DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ada2b and ada2

DIOPT Version :9

Sequence 1:	NP_001027151.1	Gene:	Ada2b / 40966	FlyBaseID:	FBgn0037555	Length:	555	Species:	Drosophila melanogaster
Sequence 2:	NP_588011.1	Gene:	ada2 / 2539174	PomBaseID:	SPCC24B10.08c	Length:	437	Species:	Schizosaccharomyces pombe

Alignment Length:	326	Identity:	93/326 - (28%)
Similarity:	162/326 - (49%)	Gaps:	47/326 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 KYNCTNCQDDI-QGIRVHCAECENFDLCLQCFAAGAEIGAHQNNHSYQFMDTGTSILSVFRGKGA 73
            ||:|..|..|| :.|.:.|.||.:||||:.||.:||.:|.|..:|.|:.::|.:  ..:|...
pombe     5 KYHCNVCAQDITRSIHIRCVECVDFDLCIPCFTSGASLGTHHPSHPYRIIETNS--YPIFDEN-- 65

  Fly    74 WTAREEIRLLDAIEQYGFGNWEDISKHI-ETKSAEDAKEEYVNKFVN------------GTIGRA 125
            |.|.||:.|:||.|..|.|||.||:.:: ..::.|:.::.|:..::.            |.:.|.
pombe    66 WGADEELLLIDACETLGLGNWADIADYVGNARTKEECRDHYLKTYIESDCYPLASVELPGPVDRI 130

  Fly   126 TWTPAQSQR------PRLIDHTGDDDAGPLGTNALSTLPPLEINSDEAMQLGYMPNRDSFEREYD 184
            .:...:..|      |.:|...      ||.    ||....||.       ||||.|..|::||.
pombe   131 AFAARKRARIEAFQPPPIIPQK------PLA----STPQCHEIQ-------GYMPGRLEFDQEYM 178

  Fly   185 PTAEQLISNISLSS---EDTEVDVMLKLAHVDIYTRRLRERARRKRMVRDYQLVSNFFRNRNYAQ 246
            ..||..|.:::...   |..:.::.|||..::||..||..||.||:.:.::.|:.  :| |..|.
pombe   179 NEAELPIKDMNFDDDLHESAKHEMQLKLTMLNIYNSRLTRRAVRKQTIFNHNLLD--YR-RLQAN 240

  Fly   247 QQGLTKEQREFRDRFRVYAQFYTCNEYERLLGSLEREKELRIRQSELYRYRYNGLTKIAECTHFE 311
            ::.::||:|...::.:.:|:..|..:|::.:.|...:..|:.:.|:|..:|..|||.:.:...:|
pombe   241 EKRMSKEERNLLNKTKAFARLLTGPDYQKFVNSYHEQITLKKQISDLQEWRQMGLTTLEQGHKYE 305

  Fly   312 Q 312
            :
pombe   306 R 306

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ada2b	NP_001027151.1	COG5114	10..>341	CDD:227445	93/326 (29%)
		ZZ_ADA2	11..58	CDD:239075	21/47 (45%)
		SANT	73..115	CDD:238096	16/42 (38%)
ada2	NP_588011.1	COG5114	1..437	CDD:227445	93/326 (29%)
		ZZ_ADA2	6..54	CDD:239075	21/47 (45%)
		Myb_DNA-binding	65..108	CDD:278669	16/44 (36%)
		SWIRM	357..433	CDD:282311
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	52	1.000	Domainoid score	I3323
eggNOG	1	0.900	-	-		E1_COG5114
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	137	1.000	Inparanoid score	I1386
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001650
OrthoInspector	1	1.000	-	-		oto101137
orthoMCL	1	0.900	-	-		OOG6_100940
Panther	1	1.100	-	-	O	PTHR12374
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R21
SonicParanoid	1	1.000	-	-		X4045
TreeFam	1	0.960	-	-
	12	11.850