DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ada2b and tada2b

DIOPT Version :9

Sequence 1:	NP_001027151.1	Gene:	Ada2b / 40966	FlyBaseID:	FBgn0037555	Length:	555	Species:	Drosophila melanogaster
Sequence 2:	XP_012811175.1	Gene:	tada2b / 100488628	XenbaseID:	XB-GENE-991340	Length:	420	Species:	Xenopus tropicalis

Alignment Length:	570	Identity:	172/570 - (30%)
Similarity:	248/570 - (43%)	Gaps:	173/570 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 IADLFTKYNCTNCQDDIQGIRVHCAECENFDLCLQCFAAGAEIGAHQNNHSYQFMDTGTSILSVF 68
            :|||..|| |..|..|:..:|:.|.||::.:||..||:||||||.|:..|.||.:|.|...|...
Frog     1 MADLSKKY-CVYCLADVTSLRLRCTECQDIELCTDCFSAGAEIGNHRRWHGYQLVDGGRFTLWGP 64

  Fly    69 RGKGAWTAREEIRLLDAIEQYGFGNWEDISKHI-ETKSAEDAKEEYVNKFVNGTIGRATWTPAQS 132
            ..:|.||:|||..|||||||:|||||||::.|: .:::..:..|.||..:::|.:|:|. .| .|
Frog    65 EAEGGWTSREEQLLLDAIEQFGFGNWEDMAAHVGASRTPTEVMEHYVTMYIHGNLGKAC-IP-DS 127

  Fly   133 QRPRLIDHTGDDDAGPLGTNALSTLPPLEINSDEAMQLGYMPNRDSFEREYDPTAEQLISNISLS 197
            ...|:.||| ....|||..:..:.||||::...:..||||||.||.:|.|||..||.|||.:|::
Frog   128 IPNRVTDHT-CPTGGPLSPSLTTPLPPLDLTVADQQQLGYMPLRDDYEIEYDQDAETLISGLSVN 191

  Fly   198 SEDTEVDVMLKLAHVDIYTRRLRERARRKRMVRDYQLVSNFF----RNRNYAQQQGLTKEQREFR 258
            .:|.:|:|.||.|:||:|.|:|:||.|||.:.|||.||..|.    ::::...::.::||::|.|
Frog   192 YDDDDVEVELKEAYVDMYVRKLKERQRRKNIARDYNLVPAFLGKDKKDKDKPAKRKISKEEKELR 256

  Fly   259 DRFRVYAQFYTCNEYERLLGSLEREKELRIRQSELYRYRYNGLTKIAECTHFEQHAATATHRSTG 323
            .:.|...||.:..|.|....::.:|:.||.:..||.|||.||:||:.|...:|    .|.|:.
Frog   257 LKLRPLYQFMSNKEIEDFFENMHKERMLRAKIRELQRYRRNGITKMEESAEYE----AARHKR-- 315

  Fly   324 PYGHGKTDHTHTSNGSHRPPSSSLHSPQPNLRKVEMSSGGEASSNSIAPRNTLHIADPTCSGALL 388
                                         ..||
Frog   316 -----------------------------EKRK-------------------------------- 319

  Fly   389 PSKNYLDSCRGSSAATMLQTTGMVMGVTVDSGATTGVTSTATTMANLPTNSAKGSQQHLQPLQQH 453
            .:||...|.||..                     .|..|....:.||
Frog   320 ENKNTASSKRGRE---------------------DGKESEFAAIENL------------------ 345

  Fly   454 PQLLQSGNQHKMQNEAAGGGSDQVPSMSLKLRTQLEELKHLPQPPGSELLSHNELDLCKKHNITP 518
                                                        .|.||||..|..||...|::|
Frog   346 --------------------------------------------AGFELLSDREKVLCSSLNLSP 366

  Fly   519 TTYLSVKTVCL-------SGAPS---LGSPMETSLRK----FFIKCGWLS 554
            |.||:|||:.:       .|.||   |.|.::..|:|    |..:.||:|
Frog   367 TRYLTVKTIIIKDHLQKRQGIPSKSRLPSYLDKVLKKRILNFLTESGWIS 416

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ada2b	NP_001027151.1	COG5114	10..>341	CDD:227445	131/335 (39%)
		ZZ_ADA2	11..58	CDD:239075	22/46 (48%)
		SANT	73..115	CDD:238096	22/42 (52%)
tada2b	XP_012811175.1	COG5114	6..415	CDD:227445	167/562 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	143	1.000	Domainoid score	I4625
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H51007
Inparanoid	1	1.050	251	1.000	Inparanoid score	I3143
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D570949at33208
OrthoFinder	1	1.000	-	-		FOG0001650
OrthoInspector	1	1.000	-	-		oto103536
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R21
SonicParanoid	1	1.000	-	-		X4045
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.090