DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RpA-70 and Rpa1

DIOPT Version :9

Sequence 1:	NP_524274.1	Gene:	RpA-70 / 40972	FlyBaseID:	FBgn0010173	Length:	603	Species:	Drosophila melanogaster
Sequence 2:	NP_001380998.1	Gene:	Rpa1 / 287524	RGDID:	1307376	Length:	614	Species:	Rattus norvegicus

Alignment Length:	624	Identity:	270/624 - (43%)
Similarity:	392/624 - (62%)	Gaps:	42/624 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 VLASLSTGVIARIM-HGEVVDAPVLQILAIKKINSAADSERYRILISDGKYFNSYAMLASQLNVM 65
            ::..||.|.||.|| .|:....||||::.|:.|.:.....|||:|:|||....|..|||:|||.:
  Rat     1 MVGHLSEGAIAAIMQQGDTSIKPVLQVINIRPITTGNSPPRYRLLMSDGLNTLSSFMLATQLNAL 65

  Fly    66 QHNGELEEFTIVQLDKYVTSLVGKDGAGKRVLIISELTVVNPGAEVKSKIGEPVTY-ENAAKQDL 129
            ...|:|....:.|:.:::.:.: ||  |:||:|:.:|.||....||..|||.||.| |..|:|..
  Rat    66 VEGGQLASNCVCQVHRFIVNTL-KD--GRRVVILMDLEVVKSAGEVGVKIGNPVPYNEGHAQQQA 127

  Fly   130 APKPAVTSNSKPIAKKEPSHNNNNNIVMNSSI--------------NSGMTH----------PIS 170
            ...|| ::.:.|.:|.:|   .|.::.:.|::              .:|:..          ||:
  Rat   128 VSAPA-SAATPPASKPQP---QNGSLGVGSTVAKAYGASKPFGKPAGTGLLQPTSGTQSKVVPIA 188

  Fly   171 SLSPYQNKWVIKARVTSKSGIRTWSNARGEGKLFSMDLMDESGEIRATAFKEQCDKFYDLIQVDS 235
            ||:|||:||.|.||||:||.||||||:||||||||::|:|||||||||||.||.|||:.||:|:.
  Rat   189 SLTPYQSKWTICARVTNKSQIRTWSNSRGEGKLFSIELVDESGEIRATAFNEQVDKFFPLIEVNK 253

  Fly   236 VYYISKCQLKPANKQYSSLNNAYEMTFSGETVVQLCEDTDDDPIPEIKYNLVPISDVSGMENKAA 300
            |||.||..||.||||:|::.|.|||||:.||.|..||  |...:|.::::...|.|:......:.
  Rat   254 VYYFSKGTLKIANKQFSAVKNDYEMTFNNETSVLPCE--DGHHLPTVQFDFTGIGDLESKSKDSL 316

  Fly   301 VDTIGICKEVGELQSFVARTTNKEFKKRDITLVDMSNSAISLTLWGDDAVNFDGHVQPVILVKGT 365
            ||.|||||...:......::.|:|..||:|.|:|||...::.||||:||..|||..|||:.:||.
  Rat   317 VDIIGICKSYEDATKITVKSNNREVAKRNICLMDMSGKVVTATLWGEDADKFDGSRQPVMAIKGA 381

  Fly   366 RINEFNGGKSLSLGGGSIMKINPDIPEAHKLRGWFDNGG----GDSVANMVSARTGGGSFSTEWM 426
            |:::| ||:|||:...|.:.:|||||||:|||||||:.|    |.|::::.|..|||.  :|.|.
  Rat   382 RVSDF-GGRSLSVLSSSTVLVNPDIPEAYKLRGWFDSEGQALDGVSISDLRSGGTGGS--NTNWK 443

  Fly   427 TLKDARARNLGSGDKPDYFQCKAVVHIVKQENAFYRACPQSDCNKKVVDEGNDQFRCEKCNALFP 491
            ||.:|::.|||.|||.|||...|.|..:::||..|:|||..||||||:|:.|..:|||||:..||
  Rat   444 TLYEAKSENLGQGDKADYFSTVATVVFLRKENCMYQACPTQDCNKKVIDQQNGLYRCEKCDREFP 508

  Fly   492 NFKYRLLINMSIGDWTSNRWVSSFNEVGEQLLGHTSQEVGEALENDPAKAEQIFSALNFTSHIFK 556
            |||||::::::|.|:..|:||:.|.|..|.:||..:..:||..|.:....|::|...||.|..|:
  Rat   509 NFKYRMILSVNIADFQENQWVTCFQESAEAILGQNTVYLGELKEKNEQAFEEVFQNANFRSFTFR 573

  Fly   557 LRCKNEVYGDMTRNKLTVQSVAPINHKEYNKHLLKELQE 595
            :|.|.|.|.|.:|.|.||..|.|:::::|:|.|:..:::
  Rat   574 IRVKLETYNDESRIKATVIDVKPVDYRDYSKRLIMNIRK 612

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RpA-70	NP_524274.1	rpa1	3..595	CDD:273177	270/621 (43%)
		Rep-A_N	6..107	CDD:281980	40/101 (40%)
		RPA1_DBD_A	168..270	CDD:239920	71/101 (70%)
		RPA1_DBD_B	301..401	CDD:239921	50/99 (51%)
		Rep_fac-A_C	444..589	CDD:285809	62/144 (43%)
Rpa1	NP_001380998.1	rpa1	2..612	CDD:273177	270/621 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349357
Domainoid	1	1.000	136	1.000	Domainoid score	I4828
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2208
Inparanoid	1	1.050	493	1.000	Inparanoid score	I1344
OMA	1	1.010	-	-		QHG54397
OrthoDB	1	1.010	-	-		D1189265at2759
OrthoFinder	1	1.000	-	-		FOG0002228
OrthoInspector	1	1.000	-	-		oto98426
orthoMCL	1	0.900	-	-		OOG6_101316
Panther	1	1.100	-	-	LDO	PTHR23273
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1901
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	13	12.910