DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DNApol-iota and Polh

DIOPT Version :9

Sequence 1:	NP_001287227.1	Gene:	DNApol-iota / 40965	FlyBaseID:	FBgn0037554	Length:	737	Species:	Drosophila melanogaster
Sequence 2:	NP_109640.1	Gene:	Polh / 80905	MGIID:	1891457	Length:	694	Species:	Mus musculus

Alignment Length:	686	Identity:	162/686 - (23%)
Similarity:	278/686 - (40%)	Gaps:	148/686 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 RTIIHLDMDYFYAQVEEIRDPTLRSKALGIQQKNI-----VVTCNYVARAKGVTKLMLIAEAQRI 74
            |.:..:|||.|:.|||:.::|.||:|...:.|...     ::..:|.|||.|||:.|...:|:::
Mouse     7 RVVALVDMDCFFVQVEQRQNPHLRNKPCAVVQYKSWKGGGIIAVSYEARAFGVTRNMWADDAKKL 71

  Fly    75 CPDLVLVNGED------LAPYRQMSQRIFDLLLNYTPLVEKLGFDENFMDVTALVELR----QAH 129
            ||||:|....:      |..||:.|..:.: :::|..::|:...||.::|:|:.|:.|    |..
Mouse    72 CPDLLLAQVRESRGKANLTKYREASVEVME-IMSYFAVIERASIDEAYIDLTSAVQERLQKLQGQ 135

  Fly   130 VAEALLRPPVGHTYPADGTP-------------------------LSNCDCGCAQ-RLAIGTRIA 168
            ...|.|.|   .|| .:|.|                         |.:.|..... ||.:|..|.
Mouse   136 PISADLLP---STY-IEGLPRGPTVEETVQKEAIRKQGLLQWLDSLQSDDPTSPDLRLTVGAMIV 196

  Fly   169 QEIREELKLRLGITCCAGIAYNKLLAKLVGSSHEPNQQTVLVSTYAEQFMRELGDLKRVTGIGQK 233
            :|:|..::.:.|..|.|||::||:||||....::||:||::......|...:: .::::..:|.|
Mouse   197 EEMRAAIESKTGFQCSAGISHNKVLAKLACGLNKPNRQTLVSHGSVPQLFSQM-PIRKIRSLGGK 260

  Fly   234 TQCLLLEA-GMSSVEQLQQCDMDVMRKKFGFETATRLRDLAFGRDTSLVRPSGKPKTIGMEDACK 297
            ....::|. |:..:..|.|.....::..||.:..:.|..:..|.:...|:|...|||||    |.
Mouse   261 LGASVIEVLGIEYMGDLTQFTESQLQSHFGEKNGSWLYAMCRGIEHDPVKPRQLPKTIG----CS 321

  Fly   298 -------PISVRTDVEERFRMLLKRLVEQVAED----GRVPIAIKVVLRKFDSQKKSSHRETKQA 351
                   .::.|..|:.....|...|.|::.:|    .||...:.|.:|....::.||.|   :.
Mouse   322 KNFPGKTALATREQVQWWLLQLALELEERLTKDRNDNDRVATQLVVSIRFQGDRRLSSLR---RC 383

  Fly   352 NILPSLFKTSMCPGETGVSKVQLADGAQDKLLKIVMRLFERIVDMSKPFNITLLGLAFSKFQ-ER 415
            ..||......|........:.....|.|              .:.|.|  :|:|.|..:||. ..
Mouse   384 CALPRYDAHKMSQDAFAAIRNCNTSGIQ--------------TEWSPP--LTMLFLCATKFSAAA 432

  Fly   416 KVGSSSIANFLIKKADLE--VQSITSLTNTSLTSPTAESPTSDECAFRSSPTTFKPSDQFYRRRA 478
            ....:.|..||...:..:  |...:|.|.|..:.|..  |||.|.| .|..:.|:.:.:..|.:.
Mouse   433 PPACTDITAFLSSDSSCQPKVPIASSETRTQGSGPAV--PTSKEAA-TSLASFFQKAAKKQRMKE 494

  Fly   479 TTASPV----------PMLLDNGSESAATNSDFSDFSETEVEPSPKKSRIGRLLVSKRSRLAADV 533
            |:..|:          |.|:...|::..:.|.|.           :||.:  |..::.|..||..
Mouse   495 TSFVPLNTATEKLSSKPSLVFQSSQTTGSQSFFK-----------QKSLL--LQHTQLSNSAAPD 546

  Fly   534 GDSAAEVASPSKLRVCDLRLNSRDSEKDFPMSTTPSTSTSAPAPRFRTVQPPNTLLQRIDGSLRF 598
            ...|:..|.||    | |.....||..|                               ||:::.
Mouse   547 PPQASPAAQPS----C-LPAECVDSGPD-------------------------------DGAVKP 575

  Fly   599 VTTRTASRLSSNASSTASSPLPSPMDDSIAMSAPST 634
            |:::..| ...|.:..:.:.|.||..:|..::..:|
Mouse   576 VSSKAVS-TEMNVAGDSPNVLDSPAYNSQEVTQRAT 610

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DNApol-iota	NP_001287227.1	PolY_Pol_iota	18..411	CDD:176457	111/445 (25%)
Polh	NP_109640.1	DinP	7..>325	CDD:223466	89/327 (27%)
		PolY_Pol_eta	10..427	CDD:176456	111/445 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	565..598		9/64 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	651..694
		PIP-box. /evidence=ECO:0000250\|UniProtKB:Q9Y253	682..689
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0389
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001835
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4551
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.840