Protein Alignment DNApol-iota and POLH

DIOPT Version :9

• Sequence 1: NP_001287227.1
• Gene: DNApol-iota / 40965
• FlyBaseID: FBgn0037554
• Length: 737
• Species: Drosophila melanogaster
• Sequence 2: NP_006493.1
• Gene: POLH / 5429
• HGNCID: 9181
• Length: 713
• Species: Homo sapiens
• Alignment Length: 572
• Identity: 134/572 - (23%)
• Similarity: 250/572 - (43%)
• Gaps: 102/572 - (17%)

  Fly    15 RTIIHLDMDYFYAQVEEIRDPTLRSKALGIQQKNI-----VVTCNYVARAKGVTKLMLIAEAQRI 74
            |.:..:|||.|:.|||:.::|.||:|...:.|...     ::..:|.|||.|||:.|...:|:::
Human     7 RVVALVDMDCFFVQVEQRQNPHLRNKPCAVVQYKSWKGGGIIAVSYEARAFGVTRSMWADDAKKL 71

  Fly    75 CPDLVLVNGED------LAPYRQMSQRIFDLLLNYTPLVEKLGFDENFMDVTALVELR----QAH 129
            ||||:|....:      |..||:.|..:.:::..:. ::|:...||.::|:|:.|:.|    |..
Human    72 CPDLLLAQVRESRGKANLTKYREASVEVMEIMSRFA-VIERASIDEAYVDLTSAVQERLQKLQGQ 135

  Fly   130 VAEALLRP-------PVGHTYP-----------------ADGTPLSNCDCGCAQRLAIGTRIAQE 170
            ...|.|.|       |.|.|..                 .|...:.|......| |.:|..|.:|
Human   136 PISADLLPSTYIEGLPQGPTTAEETVQKEGMRKQGLFQWLDSLQIDNLTSPDLQ-LTVGAVIVEE 199

  Fly   171 IREELKLRLGITCCAGIAYNKLLAKLVGSSHEPNQQTVLVSTYAEQFMRELGDLKRVTGIGQKTQ 235
            :|..::...|..|.|||::||:||||....::||:||::......|...:: .::::..:|.|..
Human   200 MRAAIERETGFQCSAGISHNKVLAKLACGLNKPNRQTLVSHGSVPQLFSQM-PIRKIRSLGGKLG 263

  Fly   236 CLLLE-AGMSSVEQLQQCDMDVMRKKFGFETATRLRDLAFGRDTSLVRPSGKPKTIGMEDACK-- 297
            ..::| .|:..:.:|.|.....::..||.:..:.|..:..|.:...|:|...|||||    |.
Human   264 ASVIEILGIEYMGELTQFTESQLQSHFGEKNGSWLYAMCRGIEHDPVKPRQLPKTIG----CSKN 324

  Fly   298 -----PISVRTDVEERFRMLLKRLVEQVAED--------GRVPIAIKV-------------VLRK 336
                 .::.|..|:.....|.:.|.|::.:|        .::.::|:|             .|.:
Human   325 FPGKTALATREQVQWWLLQLAQELEERLTKDRNDNDRVATQLVVSIRVQGDKRLSSLRRCCALTR 389

  Fly   337 FDSQKKSSHRETKQANILPSLFKTSMCPGET--GVSKVQLADGAQDKLLKIVMRLFERIVDMSKP 399
            :|:.|.|....|...|...|..:|...|..|  .:...:.:..|......|...|      .|.|
Human   390 YDAHKMSHDAFTVIKNCNTSGIQTEWSPPLTMLFLCATKFSASAPSSSTDITSFL------SSDP 448

  Fly   400 FNITLLGLAFSKFQER---------KVGSSSIANFLIKKADLEVQSITSLTNTSLTSPT----AE 451
            .::..:.:..|:.:.:         |..::|:.:|..|.|  |.|.:...:.:|||:||    :.
Human   449 SSLPKVPVTSSEAKTQGSGPAVTATKKATTSLESFFQKAA--ERQKVKEASLSSLTAPTQAPMSN 511

  Fly   452 SPTSDECAFRSSPTTFKPSDQFYRRRATTASPVPMLLDNGSESAATNSDFSD 503
            ||:.....|::|.:|  .::.|:::::....  ...|:|.|.|:...:.:|:
Human   512 SPSKPSLPFQTSQST--GTEPFFKQKSLLLK--QKQLNNSSVSSPQQNPWSN 559

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DNApol-iota	NP_001287227.1	PolY_Pol_iota	18..411	CDD:176457	109/462 (24%)
POLH	NP_006493.1	DinP	7..>354	CDD:223466	92/353 (26%)
		PolY_Pol_eta	10..428	CDD:176456	104/424 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	441..472		4/36 (11%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	495..527		10/33 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	677..705
		PIP-box. /evidence=ECO:0000269|PubMed:15149598, ECO:0000269|PubMed:16357261	701..708

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0389
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1593931at2759
OrthoFinder	1	1.000	-	-		FOG0001835
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4551
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.850