Protein Alignment RpA-70 and RPA1

DIOPT Version :9

• Sequence 1: NP_524274.1
• Gene: RpA-70 / 40972
• FlyBaseID: FBgn0010173
• Length: 603
• Species: Drosophila melanogaster
• Sequence 2: XP_024306631.1
• Gene: RPA1 / 6117
• HGNCID: 10289
• Length: 618
• Species: Homo sapiens
• Alignment Length: 572
• Identity: 247/572 - (43%)
• Similarity: 355/572 - (62%)
• Gaps: 40/572 - (6%)

  Fly    51 YFNSYAMLASQLNVMQHNGELEEFTIVQLDKYVTSLVGKDGAGKRVLIISELTVVNPGAEVKSKI 115
            :|::: |||:|||.:....:|....:.|:.:::.:.: ||  |:||:|:.||.|:.....|..||
Human    54 WFSAF-MLATQLNPLVEEEQLSSNCVCQIHRFIVNTL-KD--GRRVVILMELEVLKSAEAVGVKI 114

  Fly   116 GEPVTYENAAKQDLAPKPAVTSNSKPIAKKEPSHNNNNNIVMNSSIN------------------ 162
            |.||.|.....|.....||..::  |.|...|...|.:: .|.|:::
Human   115 GNPVPYNEGLGQPQVAPPAPAAS--PAASSRPQPQNGSS-GMGSTVSKAYGASKTFGKAAGPSLS 176

  Fly   163 --SGMTH----PISSLSPYQNKWVIKARVTSKSGIRTWSNARGEGKLFSMDLMDESGEIRATAFK 221
              ||.|.    ||:||:|||:||.|.||||:||.||||||:||||||||::|:|||||||||||.
Human   177 HTSGGTQSKVVPIASLTPYQSKWTICARVTNKSQIRTWSNSRGEGKLFSLELVDESGEIRATAFN 241

  Fly   222 EQCDKFYDLIQVDSVYYISKCQLKPANKQYSSLNNAYEMTFSGETVVQLCEDTDDDPIPEIKYNL 286
            ||.|||:.||:|:.|||.||..||.||||::::.|.|||||:.||.|..||  ||..:|.::::.
Human   242 EQVDKFFPLIEVNKVYYFSKGTLKIANKQFTAVKNDYEMTFNNETSVMPCE--DDHHLPTVQFDF 304

  Fly   287 VPISDVSGMENKAAVDTIGICKEVGELQSFVARTTNKEFKKRDITLVDMSNSAISLTLWGDDAVN 351
            ..|.|:......:.||.|||||...:......|:.|:|..||:|.|:|.|...::.||||:||..
Human   305 TGIDDLENKSKDSLVDIIGICKSYEDATKITVRSNNREVAKRNIYLMDTSGKVVTATLWGEDADK 369

  Fly   352 FDGHVQPVILVKGTRINEFNGGKSLSLGGGSIMKINPDIPEAHKLRGWFDNGG----GDSVANMV 412
            |||..|||:.:||.|:::| ||:|||:...|.:..|||||||:|||||||..|    |.|::::.
Human   370 FDGSRQPVLAIKGARVSDF-GGRSLSVLSSSTIIANPDIPEAYKLRGWFDAEGQALDGVSISDLK 433

  Fly   413 SARTGGGSFSTEWMTLKDARARNLGSGDKPDYFQCKAVVHIVKQENAFYRACPQSDCNKKVVDEG 477
            |...||.  :|.|.||.:.::.|||.|||||||...|.|..:::||..|:|||..||||||:|:.
Human   434 SGGVGGS--NTNWKTLYEVKSENLGQGDKPDYFSSVATVVYLRKENCMYQACPTQDCNKKVIDQQ 496

  Fly   478 NDQFRCEKCNALFPNFKYRLLINMSIGDWTSNRWVSSFNEVGEQLLGHTSQEVGEALENDPAKAE 542
            |..:|||||:..|||||||::::::|.|:..|:||:.|.|..|.:||..:..:||..:.:....|
Human   497 NGLYRCEKCDTEFPNFKYRMILSVNIADFQENQWVTCFQESAEAILGQNAAYLGELKDKNEQAFE 561

  Fly   543 QIFSALNFTSHIFKLRCKNEVYGDMTRNKLTVQSVAPINHKEYNKHLLKELQ 594
            ::|...||.|.||::|.|.|.|.|.:|.|.||..|.|::::||.:.|:..::
Human   562 EVFQNANFRSFIFRVRVKVETYNDESRIKATVMDVKPVDYREYGRRLVMSIR 613

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RpA-70	NP_524274.1	rpa1	3..595	CDD:273177	247/572 (43%)
		Rep-A_N	6..107	CDD:281980	18/55 (33%)
		RPA1_DBD_A	168..270	CDD:239920	70/101 (69%)
		RPA1_DBD_B	301..401	CDD:239921	50/99 (51%)
		Rep_fac-A_C	444..589	CDD:285809	62/144 (43%)
RPA1	XP_024306631.1	rpa1	48..614	CDD:273177	247/572 (43%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155473
Domainoid	1	1.000	145	1.000	Domainoid score	I4593
eggNOG	1	0.900	-	-		E1_COG1599
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2208
Inparanoid	1	1.050	493	1.000	Inparanoid score	I1418
Isobase	1	0.950	-	0	Normalized mean entropy	S1600
OMA	1	1.010	-	-		QHG54397
OrthoDB	1	1.010	-	-		D1189265at2759
OrthoFinder	1	1.000	-	-		FOG0002228
OrthoInspector	1	1.000	-	-		oto91344
orthoMCL	1	0.900	-	-		OOG6_101316
Panther	1	1.100	-	-	LDO	PTHR23273
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2748
SonicParanoid	1	1.000	-	-		X1901
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750