DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9636 and CUEDC2

DIOPT Version :9

Sequence 1:	NP_649774.1	Gene:	CG9636 / 40967	FlyBaseID:	FBgn0037556	Length:	304	Species:	Drosophila melanogaster
Sequence 2:	NP_076945.2	Gene:	CUEDC2 / 79004	HGNCID:	28352	Length:	287	Species:	Homo sapiens

Alignment Length:	299	Identity:	81/299 - (27%)
Similarity:	153/299 - (51%)	Gaps:	28/299 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 MVKRSLVQFISGHIPGADFSVVDEIVLSYIISILEE----ASQDPCFDVEGFVEMMGAYFEEFST 70
            :|..:|:.|:..|:|.||.|.:||::.||::.:||:    ...:..||:|.|.|||.||...|:.
Human     6 IVSAALLAFVQTHLPEADLSGLDEVIFSYVLGVLEDLGPSGPSEENFDMEAFTEMMEAYVPGFAH 70

  Fly    71 IDQGIICDWIYKLANELTDMEKTQENPDAVNLSLNSLSLSSIIPESKLRARNSSTSEKDELSSNS 135
            |.:|.|.|.:.||:.:|:|....:      ||...|..:...:|.|....:.....:::..||.:
Human    71 IPRGTIGDMMQKLSGQLSDARNKE------NLQPQSSGVQGQVPISPEPLQRPEMLKEETRSSAA 129

  Fly   136 SSSGGCGGNKRSQHLSETSDGGSTDSSSSTCDYFLDETEVLQEMFPDSAIAEIKHCIAISKGDID 200
            :::                  .:.|.::...:..|...:||.|:||..::.:.:..:|.::||::
Human   130 AAA------------------DTQDEATGAEEELLPGVDVLLEVFPTCSVEQAQWVLAKARGDLE 176

  Fly   201 SATQILLHRQETNQCITDKSHTTYMKKNVIVDDNELKNRIIARYSYVDKNATQREYKPVVPKMEP 265
            .|.|:|:..:|......:..:....::......:|||:.|:.:|..||....|:.::|:.||..|
Human   177 EAVQMLVEGKEEGPAAWEGPNQDLPRRLRGPQKDELKSFILQKYMMVDSAEDQKIHRPMAPKEAP 241

  Fly   266 RKLVRYRDNKIVSLKGERYTEIKRDEDAELKKPKKQIQP 304
            :||:||.||::||.||||:.:::..|..|:|.....::|
Human   242 KKLIRYIDNQVVSTKGERFKDVRNPEAEEMKATYINLKP 280

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9636	NP_649774.1	CUE_CUED2	169..210	CDD:270550	12/40 (30%)
CUEDC2	NP_076945.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	92..141		8/72 (11%)
CUEDC2	NP_076945.2	CUE_CUED2	147..186	CDD:270550	11/38 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154184
Domainoid	1	1.000	67	1.000	Domainoid score	I9851
eggNOG	1	0.900	-	-		E1_2BVVF
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11430
Inparanoid	1	1.050	136	1.000	Inparanoid score	I4565
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47001
OrthoDB	1	1.010	-	-		D1410219at2759
OrthoFinder	1	1.000	-	-		FOG0008394
OrthoInspector	1	1.000	-	-		oto89043
orthoMCL	1	0.900	-	-		OOG6_109461
Panther	1	1.100	-	-	LDO	PTHR12493
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5269
SonicParanoid	1	1.000	-	-		X6383
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800