DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RpA-70 and MEIOB

DIOPT Version :9

Sequence 1:	NP_524274.1	Gene:	RpA-70 / 40972	FlyBaseID:	FBgn0010173	Length:	603	Species:	Drosophila melanogaster
Sequence 2:	NP_001157032.1	Gene:	MEIOB / 254528	HGNCID:	28569	Length:	471	Species:	Homo sapiens

Alignment Length:	389	Identity:	82/389 - (21%)
Similarity:	154/389 - (39%)	Gaps:	57/389 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   186 TSKSGIRTWSNARGEGKLFSMDLMDESGE-IRATAF------KEQCDKFY--DLIQVDSVYYISK 241
            |...|.....|...|...||..:.|.... :.|.::      |...|.|.  |.:.:::. .|.:
Human    33 TDVKGFPDRKNIGSERYTFSFTIRDSPAHFVNAASWGNEDYIKSLSDSFRVGDCVIIENP-LIQR 96

  Fly   242 CQLKPANK-QYSSLNNAYEMTFSGETVVQLCEDTDDD---------PIPEIK--YNLVPISDVSG 294
            .:::...| ..::.:|...:.....:.|::|...:.|         |:.|..  |:|..|.....
Human    97 KEIEREEKFSPATPSNCKLLLSENHSTVKVCSSYEVDTKLLSLIHLPVKESHDYYSLGDIVANGH 161

  Fly   295 MENKAAVDTIGICKEVGELQSFVARTTNKEFKKRDITLVDMSNSAISLTLWGDDAVNFDGHVQP- 358
            ..|...::.:...|.|||.:.|.. :..::.::.::.|.|.:.|:.::|.|.::::.......|
Human   162 SLNGRIINVLAAVKSVGEPKYFTT-SDRRKGQRCEVRLYDETESSFAMTCWDNESILLAQSWMPR 225

  Fly   359 --VILVKGTRIN--EFNGGKSLSLGGGSIMKINPDIPEAHKLRGWFDNGGGDSVAN--------- 410
              ||.....|||  :|....:.::...:|:..|||||||:.|..:.......:|.:
Human   226 ETVIFASDVRINFDKFRNCMTATVISKTIITTNPDIPEANILLNFIRENKETNVLDDEIDSYFKE 290

  Fly   411 MVSARTGGGSFSTEWMTLKDARARNLGSGDKPDYFQCKAVVHIVKQENAFYRA----CPQSDCNK 471
            .::..|....::.|  .||....:|.|..| |.|....|.:..:..::...:.    |  |.|.
Human   291 SINLSTIVDVYTVE--QLKGKALKNEGKAD-PSYGILYAYISTLNIDDETTKVVRNRC--SSCG- 349

  Fly   472 KVVDEGNDQFRCEKCNALFPNFK-----YRLLINMSIGDWTSNRWVSSF-NEVGEQLLGHTSQE 529
            .:|:|.::.  |..||....:||     :.:||:::  |.|......|. ..|.|:.||.|..|
Human   350 YIVNEASNM--CTTCNKNSLDFKSVFLSFHVLIDLT--DHTGTLHSCSLTGSVAEETLGCTVHE 409

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RpA-70	NP_524274.1	rpa1	3..595	CDD:273177	82/389 (21%)
		Rep-A_N	6..107	CDD:281980
		RPA1_DBD_A	168..270	CDD:239920	16/93 (17%)
		RPA1_DBD_B	301..401	CDD:239921	26/104 (25%)
		Rep_fac-A_C	444..589	CDD:285809	23/96 (24%)
MEIOB	NP_001157032.1	RPA1_DBD_B	167..270	CDD:239921	26/103 (25%)
MEIOB	NP_001157032.1	RPA_2b-aaRSs_OBF_like	<345..>421	CDD:299125	21/72 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910