DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RpA-70 and RPA70B

DIOPT Version :9

Sequence 1:	NP_524274.1	Gene:	RpA-70 / 40972	FlyBaseID:	FBgn0010173	Length:	603	Species:	Drosophila melanogaster
Sequence 2:	NP_196419.1	Gene:	RPA70B / 830696	AraportID:	AT5G08020	Length:	604	Species:	Arabidopsis thaliana

Alignment Length:	628	Identity:	184/628 - (29%)
Similarity:	321/628 - (51%)	Gaps:	69/628 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 SLSTGVIARIMHGEVVDAP------VLQILAIKKINSAADSERYRILISDGKYFNSYAMLASQLN 63
            |::...||.::..:.:|:.      |:|::.:|...:     ||....:||| ....|||.:.|.
plant     4 SVTQDGIATVLANQSLDSSSVRPEIVVQVVDLKPAGN-----RYTFSANDGK-MKIKAMLPATLT 62

  Fly    64 VMQHNGELEEFTIVQLDKY-VTSLVGKDGAGKRVLIISELTVVNPG--AEVKSKIGEPVTYENAA 125
            ....:|:::...:::|.:| |..:.||  :.::.::|::...|...  :|:|::|..........
plant    63 SDIISGKIQNLGLIRLLEYTVNDIPGK--SEEKYMLITKCEAVASALDSEIKAEIKASTGIMLKP 125

  Fly   126 KQDLAPKPA------VTSNSKPIAKKEPSHNNNNNIVMNSSINSGMTHPISSLSPYQNKWVIKAR 184
            |.:...|.|      ...|:.|.|:          :.|...:     ||:.||:|||..|.||.|
plant   126 KHEFVAKSASQIINEQRGNAAPAAR----------MAMTRRV-----HPLVSLNPYQGSWTIKVR 175

  Fly   185 VTSKSGIRTWSNARGEGKLFSMDLMDESG-EIRATAFKEQCDKFYDLIQVDSVYYISKCQLKPAN 248
            ||:|..:||:.||||||.:|:::|.||.| :|:||.|.....||||..::..|||||:..||.||
plant   176 VTNKGVMRTYKNARGEGCVFNVELTDEEGTQIQATMFNAAARKFYDRFEMGKVYYISRGSLKLAN 240

  Fly   249 KQYSSLNNAYEMTFSGETVVQLCEDTDDDPI-PEIKYNLVPISDVSGMEN-KAAVDTIGICKEVG 311
            ||:.::.|.||||.:..:.|:  |.::::.. ||.|:|.|||.::....| |..:|.||:.:.|.
plant   241 KQFKTVQNDYEMTLNENSEVE--EASNEEMFTPETKFNFVPIDELGTYVNQKDLIDVIGVVQSVS 303

  Fly   312 ELQSFVARTTNKEFKKRDITLVDMSNSAISLTLWGDDAVNF--------DGHVQPVILVKGTRIN 368
            ...|...:..|:...||||||.|.:...:.::||.|.|...        |.|  |||.:|..::.
plant   304 PTMSIRRKNDNEMIPKRDITLADETKKTVVVSLWNDLATGIGQELLDMADNH--PVIAIKSLKVG 366

  Fly   369 EFNGGKSLSLGGGSIMKINPDIPEAHKLRGWFDNGGGDSVANMV------SARTGGGSFSTEWMT 427
            .|. |.|||....|.:.|||:.|||.||:.|:|..|.::..:.:      ||..|..|..::.:.
plant   367 AFQ-GVSLSTISRSNVVINPNSPEATKLKSWYDAEGKETSMSAIGSGMSSSANNGSRSMYSDRVF 430

  Fly   428 LKDARAR-NLGSGDKPDYFQCKAVVHIVK-QENAFYRACPQSDCNKKVVDEGNDQFRCEKCNALF 490
            |....:. :||. :||.:|..:|.:..:| .:..:||||  ..|||||.:..:..:.||.|....
plant   431 LSHITSNPSLGE-EKPVFFSTRAYISFIKPDQTMWYRAC--KTCNKKVTEAMDSGYWCESCQKKD 492

  Fly   491 PNFKYRLLINMSIGDWTSNRWVSSFNEVGEQLLGHTSQEVGEALENDPAKAEQIFSAL---NFTS 552
            .....|.::.:.:.|.|...|:|:||:..|:::|.|:.::.: |:::..:..:..:.|   .::|
plant   493 QECSLRYIMAVKVSDSTGETWLSAFNDEAEKIIGCTADDLND-LKSEEGEVNEFQTKLKEATWSS 556

  Fly   553 HIFKLRCKNEVYGDMTRNKLTVQSVAPINHKEYNKHLLKELQE 595
            |:|::....:.|....|.::||:.|:||:.....:.||:::.:
plant   557 HLFRISVSQQEYNSEKRQRITVRGVSPIDFAAETRLLLQDISK 599

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RpA-70	NP_524274.1	rpa1	3..595	CDD:273177	184/626 (29%)
		Rep-A_N	6..107	CDD:281980	23/107 (21%)
		RPA1_DBD_A	168..270	CDD:239920	51/102 (50%)
		RPA1_DBD_B	301..401	CDD:239921	38/107 (36%)
		Rep_fac-A_C	444..589	CDD:285809	37/148 (25%)
RPA70B	NP_196419.1	rpa1	4..599	CDD:273177	184/626 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	85	1.000	Domainoid score	I2817
eggNOG	1	0.900	-	-		E1_COG1599
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54397
OrthoDB	1	1.010	-	-		D1189265at2759
OrthoFinder	1	1.000	-	-		FOG0002228
OrthoInspector	1	1.000	-	-		otm2633
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	8	7.790