DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ada2b and Tada2b

DIOPT Version :9

Sequence 1:	NP_001027151.1	Gene:	Ada2b / 40966	FlyBaseID:	FBgn0037555	Length:	555	Species:	Drosophila melanogaster
Sequence 2:	XP_038947655.1	Gene:	Tada2b / 289717	RGDID:	1561605	Length:	478	Species:	Rattus norvegicus

Alignment Length:	628	Identity:	172/628 - (27%)
Similarity:	251/628 - (39%)	Gaps:	231/628 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 IADLFTKYNCTNCQDDIQGIRVHCAECENFDLCLQCFAAGAEIGAHQNNHSYQFMDTGTSILSVF 68
            :|:|..|| |..|..::..:|..|.||::.:||.:||:||||||.|:..|.||.:|.|...|...
  Rat     1 MAELGKKY-CVYCLAEVSPLRFRCTECQDIELCPECFSAGAEIGHHRRYHGYQLVDGGRFTLWGP 64

  Fly    69 RGKGAWTAREEIRLLDAIEQYGFGNW--------------------------------------- 94
            ..:|.||:|||..|||||||:|||||
  Rat    65 EAEGGWTSREEQLLLDAIEQFGFGNWGRDLAALSPLPPGICSLFRLSEKQGAKHDPVLSRIFPDV 129

  Fly    95 -------------------EDISKHI-ETKSAEDAKEEYVNKFVNGTIGRATWTPAQSQRPRLID 139
                               ||::.|: .:::.::..|.||:.:::|.:|:|........  |:.|
  Rat   130 VPVANTMAPALQKQWVTLSEDMAAHVGASRTPQEVMEHYVSMYIHGNLGKACIPDTIPN--RVTD 192

  Fly   140 HTGDDDAGPLGTNALSTLPPLEINSDEAMQLGYMPNRDSFEREYDPTAEQLISNISLSSEDTEVD 204
            || ....|||..:..:.||||:|:..|..||||||.||.:|.|||..||.|||.:|::.:|.:|:
  Rat   193 HT-CPSGGPLSPSLTTPLPPLDISVAEQQQLGYMPLRDDYEIEYDQDAETLISGLSVNYDDDDVE 256

  Fly   205 VMLKLAHVDIYTRRLRERARRKRMVRDYQLVSNFF----RNRNYAQQQGLTKEQREFRDRFRVYA 265
            :.||.||||:|.|:|:||.|||.:.|||.||..|.    :.:....::.:|||::|.|.:.|...
  Rat   257 IELKRAHVDMYVRKLKERQRRKNIARDYNLVPAFLGKDKKEKEKTLKRKITKEEKELRLKLRPLY 321

  Fly   266 QFYTCNEYERLLGSLEREKELRIRQSELYRYRYNGLTKIAECTHFEQHAATATHRSTGPYGHGKT 330
            ||.:|.|::.|..::.:||.||.:..||.|||.||:||:.|...:|    .|.|:..
  Rat   322 QFMSCKEFDDLFENMHKEKMLRAKIRELQRYRRNGITKMEESAEYE----AARHKRE-------- 374

  Fly   331 DHTHTSNGSHRPPSSSLHSPQPNLRKVEMSSGGEASSNSIAPRNTLHIADPTCSGALLPSKNYLD 395
                                    |:.|                               :||...
  Rat   375 ------------------------RRKE-------------------------------NKNLAS 384

  Fly   396 SCRGSSAATMLQTTGMVMGVTVDSGATTGVTSTATTMANLPTNSAKGSQQHLQPLQQHPQLLQSG 460
            |.||..                     .|..|....:.||
  Rat   385 SKRGKE---------------------DGKDSEFAAIENL------------------------- 403

  Fly   461 NQHKMQNEAAGGGSDQVPSMSLKLRTQLEELKHLPQPPGSELLSHNELDLCKKHNITPTTYLSVK 525
                                                 ||.||||..|..||...|::|..|::||
  Rat   404 -------------------------------------PGFELLSDREKVLCSSLNLSPARYVTVK 431

  Fly   526 TVCL-------SGAPS---LGSPMETSLRK----FFIKCGWLS 554
            |:.:       .|.||   |.|.::..|:|    |..:.||:|
  Rat   432 TIIIKDHLQKRQGIPSKSRLPSYLDKVLKKRILNFLTESGWIS 474

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ada2b	NP_001027151.1	COG5114	10..>341	CDD:227445	133/393 (34%)
		ZZ_ADA2	11..58	CDD:239075	21/46 (46%)
		SANT	73..115	CDD:238096	22/100 (22%)
Tada2b	XP_038947655.1	COG5114	6..473	CDD:227445	168/620 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353514
Domainoid	1	1.000	192	1.000	Domainoid score	I3111
eggNOG	1	0.900	-	-		E1_COG5114
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H51007
Inparanoid	1	1.050	299	1.000	Inparanoid score	I2628
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D570949at33208
OrthoFinder	1	1.000	-	-		FOG0001650
OrthoInspector	1	1.000	-	-		oto96836
orthoMCL	1	0.900	-	-		OOG6_100940
Panther	1	1.100	-	-	LDO	PTHR12374
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4045
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.760