DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RpA-70 and RPA70D

DIOPT Version :9

Sequence 1:	NP_524274.1	Gene:	RpA-70 / 40972	FlyBaseID:	FBgn0010173	Length:	603	Species:	Drosophila melanogaster
Sequence 2:	NP_200908.1	Gene:	RPA70D / 836221	AraportID:	AT5G61000	Length:	629	Species:	Arabidopsis thaliana

Alignment Length:	636	Identity:	190/636 - (29%)
Similarity:	320/636 - (50%)	Gaps:	65/636 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 SLSTGVIARIMHGEVVDAP------VLQILAIKKINSAADSERYRILISDGKYFNSYAMLASQLN 63
            |::...|:.::.....|:.      |:|::.:|.|.:     ||....:||| ....||..:.|.
plant     4 SVTPDAISTVLSNPSFDSSSDRSEIVVQVVDLKPIGN-----RYTFSANDGK-TKVKAMFTASLT 62

  Fly    64 VMQHNGELEEFTIVQL-DKYVTSLVGKDGAGKRVLIISEL----TVVNPGAEVKSKIGEPVTYEN 123
            ....:|:::...:::| |..|..:..|   ..:..::::.    :|::....:.||.||....|
plant    63 PEIISGKIQNLGLIRLIDFTVNDISSK---STKYFLVTKCEAVGSVLDSEINLDSKSGEEEARE- 123

  Fly   124 AAKQDLAPKPAVTSNS--------KPIAKKEPSHNNNNNIVMNSSINS------GMT---HPISS 171
            ..||.|...|....|.        ||  |:|....:.:.|:.....|:      .||   ||:.|
plant   124 PKKQKLEHSPVSPLNDVVSTGITLKP--KQEFVAKSASQIMSEQRGNAAPAARMAMTRRVHPLVS 186

  Fly   172 LSPYQNKWVIKARVTSKSGIRTWSNARGEGKLFSMDLMDESG-EIRATAFKEQCDKFYDLIQVDS 235
            |:|||..|.||.|||:|..:|.:.||||||.:|:::|.||.| :|:||.|.:...||:|..|:..
plant   187 LNPYQGNWTIKVRVTNKGVMRNYKNARGEGCVFNVELTDEEGTQIQATMFNDAARKFFDRFQLGK 251

  Fly   236 VYYISKCQLKPANKQYSSLNNAYEMTFSGETVVQLCEDTDDDP-IPEIKYNLVPISDVSGMEN-K 298
            |||||:..||.||||:.::.|.||||.:..:.|:  |.:.::. |||.|:|.|||.::....| |
plant   252 VYYISRGSLKLANKQFKTVQNDYEMTLNENSEVE--EASSEEMFIPETKFNFVPIEELGLYVNQK 314

  Fly   299 AAVDTIGICKEVGELQSFVARTTNKEFKKRDITLVDMSNSAISLTLWGDDAVNFDGHV------Q 357
            ..:|.||:.:.|....|...||.|:...||||||.|.|...:.::||.|.|......:      .
plant   315 ELIDLIGVVQSVSPTMSIRRRTDNEMIPKRDITLADESRKTVVVSLWNDLATGIGQELLDMADQS 379

  Fly   358 PVILVKGTRINEFNGGKSLSLGGGSIMKINPDIPEAHKLRGWFDNGGGDSVANMV------SART 416
            |||.:|..::.:|. |.|||....|.:.|||:.|||.||:.|||:.|.:...:.:      ||:.
plant   380 PVIAIKSLKVGDFQ-GVSLSTISRSNVVINPESPEAKKLKSWFDSEGKEISMSSIGSGMSPSAKN 443

  Fly   417 GGGSFSTEWMTLKDARARNLGSGDKPDYFQCKAVVHIVK-QENAFYRACPQSDCNKKVVDEGNDQ 480
            |..|..|:.:.|....:......:||.:|..:|.:..:| .:..:|:||  ..|||||.:..:..
plant   444 GSRSLYTDRVLLSHITSNPSLFEEKPVFFSTRAYISFIKPDQTMWYQAC--KTCNKKVTEALDSG 506

  Fly   481 FRCEKCNALFPNFKYRLLINMSIGDWTSNRWVSSFNEVGEQLLGHTSQEVGEALENDPAKAEQIF 545
            :.||.|...:.....|.::.:.:.|.:...|:||||:..|::||.::.|:.: |:::..:..:..
plant   507 YWCEGCQRKYEECSLRYIMAVKVTDSSGETWISSFNDEAEKILGCSADELNK-LKSEEGEVNEYQ 570

  Fly   546 SAL---NFTSHIFKLRCKNEVYGDMTRNKLTVQSVAPINHKEYNKHLLKEL 593
            :.|   .::||:|::......|....|.::||:.|||::.....:.||:::
plant   571 TKLKEATWSSHVFRVSVTQNEYNGEKRQRVTVKGVAPLDFAAETRLLLQDI 621

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RpA-70	NP_524274.1	rpa1	3..595	CDD:273177	190/636 (30%)
		Rep-A_N	6..107	CDD:281980	20/111 (18%)
		RPA1_DBD_A	168..270	CDD:239920	50/102 (49%)
		RPA1_DBD_B	301..401	CDD:239921	39/105 (37%)
		Rep_fac-A_C	444..589	CDD:285809	37/148 (25%)
RPA70D	NP_200908.1	rpa1	4..622	CDD:273177	190/636 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	85	1.000	Domainoid score	I2817
eggNOG	1	0.900	-	-		E1_COG1599
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54397
OrthoDB	1	1.010	-	-		D1189265at2759
OrthoFinder	1	1.000	-	-		FOG0002228
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	8	7.790