DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DNApol-iota and DNApol-eta

DIOPT Version :9

Sequence 1:	NP_001287227.1	Gene:	DNApol-iota / 40965	FlyBaseID:	FBgn0037554	Length:	737	Species:	Drosophila melanogaster
Sequence 2:	NP_649371.2	Gene:	DNApol-eta / 40438	FlyBaseID:	FBgn0037141	Length:	885	Species:	Drosophila melanogaster

Alignment Length:	853	Identity:	193/853 - (22%)
Similarity:	319/853 - (37%)	Gaps:	227/853 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 HQRTIIHLDMDYFYAQVEEIRDPTLRSKALGIQQKNI-----VVTCNYVARAKGVTKLMLIAEAQ 72
            :.|.::.:|||.|:.||||.:.|..|::.|.:.|.|.     ::..||.|||||||:.|...||:
  Fly    14 YDRVVLLVDMDCFFCQVEEKQHPEYRNRPLAVVQYNPWRGGGIIAVNYAARAKGVTRHMRGDEAK 78

  Fly    73 RICPDLVLV------NGEDLAPYRQMSQRIFDLLLNYTPLVEKLGFDENFMDVTALV--ELRQAH 129
            .:||::||.      ...|.:.||...:.:.::|..:|.|:|:...||.::|:|..|  .::|..
  Fly    79 DLCPEIVLCQVPNIREKADTSKYRDAGKEVANVLQRFTQLLERASVDEAYLDITETVNHRMQQMQ 143

  Fly   130 VAEALLRP-------PVGHTYPADGTPLSNCDCGCAQ-------------------------RLA 162
            .....|:|       .||  ||:.|..::......|.                         ||.
  Fly   144 SGAFALQPQELVNTFAVG--YPSIGDYVNKITNRFANPYMDDERYQMSYDQNDLPAVRQSDIRLL 206

  Fly   163 IGTRIAQEIREELKLRLGITCCAGIAYNKLLAKLVGSSHEPNQQTVLVSTYAEQFMRELGDLKRV 227
            ||..:|.|:|..:|...|..|.||||:||:||||....::||:||:|..|........| .:.::
  Fly   207 IGASVAGEVRAAVKKETGYECSAGIAHNKILAKLAAGMNKPNKQTILPLTETASLFDSL-PVGKI 270

  Fly   228 TGIGQKTQCLLLEA----GMSSVEQLQQCDMDVMRKKFGFETATRLRDLAFGRDTSLVRPSGKPK 288
            .|:|.|...::.|.    .|..|.:..:.|   :::||..:..|.|.:::.|.|...|.|....|
  Fly   271 KGLGGKFGEVVCETLGIKFMGQVVKFSEVD---LQRKFDEKNGTWLFNISRGIDLEAVTPRFYSK 332

  Fly   289 TIGMEDACKPISVRTDVE----------ERFRMLLKRLVEQVAEDG-RVPIAIKVVLRKFDSQKK 342
            :||   .||....|.::.          |....:..||.:...|:. |....:...::..|.::.
  Fly   333 SIG---CCKKFPGRNNITGLKTLQHWLGELSSEINDRLEKDFIENNRRAKHMVVQYVQDIDGEEV 394

  Fly   343 SSHRETK------------QANILPSLFKTSMCPGE------------TGVSKVQLADGAQDKLL 383
            :|.|.|.            ..:::.:..||.:.||.            ..|.|.:.....|:||
  Fly   395 ASSRSTALRDYDQESIVRLSLDLIKANTKTFLRPGSESALNNAIKFLGISVGKFETVSSGQNKL- 458

  Fly   384 KIVMRLF------ERIVDMSKPFNITLLGLAFSKFQ--ERKVGSSSIANFL--IKKADLEVQSIT 438
               ..:|      :|.|...:|..:..:.:...:.|  |.|: .|..||:|  .||.|.:...|:
  Fly   459 ---QEMFANQAAKKRRVSGDEPGQLPKVEMEKKQKQTDEFKM-KSFFANYLQGAKKEDAKADGIS 519

  Fly   439 SLTNTSLTSPTAESPTSD---------ECAFR-------SSPTTFKPS--DQFYRRRATTASPVP 485
            :    :..:..|.:|..:         ..|.|       |:|..||.|  .|:.:::..|
  Fly   520 A----NPLAAAAGAPNKNFVEEYKHKLHAAVRTEGTVLTSTPAEFKESFFSQYLKQQKKT----- 575

  Fly   486 MLLDNGSESAATN-SDFSDFSETEVEPSPKKSRIGRLLVSKRSRLAADVGDSAAEVASPSKLRVC 549
                 |.:.:.|: .|..|..|               |..:...:.||
  Fly   576 -----GQQGSVTSREDSLDVQE---------------LAEELDAIEAD----------------- 603

  Fly   550 DLRLNSRDSEKDFPMSTTPSTSTSAPAPRFRT-----VQPPNTLLQRIDGSLRFVT-----TRTA 604
                ||:|.|:|....|..::.|....|..::     .|.||||.......|...|     |.|.
  Fly   604 ----NSKDFEEDTEEETELTSDTHMSKPEGQSSDAGQEQDPNTLNDSTGNDLYVETGIVPPTLTE 664

  Fly   605 SRLSSNASSTASSPLPSPMDD----SIAMSAPSTTTLPFPSPTTTAVVTSSSSTATCDALTNIVC 665
            ..|..:.|......:.|.:.:    .:..:.|:..|...|             |..||.     |
  Fly   665 DELKPSTSKRKFDEIESSVSNYKECYVEFAVPNLRTDILP-------------TIKCDQ-----C 711

  Fly   666 PAGVDAEVFKELPVELQT--------ELIASWRSSLVAAVEQTNGTGAATSAAIASGAPATATTA 722
            .|.:..||     ..|||        ||..:.||:     |:...|.:....::....|..:...
  Fly   712 GANIPDEV-----KSLQTHRDHHFAQELSRTLRST-----EREERTQSRQKISLKPTPPKKSKKT 766

  Fly   723 SGQKNTLY 730
            :|..::.|
  Fly   767 AGSGSSSY 774

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DNApol-iota	NP_001287227.1	PolY_Pol_iota	18..411	CDD:176457	120/482 (25%)
DNApol-eta	NP_649371.2	PolY_Pol_eta	20..447	CDD:176456	112/435 (26%)
		zf_UBZ	705..736	CDD:408236	12/40 (30%)
		zf_UBZ	805..832	CDD:408236
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45452756
Domainoid	1	1.000	61	1.000	Domainoid score	I2519
eggNOG	1	0.900	-	-		E1_COG0389
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1593931at2759
OrthoFinder	1	1.000	-	-		FOG0001835
OrthoInspector	1	1.000	-	-		otm46657
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4551
SonicParanoid	0	0.000	Not matched by this tool.
	8	7.780