Protein Alignment Mcm2 and zmcm3

DIOPT Version :10

• Sequence 1: NP_477121.1
• Gene: Mcm2 / 40973
• FlyBaseID: FBgn0014861
• Length: 887
• Species: Drosophila melanogaster
• Sequence 2: XP_031759909.1
• Gene: zmcm3 / 100158601
• XenbaseID: XB-GENE-971646
• Length: 818
• Species: Xenopus tropicalis
• Alignment Length: 701
• Identity: 232/701 - (33%)
• Similarity: 357/701 - (50%)
• Gaps: 96/701 - (13%)

  Fly   179 EIANRFQSFLRTFVDERGAYTYRDRIRRMCEQNMSSFVVSYTDLANKEHV-----------LAYF 232
            |:....:.:|....|::....|..::|.|...|....:::..|:..|...           |.:.
 Frog    11 ELREAQREYLDFLDDDQDQGLYHGKVRDMIGSNEHRLIINLNDVRRKNEKRANLTNRRYWRLIFR 75

  Fly   233 LPEAPFQMLEIFDKVAKDMVLSIFPTYERVTTEIHV---------RISELPLIEELRTFRKLHLN 288
            |....|.....|.:..||:|.||..||.:...|..|         .:|.       ||.....|.
 Frog    76 LLNNAFGETIAFQRALKDLVASIDATYAKQFEEFSVGFEGSFGSKHVSP-------RTLTASLLG 133

  Fly   289 QLVRTLGVVTATTGVLPQLSVIKYDCVKCGYVL-GPFVQSQNTEIKPGSC---PECQSTGPFSIN 349
            .||...|:||..:.|.|::....:.|......| ..:....:.|..|.|.   .:.:...|....
 Frog   134 SLVCVEGIVTKCSLVRPKVLRSVHYCPATKKTLERKYTDLTSLEAFPSSSIYPTKDEENNPLETE 198

  Fly   350 MEQTLYRNYQKITLQESPGRIPAGRIPRSKDVILLADLCDQCKPGDELEVTGIYTNNYDGSLNTD 414
            ...:.||::|.:::||.|.:.|||::|||.|:|...||.|:|||||.:::.|||.     .|.:.
 Frog   199 YGLSTYRDHQTLSIQEMPEKAPAGQLPRSVDIIADDDLVDKCKPGDRVQIVGIYR-----CLPSK 258

  Fly   415 QG---FPVFATVIIANHVVVKDSKQVVQSLTDEDIATIQKL----SKDPRIVERVVASMAPSIYG 472
            ||   ...|.|:::||::.:. ||::..:.:.:|:|.|:|.    |||  |.|.:..|:||||:|
 Frog   259 QGGFTSGTFRTILLANNIKLM-SKEIAPTFSADDVAKIKKFCKAHSKD--IFEHLSKSLAPSIHG 320

  Fly   473 HDYIKRALALALFGGESKNPGEKHKVRGDINLLICGDPGTAKSQFLKYTEKVAPRAVFTTGQGAS 537
            |:|||:|:...|.||..|......::|||||:|:.|||..||||.|:|....||||:.|||:|:|
 Frog   321 HEYIKKAILCMLLGGNEKVLDNGTRIRGDINVLLIGDPSVAKSQLLRYVLYTAPRAIPTTGRGSS 385

  Fly   538 AVGLTAYVRRNPVSREWTLEAGALVLADQGVCLIDEFDKMNDQDRTSIHEAMEQQSISISKAGIV 602
            .|||||.|..:..:.|..|||||:||||:||..|||||||:|.|||:|||.|||..::|:||||.
 Frog   386 GVGLTAAVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDMDRTAIHEVMEQGRVTIAKAGIQ 450

  Fly   603 TSLQARCTVIAAANPIGGRYDPSMTFSENVNLSEPILSRFDVLCVVKDEFDPMQDQQLAKFVVHS 667
            ..|.|||:|:|||||:.||||...|..||:.|.:.:|||||:|.:|.|:.|...|:::|..|:..
 Frog   451 ARLNARCSVLAAANPVYGRYDQYRTPMENIGLQDSLLSRFDLLFIVLDKMDAENDREIADHVLRM 515

  Fly   668 HMKHHPSEEEQPEL-----------EEPQLKTVDE-----------------------IPQDLLR 698
            |....|.|::...|           ::|....|.:                       :....:|
 Frog   516 HRYRTPGEQDGYALPLGCSVEIFATDDPNASDVTDQELQIYEKHDNLLHGPRKNKSKIVSMQFIR 580

  Fly   699 QYIVYAKENIRPKLTNIDEDKIAKMYAQLRQ----ESFATGSLPITVRHIESVIRMSEAHARMHL 759
            :||..|| .|:|.||....|.|::.||::|.    .:.:..::|:|.|.:|::||::.|||::.:
 Frog   581 KYIHVAK-LIKPVLTPEAADYISQEYAKIRNHDQINNDSARTMPVTARALETMIRLATAHAKVRM 644

  Fly   760 RENVMEADVSMAIRMMLESFIEAQKFSVMKKMRSTFQKYLSFQKD-HSELL 809
            .:.:...|.        |:.:|..:|:..||:.:..:|  ...|| |.|:|
 Frog   645 SKTIERQDA--------ETALELVQFAYFKKVLAKDKK--KTDKDLHDEIL 685

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mcm2	NP_477121.1	MCM2_N	59..166	CDD:403724
		MCM_N	182..271	CDD:464206	21/108 (19%)
		MCM	276..780	CDD:214631	199/552 (36%)
zmcm3	XP_031759909.1	MCM_N	<32..115	CDD:464206	19/82 (23%)
		MCM	120..665	CDD:214631	202/568 (36%)