Protein Alignment Mcm2 and mcm3l

DIOPT Version :10

• Sequence 1: NP_477121.1
• Gene: Mcm2 / 40973
• FlyBaseID: FBgn0014861
• Length: 887
• Species: Drosophila melanogaster
• Sequence 2: NP_001164539.1
• Gene: mcm3l / 100147915
• ZFINID: ZDB-GENE-040121-2
• Length: 807
• Species: Danio rerio
• Alignment Length: 677
• Identity: 235/677 - (34%)
• Similarity: 353/677 - (52%)
• Gaps: 82/677 - (12%)

  Fly   179 EIANRFQSFLRTFVDERGAYTYRDRIRRMCEQNMSSFVVSYTDLANKEHVLAYFLPEAPFQMLEI 243
            |:....:.:|....|::....|.:::|.|........:|:..||..|....|..|.:..|..|..
Zfish     9 ELRESQREYLDFLDDDQDQGIYHEKVRSMVSDGQCRLIVNINDLRRKSEKRAKELLKNAFAELVA 73

  Fly   244 FDKVAKDMVLSIFPTYERVTTEIHV---------RISELPLIEELRTFRKLHLNQLVRTLGVVTA 299
            |.|..||:|.||..||.:...|.||         .:|.       ||.....|..||...|:||.
Zfish    74 FQKALKDLVASIDATYAKQFEEFHVGFEGSFGNKHVSP-------RTLSARFLGNLVCVEGIVTK 131

  Fly   300 TTGVLPQLSVIKYDCVKCGYVL-GPFVQSQNTEIKPGSC---PECQSTGPFSINMEQTLYRNYQK 360
            .:.|.|::....:.|......| ..:....:.:..|.|.   .:.:...|.........|:::|.
Zfish   132 CSLVRPKIMRSVHYCPATKKTLERKYTDLTSLDAFPSSAIYPTKDEENNPLETEFGLCCYKDHQT 196

  Fly   361 ITLQESPGRIPAGRIPRSKDVILLADLCDQCKPGDELEVTGIYTNNYDGSLNTDQG---FPVFAT 422
            :|:||.|.:.|||::|||.|:|...||.|:.||||.:::.|:|.     .|...||   ...|.|
Zfish   197 LTIQEMPEKAPAGQLPRSVDIIANDDLVDRVKPGDRVQIVGVYR-----CLPAKQGGFTSGTFRT 256

  Fly   423 VIIANHVVVKDSKQVVQSLTDEDIATIQKL----SKDPRIVERVVASMAPSIYGHDYIKRALALA 483
            :::||:|.:. ||::|.:.:.:|:|.|:|.    |||  :.|::..|:||||:||:|||:|:...
Zfish   257 ILLANNVKLM-SKEIVPTFSGDDVAKIKKFCKAHSKD--VFEQLSRSLAPSIHGHEYIKKAILCL 318

  Fly   484 LFGGESKNPGEKHKVRGDINLLICGDPGTAKSQFLKYTEKVAPRAVFTTGQGASAVGLTAYVRRN 548
            |.||...|.....::|||||:|:.|||..||||.|:|....||||:.|||:|:|.|||||.|..:
Zfish   319 LLGGNETNLENGTRIRGDINILLIGDPSVAKSQLLRYVLFTAPRAIPTTGRGSSGVGLTAAVTTD 383

  Fly   549 PVSREWTLEAGALVLADQGVCLIDEFDKMNDQDRTSIHEAMEQQSISISKAGIVTSLQARCTVIA 613
            ..:.|..|||||:||||:||..|||||||:|.|||:|||.|||..::||||||...|.|||:|:|
Zfish   384 QETGERRLEAGAMVLADRGVVCIDEFDKMSDMDRTAIHEVMEQGRVTISKAGIQARLNARCSVLA 448

  Fly   614 AANPIGGRYDPSMTFSENVNLSEPILSRFDVLCVVKDEFDPMQDQQLAKFVVHSHMKHHPSEEEQ 678
            ||||:.||||...|..||:.|.:.:|||||:|.:|.|:.||..|:::::.|:..|....|.|.|.
Zfish   449 AANPVYGRYDQYKTPMENIGLQDSLLSRFDLLFIVLDQMDPDSDKEISEHVLRMHRYRAPGEAEG 513

  Fly   679 PEL-----------EEPQLKTVDE-----------------------IPQDLLRQYIVYAKENIR 709
            ..:           |:|.:....|                       :..:.:|:||..|| .::
Zfish   514 TAMPLGSTVDVFATEDPNITEASEQELQIYEKKDNVLHGHRKKREKIVTMEFIRKYIHVAK-LVK 577

  Fly   710 PKLTNIDEDKIAKMYAQLRQ----ESFATGSLPITVRHIESVIRMSEAHARMHLRENVMEADVSM 770
            |.||....|.||:.|::||.    .|.:..::|:|.|.:|::||:|.|||:..:.:.|..||...
Zfish   578 PVLTQEASDYIAEEYSRLRSHDQVNSDSARTMPVTARALETMIRLSTAHAKARMSKTVDLADAEA 642

  Fly   771 AIRMMLESFIEAQKFSVMKKMRSTFQK 797
            |:.:|        :|:..||:....:|
Zfish   643 ALELM--------QFAYFKKILEKVKK 661

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mcm2	NP_477121.1	MCM2_N	59..166	CDD:403724
		MCM_N	182..271	CDD:464206	25/97 (26%)
		MCM	276..780	CDD:214631	204/552 (37%)
mcm3l	NP_001164539.1	MCM_N	29..102	CDD:464206	23/72 (32%)
		MCM	107..652	CDD:214631	206/568 (36%)