DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mcm2 and mcm9

DIOPT Version :9

Sequence 1:	NP_477121.1	Gene:	Mcm2 / 40973	FlyBaseID:	FBgn0014861	Length:	887	Species:	Drosophila melanogaster
Sequence 2:	XP_002932153.1	Gene:	mcm9 / 100490403	XenbaseID:	XB-GENE-949288	Length:	1126	Species:	Xenopus tropicalis

Alignment Length:	817	Identity:	236/817 - (28%)
Similarity:	371/817 - (45%)	Gaps:	173/817 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   142 AAVGEVEDTEMVESIENLEDTKGHSTKEWVSMLGPRTEIANRFQSFLRTFVDERGAYTYRDRIRR 206
            |.||:|.::.::|          |..||...:|..:.|.|:
Frog     9 ALVGQVFESFVLE----------HHQKEIAQILTEKYEDAH------------------------ 39

  Fly   207 MCEQNMSSFVVSYTDLANKEHVLAYFLPEAPFQMLEIFDKVAKDMVLSIFPTYERVTT-----EI 266
                  .|.||:...|......:..:....|.::|.|||...:...:|...:.....|     ..
Frog    40 ------YSLVVNAMTLFEANMEIGEYFNAFPNEVLPIFDNALRRAAMSFLQSCSEKQTLVMKQNF 98

  Fly   267 HVRISELPLIEELRTFRKLHLNQLVRTLGVVTATTGVLPQLSVIK-------YDCVKCG------ 318
            |.||:.||:..||   .:.|:.: .|.:|...:.||.:.:.|::|       :.|.||.
Frog    99 HARITGLPVCPEL---TREHIPR-TRDVGHFLSVTGTVIRTSLVKVLEYEQDFMCNKCKHVVTVK 159

  Fly   319 ------YVLGPFVQSQNTEIKPGSCPEC--QSTGPFSINMEQTLYRNYQKITLQESPGRIPAGRI 375
                  |...|.:...|.|....|...|  .|:.|.|.       |:||:|.:||...|:..|.|
Frog   160 ADFEQYYTFKPPITCSNEEGCNSSKFTCLSDSSTPASC-------RDYQEIKIQEQVQRLSVGSI 217

  Fly   376 PRSKDVILLADLCDQCKPGDELEVTGIYTNNYDGSLNTDQGFPVF-------ATVIIANHVVVKD 433
            |||..|:|..||.|.||.||::.|.|:....:.         |::       ..|:.||::.| :
Frog   218 PRSMIVVLEDDLVDSCKSGDDVTVYGVVMQRWK---------PLYIDTRCDLEIVLKANYIAV-N 272

  Fly   434 SKQVVQSLTDEDI-----ATIQKLSKDPRIVE---RVVASMAPSIYGHDYIKRALALALFGGESK 490
            ::|....:.:|::     ...:|....|  :|   .::||:.|.::|...:|.|:|:.|.||..:
Frog   273 NEQPCGVVINEEVRKEYEGFWEKYRNSP--LEGRNEILASLCPQVFGMFVVKLAVAMVLAGGVQR 335

  Fly   491 NPGEKHKVRGDINLLICGDPGTAKSQFLKYTEKVAPRAVFTTGQGASAVGLTAYVRRNPVSREWT 555
            ......:|||:.:||:.|||||.|||||||..|:.||:|.|.|.|:::.|||....::  |.||.
Frog   336 IDSAGTRVRGESHLLLVGDPGTGKSQFLKYAVKITPRSVLTAGIGSTSAGLTVTAVKD--SGEWN 398

  Fly   556 LEAGALVLADQGVCLIDEFDKMNDQDRTSIHEAMEQQSISISKAGIVTSLQARCTVIAAANPIGG 620
            ||||||||||.|:|.||||:.:.:.||||||||||||:||::|||:|..|..|.|::||.|| .|
Frog   399 LEAGALVLADGGLCCIDEFNSIKEHDRTSIHEAMEQQTISVAKAGLVCKLNTRTTILAATNP-KG 462

  Fly   621 RYDPSMTFSENVNLSEPILSRFDVLCVVKDEFDPMQDQQLAKFVVHSHMKHHPSEEEQPELEEPQ 685
            :|||..:.|.||.|:.|:|||||::.|:.|..:...|:.::.|::.|  |..|.:.:       :
Frog   463 QYDPEESISVNVALASPLLSRFDLVLVLLDTKNEDWDRIISSFILES--KGCPRKSD-------K 518

  Fly   686 LKTVDEIPQDLLRQYIVYAKENIRPKLTNIDEDKIAKMYAQLRQESFATGSLPITVRHIESVIRM 750
            |.::::     ::.|....| |::||::. |.:.|...|.||:::|....:...|:|.:||:||:
Frog   519 LWSMEK-----MKTYFCLIK-NLQPKMSQ-DANVILVRYYQLQRQSSCRNAARTTIRLLESLIRL 576

  Fly   751 SEAHARMHLRENVMEADVSMAIRMMLESF--------IEAQKFSVMKKMRSTF------------ 795
            :|||||:..|:.|...|....:.:|..|.        :.|...|..:..|..:
Frog   577 AEAHARLMYRDVVTTEDAITVVSIMESSMQGGALLGGVNALHTSFPENPREQYRMQCELLLERLG 641

  Fly   796 -QKYL--------------SFQKDHSELLFFILRQLT-----LDQLAYIRCK-----DGPGATHV 835
             ||.|              |.:.||.|....|...|.     .|......|.     ..|.||..
Frog   642 LQKLLDKELQRLDRQQNEDSLESDHGESASNISCNLVGHKVHSDSAMEETCSTNETFSSPDATRK 706

  Fly   836 EIMERDLIERAKQLDIVN---LKPFYESDLFRTNGFS 869
            .|  .|:::..|..|.::   :.|..::...||...|
Frog   707 TI--PDILDMTKSDDTISKGTITPAEQNRAIRTQSKS 741

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mcm2	NP_477121.1	MCM2_N	59..166	CDD:372227	5/23 (22%)
		MCM_N	184..270	CDD:379644	12/90 (13%)
		MCM	276..780	CDD:214631	184/547 (34%)
mcm9	XP_002932153.1	MCM_N	15..104	CDD:379644	21/128 (16%)
		MCM_OB	118..244	CDD:379946	40/133 (30%)
		MCM9	306..604	CDD:350666	129/316 (41%)
		NadA	<808..871	CDD:382005
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D232729at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920