DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DNApol-iota and poli

DIOPT Version :9

Sequence 1:	NP_001287227.1	Gene:	DNApol-iota / 40965	FlyBaseID:	FBgn0037554	Length:	737	Species:	Drosophila melanogaster
Sequence 2:	NP_001027479.2	Gene:	poli / 613070	XenbaseID:	XB-GENE-943046	Length:	742	Species:	Xenopus tropicalis

Alignment Length:	776	Identity:	265/776 - (34%)
Similarity:	374/776 - (48%)	Gaps:	126/776 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LGKS-EAHQRTIIHLDMDYFYAQVEEIRDPTLRSKALGIQQKNIVVTCNYVARAKGVTKLMLIAE 70
            :|:| .:..|.|:|:|||.||||||.||:|.||:|.||||||.|||||||.||..||||||||.:
Frog    41 VGRSGTSASRVIVHIDMDCFYAQVEMIRNPELRNKPLGIQQKYIVVTCNYEARKFGVTKLMLIKD 105

  Fly    71 AQRICPDLVLVNGEDLAPYRQMSQRIFDLLLNYTPLVEKLGFDENFMDVTALVELRQAHVAEALL 135
            |:..||.||||:||||.|||:||.|..:||..::|.||:||||||::|||.||:.:.........
Frog   106 AREKCPQLVLVSGEDLTPYREMSYRATELLEEFSPQVERLGFDENYIDVTELVDKKLQEERGNGR 170

  Fly   136 RPPV-GHTYPADGTPLSNCDCGCAQRLAIGTRIAQEIREELKLRLGITCCAGIAYNKLLAKLVGS 199
            .|.| ||.|   .....|.:.....|:|.|:.||.|||..|..|||:|.|||.|.||||||||..
Frog   171 NPGVCGHVY---SDQKMNVNDWAHVRIAAGSHIASEIRAALYNRLGLTGCAGTASNKLLAKLVSG 232

  Fly   200 SHEPNQQTVLVSTYAEQFMRELGDLKRVTGIGQKTQCLLLEAGMSSVEQLQQCDMDVMRKKFGFE 264
            :|:|||||.|:.......:..|..:||:.|||.||...|...|:|.:..||.|.:.::.|:||..
Frog   233 THKPNQQTALLHESHSHLINSLDHVKRIPGIGYKTSKRLESLGLSRISDLQACPITLLEKEFGSS 297

  Fly   265 TATRLRDLAFGRDTSLVRPSGKPKTIGMEDA---CKPIS-VRTDVEERFRMLLKRLVEQVAEDGR 325
            .|.|::.|:.|.|.|.|.|||.|::|..||:   |..:| |:..:|||.|.||.|    :::|||
Frog   298 VAHRIQMLSRGEDDSAVVPSGPPQSISDEDSFKKCSTVSEVKIKMEERLRNLLVR----ISKDGR 358

  Fly   326 VPIAIKVVLRKFDSQKKSSHRETKQANILPSLFKTSMCPGETGVSK-VQLADGAQDKLLKIVMRL 389
            :|..:::.:|:|....|..:||::|            ||....:|: :.....|...|::::|||
Frog   359 IPHTLRLTIRQFSPSNKWFNRESRQ------------CPIPAHISQNIGAECQAVPALMELLMRL 411

  Fly   390 FERIVDMSKPFNITLLGLAFSKFQERKVGSSSIANFLIKKA--------------------DLEV 434
            ||:::|:...|::|||.:.||..:......|||..:|..||                    ...:
Frog   412 FEKMIDVKMQFHLTLLNVCFSNLKASNSTRSSIGFYLTLKAPPAAATPLKGSTEAEQHTAESFPL 476

  Fly   435 QSITSLTNT---SLTSPTAESPTSDECAFRSSPTTFKPSDQFYRRRATTASPVPMLLDN----GS 492
            :..:|..:|   |:..|||..||:......:.|....|.         ..|.:|..:..    |.
Frog   477 KENSSAPHTAPQSVGQPTAPVPTNHHTMLETLPEGIDPE---------VFSQLPEEIQQEIIAGQ 532

  Fly   493 ESAATNSDFSDFSETEVEPSPKKSRIGRLLVSKRSRLAADVGDSAAEVASPSKLRVCDLRLNSRD 557
            ..||.:|..|..|.::.:.:|.|   |.|....|:: |||:         ||:   ||..|....
Frog   533 RHAAASSSSSVRSASKSQAAPPK---GILNFFSRAK-AADL---------PSQ---CDGVLLKEH 581

  Fly   558 SEKDFPMSTTPSTSTSAP---APRFRTVQPPNTLLQRIDGSL------------RFVTTRTASRL 607
            |:       |...||.||   :..|    |...:..|..|||            .:.|.::|.|.
Frog   582 SQ-------TNRGSTEAPQGASSNF----PKGVVDVRPTGSLWDPKQEMHPFGQSYDTDQSAERC 635

  Fly   608 SSNASSTASSPLPSPMDDSIAMSAPSTTTLPFPSPTTTAVVTSSSSTATCDALTNIVCPAGVDAE 672
            .:.|         .|| ||...|:.|...||..|............       .....|..||..
Frog   636 GTTA---------EPM-DSCCSSSTSCGQLPPQSAEMECAKAGGDQ-------ERAPFPHSVDVN 683

  Fly   673 VFKELPVELQTELIASWRSSLVAAVEQTNGTGAATSAAIASGAPATATTASGQKNTLYRYF 733
            ||.:||.|:|.||:|.|:.     ::.|........:..|..:....|.||...::|.:||
Frog   684 VFSQLPEEVQRELMAEWKQ-----LKPTPKIPVRKQSEKAKASRGKRTGASAGASSLLKYF 739

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DNApol-iota	NP_001287227.1	PolY_Pol_iota	18..411	CDD:176457	177/398 (44%)
poli	NP_001027479.2	PolY	53..433	CDD:330231	177/398 (44%)
poli	NP_001027479.2	DUF4414	<492..>534	CDD:316865	10/50 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	178	1.000	Domainoid score	I3519
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	329	1.000	Inparanoid score	I2417
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1593931at2759
OrthoFinder	1	1.000	-	-		FOG0001835
OrthoInspector	1	1.000	-	-		oto102984
Panther	1	1.100	-	-	LDO	PTHR46404
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X5102
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	9.070