DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DNApol-iota and Rev1

DIOPT Version :9

Sequence 1:	NP_001287227.1	Gene:	DNApol-iota / 40965	FlyBaseID:	FBgn0037554	Length:	737	Species:	Drosophila melanogaster
Sequence 2:	XP_006496219.1	Gene:	Rev1 / 56210	MGIID:	1929074	Length:	1264	Species:	Mus musculus

Alignment Length:	819	Identity:	169/819 - (20%)
Similarity:	281/819 - (34%)	Gaps:	238/819 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 SVLGKSEAHQRTIIHLDMDYFYAQV------------------------------------EEIR 33
            ||| .|..||..::|:|||.|:..|                                    :..:
Mouse   421 SVL-SSPRHQSCVMHVDMDCFFVSVGIRNRPDLKGKPVAVTSNRGTGTAPLRPGANPQLEWQYYQ 484

  Fly    34 DPTLRSKALGIQQKNI--------------------VVTCNYVARAKGVTKLMLIAEAQRICPDL 78
            :..||.||..|...::                    :.:|:|.||..|:...|....|:::||:|
Mouse   485 NRALRGKAADIPDSSVWENQDSTQTNGIDSVLSKAEIASCSYEARQVGIKNGMFFGYAKQLCPNL 549

  Fly    79 VLVNGEDLAPY-----RQMSQRIFDLLLNYTPLVEKLGFDENFMDVTALVELRQAHVAEALLRPP 138
            ..|      ||     |:::|.:::.|.:||..:|.:..||..:|||.:       :||..|.|
Mouse   550 QAV------PYDFHACREVAQAMYETLASYTHSIEAVSCDEALIDVTDI-------LAETKLSP- 600

  Fly   139 VGHTYPADGTPLSNCDCGCAQRLAIGTRIAQEIREELKLRLGITCCA--GIAYNKLLAKLVGSSH 201
                                :..|...||  ||:::.|      |.|  ||..|.|||::.....
Mouse   601 --------------------EEFAAALRI--EIKDKTK------CAASVGIGSNILLARMATKKA 637

  Fly   202 EPNQQTVLVSTYAEQFMRELGDL-KRVTGIGQKTQCLLLEAGMSSVEQLQQCDMDVMRKKFGFET 265
            :|:.|..|.....:.|:|  |.| ..:.|:|:..:..|...|:.:...||...|..::|:||.:|
Mouse   638 KPDGQYHLQPDEVDDFIR--GQLVTNLPGVGRSMESKLASLGIKTCGDLQCLTMAKLQKEFGPKT 700

  Fly   266 ATRLRDLAFGRDTSLVRPSGKPKTIGMEDACKPISVR-TDVEERFRMLL------KRLVEQVAED 323
            ...|.....|.|...||...:.|::..|   ....:| |..:|....||      :|.:|.....
Mouse   701 GQMLYRFCRGLDDRPVRTEKERKSVSAE---INYGIRFTQPKEAEAFLLSLSEEIQRRLEAAGMK 762

  Fly   324 GRVPIAIKVVLRK----FDSQKKSSHRETKQANILPSLFKTSMCPGETGVSKVQLADGAQDKLLK 384
            |: .:.:|:::||    .::.|...|                               |..|.:.:
Mouse   763 GK-RLTLKIMVRKPGAPIETAKFGGH-------------------------------GICDNIAR 795

  Fly   385 IVMRLFERIVDMSKPFNITLLGLA-FSKFQERKVGSSSIANFLIKKADLEVQSITSLTNTSLTSP 448
            .|  ..::..|.:|     ::|.| .:.|...|:..|.     ::...::|..:.. .|::| |.
Mouse   796 TV--TLDQATDSAK-----IIGKATLNMFHTMKLNISD-----MRGVGIQVNQLVP-ANSNL-ST 846

  Fly   449 TAESPTSDECAFRSSPTTFKPSDQFYRRRATT--------ASPVPMLLDNGSESAATNSDFSDFS 505
            .:..|::....|...|.:.:...|..:.:..|        .:.|.:.:.:.|.:....|..|...
Mouse   847 CSSRPSAQSSLFSGRPHSVRDLFQLQKAKKPTEEEHKEVFLAAVDLEVSSTSRACGLLSPLSAHL 911

  Fly   506 ETEVEPSPKKSRIGRLL------VSKRSRLAADVGDSAAEVASPSKLRVCDLRLNSRDSEKDFPM 564
            ...|.|........|..      ||.:|||...:     ||.|||::....|.....|..:....
Mouse   912 AASVSPDTNSGECSRKWNGLHSPVSGQSRLNLSI-----EVPSPSQIDQSVLEALPLDLREQIEQ 971

  Fly   565 STTPSTSTSAPAPRFRTVQPPNTLLQRIDGSLRFVTTRTASRLSSNASSTASSPLPSPMDDSIAM 629
                ..:.....||.:..:|.|                          ..:|..||.|:
Mouse   972 ----VCAAQQGEPRGKKKEPVN--------------------------GCSSGVLPHPV------ 1000

  Fly   630 SAPSTTTLPFPSPTTTAVVTSSSSTATCDALTNIVCPAGVDAEVFKELPVELQTELIASW----R 690
               .|..|..|.|.......|..|.....|.:.      ||.:||..||.|||.||.|::    |
Mouse  1001 ---GTVLLQIPEPQEPCNSDSKISVIALPAFSQ------VDPDVFAALPAELQKELKAAYDQRQR 1056

  Fly   691 SSLVAAVEQTNGTGAATSAAIASGAPATATTASGQKNTL 729
            .......:|...|....:..:....||.....:.:||.:
Mouse  1057 QGEDTTHQQPTSTSVPKNPLLQLKPPAMKDKRNKRKNLI 1095

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DNApol-iota	NP_001287227.1	PolY_Pol_iota	18..411	CDD:176457	98/468 (21%)
Rev1	XP_006496219.1	BRCT_Rev1	63..146	CDD:349351
		PolY_Rev1	361..837	CDD:176455	108/507 (21%)
		DUF4414	948..>969	CDD:373035	5/20 (25%)
		Rev1_C	1170..1263	CDD:213388
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0389
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810