DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RpA-70 and Meiob

DIOPT Version :9

Sequence 1:	NP_524274.1	Gene:	RpA-70 / 40972	FlyBaseID:	FBgn0010173	Length:	603	Species:	Drosophila melanogaster
Sequence 2:	NP_083473.1	Gene:	Meiob / 75178	MGIID:	1922428	Length:	470	Species:	Mus musculus

Alignment Length:	479	Identity:	90/479 - (18%)
Similarity:	190/479 - (39%)	Gaps:	79/479 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   169 ISSLSPYQNKWVIKARVTSKSGIRTW---SNARGEGKLFSMDLMDESGE-IRATAFKEQCDKFYD 229
            :|.|.|......|...|..|:.::.:   .|...|...||..:.|.... :..:::..:     |
Mouse    13 LSDLHPNMANLKIIGIVIGKTDVKGFPDRKNIGSERYTFSFTIRDSPCHFVNVSSWGSE-----D 72

  Fly   230 LIQ-VDSVYYISKC--------QLKPANKQYS---SLNNAYEMTFS-GETVVQLCEDTDDD---- 277
            .|: :...:.:::|        |.|...::..   :..:.|::..| ..::|::|...:.|
Mouse    73 YIRSLSESFRVAECVIIENPLIQRKDTEREEKFSPATPSNYKLLLSENHSMVKVCSPYEVDTKLL 137

  Fly   278 -----PIPEIK--YNLVPISDVSGMENKAAVDTIGICKEVGELQSFVARTTNKEFKKRDITLVDM 335
                 |:.|.:  |:|..|.......:...::.:...:.|||.:.|.. :..::.::.::.|.|.
Mouse   138 SLIHLPVKESRDYYSLADIVANGHSLDGRIINVLAAVRSVGEPKYFTT-SDRRKGQRCEVKLFDE 201

  Fly   336 SNSAISLTLWGDDAVNFDGH---VQPVILVKGTRI--NEFNGGKSLSLGGGSIMKINPDIPEAHK 395
            :..:.::|.|.::::.....   .:.||.....||  |:|....:.::...:|:.:|||.|||:.
Mouse   202 TEPSFTMTCWDNESILLAQSWMARETVIFASDVRINFNKFQNCMAATVISKTIITVNPDTPEANI 266

  Fly   396 LRGWFDNGGGDSVANMVSARTGGGSFSTEWM---------TLKDARARNLGSGDKPDYFQCKAVV 451
            |..:.......:||:.:.      |:..|.:         |::..:.:.|.|..|.|.|......
Mouse   267 LLNYIRENKETNVADEID------SYLKESVNLNTIVDVYTVEQLKVKALKSEGKADPFYGILYA 325

  Fly   452 HI----VKQENAFYRACPQSDCNKKVVDEGNDQFRCEKCN-------ALFPNFKYRLLINMSIGD 505
            :|    :..|.........|.|. .:|:|.::  .|..||       :.|.:|.  :|::::  |
Mouse   326 YISTLNIDDETTKVVRNRCSSCG-YIVNEASN--TCTICNQDSSRLKSFFLSFD--VLVDLT--D 383

  Fly   506 WTSNRWVSSFN-EVGEQLLGHTSQEVGEALENDPAKAEQIFSALNFTSHIF-KLRCKNEVYGDMT 568
            .|......|.: .:.|:.||.|..|..........|.:  :..|...|.|: ||...:...|.:
Mouse   384 HTGTLHSCSLSGSIAEETLGCTINEFLTMTSEQKTKLK--WQLLLERSKIYLKLILSHRARGGL- 445

  Fly   569 RNKLTVQSVAPINHKEYNKHLLKE 592
              |:|:.|....:..|.:::|.::
Mouse   446 --KVTILSCKLADPTEASRNLARQ 467

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RpA-70	NP_524274.1	rpa1	3..595	CDD:273177	90/479 (19%)
		Rep-A_N	6..107	CDD:281980
		RPA1_DBD_A	168..270	CDD:239920	19/117 (16%)
		RPA1_DBD_B	301..401	CDD:239921	22/104 (21%)
		Rep_fac-A_C	444..589	CDD:285809	32/157 (20%)
Meiob	NP_083473.1	rpa1	<165..408	CDD:273177	51/256 (20%)
Meiob	NP_083473.1	RPA1_DBD_B	167..269	CDD:239921	22/102 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1599
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810