DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mcm2 and mcm3l

DIOPT Version :9

Sequence 1:	NP_477121.1	Gene:	Mcm2 / 40973	FlyBaseID:	FBgn0014861	Length:	887	Species:	Drosophila melanogaster
Sequence 2:	NP_001164539.1	Gene:	mcm3l / 100147915	ZFINID:	ZDB-GENE-040121-2	Length:	807	Species:	Danio rerio

Alignment Length:	677	Identity:	235/677 - (34%)
Similarity:	353/677 - (52%)	Gaps:	82/677 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   179 EIANRFQSFLRTFVDERGAYTYRDRIRRMCEQNMSSFVVSYTDLANKEHVLAYFLPEAPFQMLEI 243
            |:....:.:|....|::....|.:::|.|........:|:..||..|....|..|.:..|..|..
Zfish     9 ELRESQREYLDFLDDDQDQGIYHEKVRSMVSDGQCRLIVNINDLRRKSEKRAKELLKNAFAELVA 73

  Fly   244 FDKVAKDMVLSIFPTYERVTTEIHV---------RISELPLIEELRTFRKLHLNQLVRTLGVVTA 299
            |.|..||:|.||..||.:...|.||         .:|.       ||.....|..||...|:||.
Zfish    74 FQKALKDLVASIDATYAKQFEEFHVGFEGSFGNKHVSP-------RTLSARFLGNLVCVEGIVTK 131

  Fly   300 TTGVLPQLSVIKYDCVKCGYVL-GPFVQSQNTEIKPGSC---PECQSTGPFSINMEQTLYRNYQK 360
            .:.|.|::....:.|......| ..:....:.:..|.|.   .:.:...|.........|:::|.
Zfish   132 CSLVRPKIMRSVHYCPATKKTLERKYTDLTSLDAFPSSAIYPTKDEENNPLETEFGLCCYKDHQT 196

  Fly   361 ITLQESPGRIPAGRIPRSKDVILLADLCDQCKPGDELEVTGIYTNNYDGSLNTDQG---FPVFAT 422
            :|:||.|.:.|||::|||.|:|...||.|:.||||.:::.|:|.     .|...||   ...|.|
Zfish   197 LTIQEMPEKAPAGQLPRSVDIIANDDLVDRVKPGDRVQIVGVYR-----CLPAKQGGFTSGTFRT 256

  Fly   423 VIIANHVVVKDSKQVVQSLTDEDIATIQKL----SKDPRIVERVVASMAPSIYGHDYIKRALALA 483
            :::||:|.:. ||::|.:.:.:|:|.|:|.    |||  :.|::..|:||||:||:|||:|:...
Zfish   257 ILLANNVKLM-SKEIVPTFSGDDVAKIKKFCKAHSKD--VFEQLSRSLAPSIHGHEYIKKAILCL 318

  Fly   484 LFGGESKNPGEKHKVRGDINLLICGDPGTAKSQFLKYTEKVAPRAVFTTGQGASAVGLTAYVRRN 548
            |.||...|.....::|||||:|:.|||..||||.|:|....||||:.|||:|:|.|||||.|..:
Zfish   319 LLGGNETNLENGTRIRGDINILLIGDPSVAKSQLLRYVLFTAPRAIPTTGRGSSGVGLTAAVTTD 383

  Fly   549 PVSREWTLEAGALVLADQGVCLIDEFDKMNDQDRTSIHEAMEQQSISISKAGIVTSLQARCTVIA 613
            ..:.|..|||||:||||:||..|||||||:|.|||:|||.|||..::||||||...|.|||:|:|
Zfish   384 QETGERRLEAGAMVLADRGVVCIDEFDKMSDMDRTAIHEVMEQGRVTISKAGIQARLNARCSVLA 448

  Fly   614 AANPIGGRYDPSMTFSENVNLSEPILSRFDVLCVVKDEFDPMQDQQLAKFVVHSHMKHHPSEEEQ 678
            ||||:.||||...|..||:.|.:.:|||||:|.:|.|:.||..|:::::.|:..|....|.|.|.
Zfish   449 AANPVYGRYDQYKTPMENIGLQDSLLSRFDLLFIVLDQMDPDSDKEISEHVLRMHRYRAPGEAEG 513

  Fly   679 PEL-----------EEPQLKTVDE-----------------------IPQDLLRQYIVYAKENIR 709
            ..:           |:|.:....|                       :..:.:|:||..|| .::
Zfish   514 TAMPLGSTVDVFATEDPNITEASEQELQIYEKKDNVLHGHRKKREKIVTMEFIRKYIHVAK-LVK 577

  Fly   710 PKLTNIDEDKIAKMYAQLRQ----ESFATGSLPITVRHIESVIRMSEAHARMHLRENVMEADVSM 770
            |.||....|.||:.|::||.    .|.:..::|:|.|.:|::||:|.|||:..:.:.|..||...
Zfish   578 PVLTQEASDYIAEEYSRLRSHDQVNSDSARTMPVTARALETMIRLSTAHAKARMSKTVDLADAEA 642

  Fly   771 AIRMMLESFIEAQKFSVMKKMRSTFQK 797
            |:.:|        :|:..||:....:|
Zfish   643 ALELM--------QFAYFKKILEKVKK 661

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mcm2	NP_477121.1	MCM2_N	59..166	CDD:372227
		MCM_N	184..270	CDD:379644	25/94 (27%)
		MCM	276..780	CDD:214631	204/552 (37%)
mcm3l	NP_001164539.1	MCM_N	29..127	CDD:291233	29/104 (28%)
		MCM	107..652	CDD:214631	206/568 (36%)
		P-loop_NTPase	338..477	CDD:304359	81/138 (59%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1241
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D232729at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820