Protein Alignment Ada2b and TADA2B

DIOPT Version :9

• Sequence 1: NP_001027151.1
• Gene: Ada2b / 40966
• FlyBaseID: FBgn0037555
• Length: 555
• Species: Drosophila melanogaster
• Sequence 2: NP_689506.2
• Gene: TADA2B / 93624
• HGNCID: 30781
• Length: 420
• Species: Homo sapiens
• Alignment Length: 570
• Identity: 173/570 - (30%)
• Similarity: 251/570 - (44%)
• Gaps: 173/570 - (30%)

  Fly     4 IADLFTKYNCTNCQDDIQGIRVHCAECENFDLCLQCFAAGAEIGAHQNNHSYQFMDTGTSILSVF 68
            :|:|..|| |..|..::..:|..|.||::.:||.:||:||||||.|:..|.||.:|.|...|...
Human     1 MAELGKKY-CVYCLAEVSPLRFRCTECQDIELCPECFSAGAEIGHHRRYHGYQLVDGGRFTLWGP 64

  Fly    69 RGKGAWTAREEIRLLDAIEQYGFGNWEDISKHI-ETKSAEDAKEEYVNKFVNGTIGRATWTPAQS 132
            ..:|.||:|||..|||||||:|||||||::.|: .:::.::..|.||:.:::|.:|:|.......
Human    65 EAEGGWTSREEQLLLDAIEQFGFGNWEDMAAHVGASRTPQEVMEHYVSMYIHGNLGKACIPDTIP 129

  Fly   133 QRPRLIDHTGDDDAGPLGTNALSTLPPLEINSDEAMQLGYMPNRDSFEREYDPTAEQLISNISLS 197
            .  |:.||| ....|||..:..:.||||:|:..|..||||||.||.:|.|||..||.|||.:|::
Human   130 N--RVTDHT-CPSGGPLSPSLTTPLPPLDISVAEQQQLGYMPLRDDYEIEYDQDAETLISGLSVN 191

  Fly   198 SEDTEVDVMLKLAHVDIYTRRLRERARRKRMVRDYQLVSNFF----RNRNYAQQQGLTKEQREFR 258
            .:|.:|::.||.||||:|.|:|:||.|||.:.|||.||..|.    :.:..|.::.:|||::|.|
Human   192 YDDDDVEIELKRAHVDMYVRKLKERQRRKNIARDYNLVPAFLGKDKKEKEKALKRKITKEEKELR 256

  Fly   259 DRFRVYAQFYTCNEYERLLGSLEREKELRIRQSELYRYRYNGLTKIAECTHFEQHAATATHRSTG 323
            .:.|...||.:|.|::.|..::.:||.||.:..||.|||.||:||:.|...:|    .|.|:.
Human   257 LKLRPLYQFMSCKEFDDLFENMHKEKMLRAKIRELQRYRRNGITKMEESAEYE----AARHKR-- 315

  Fly   324 PYGHGKTDHTHTSNGSHRPPSSSLHSPQPNLRKVEMSSGGEASSNSIAPRNTLHIADPTCSGALL 388
                                         ..||
Human   316 -----------------------------EKRK-------------------------------- 319

  Fly   389 PSKNYLDSCRGSSAATMLQTTGMVMGVTVDSGATTGVTSTATTMANLPTNSAKGSQQHLQPLQQH 453
            .:||...|.||..                     .|..|....:.||
Human   320 ENKNLAGSKRGKE---------------------DGKDSEFAAIENL------------------ 345

  Fly   454 PQLLQSGNQHKMQNEAAGGGSDQVPSMSLKLRTQLEELKHLPQPPGSELLSHNELDLCKKHNITP 518
                                                        ||.||||..|..||...|::|
Human   346 --------------------------------------------PGFELLSDREKVLCSSLNLSP 366

  Fly   519 TTYLSVKTVCL-------SGAPS---LGSPMETSLRK----FFIKCGWLS 554
            ..|::|||:.:       .|.||   |.|.::..|:|    |..:.||:|
Human   367 ARYVTVKTIIIKDHLQKRQGIPSKSRLPSYLDKVLKKRILNFLTESGWIS 416

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ada2b	NP_001027151.1	COG5114	10..>341	CDD:227445	134/335 (40%)
		ZZ_ADA2	11..58	CDD:239075	21/46 (46%)
		SANT	73..115	CDD:238096	22/42 (52%)
TADA2B	NP_689506.2	COG5114	6..415	CDD:227445	169/562 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	305..335		10/117 (9%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159469
Domainoid	1	1.000	195	1.000	Domainoid score	I3158
eggNOG	1	0.900	-	-		E1_COG5114
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H51007
Inparanoid	1	1.050	301	1.000	Inparanoid score	I2693
Isobase	1	0.950	-	0	Normalized mean entropy	S4688
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D570949at33208
OrthoFinder	1	1.000	-	-		FOG0001650
OrthoInspector	1	1.000	-	-		oto89724
orthoMCL	1	0.900	-	-		OOG6_100940
Panther	1	1.100	-	-	LDO	PTHR12374
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R21
SonicParanoid	1	1.000	-	-		X4045
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.740