRLFAVSTMTA 650

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mcm2	NP_477121.1	MCM2_N	59..166	CDD:403724
		MCM_N	182..271	CDD:464206	28/91 (31%)
		MCM	276..780	CDD:214631	202/537 (38%)
Mcm5	XP_313694.2	MCM_N	32..126	CDD:464206	28/93 (30%)
		MCM	129..648	CDD:475121	202/538 (38%)