DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DNApol-iota and Polh

DIOPT Version :9

Sequence 1:	NP_001287227.1	Gene:	DNApol-iota / 40965	FlyBaseID:	FBgn0037554	Length:	737	Species:	Drosophila melanogaster
Sequence 2:	NP_001101674.1	Gene:	Polh / 316235	RGDID:	1309893	Length:	689	Species:	Rattus norvegicus

Alignment Length:	621	Identity:	153/621 - (24%)
Similarity:	255/621 - (41%)	Gaps:	131/621 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 LDMDYFYAQVEEIRDPTLRSKALGIQQKNI-----VVTCNYVARAKGVTKLMLIAEAQRICPDLV 79
            :|||.|:.|||:.::|.||:|...:.|...     ::..:|.|||.|||:.|...:|:::||||:
  Rat    12 VDMDCFFVQVEQRQNPHLRNKPCAVVQYKSWKGGGIIAVSYEARAFGVTRNMWADDAKKLCPDLL 76

  Fly    80 LVNGED------LAPYRQMSQRIFDLLLNYTPLVEKLGFDENFMDVTALVELR----QAHVAEAL 134
            |....:      |..||:.|..:.:::.::. ::|:...||.::|:|..|:.|    |.....|.
  Rat    77 LAQVRESRGKANLTKYREASVEVMEIMSHFA-VIERASIDEAYIDLTNAVQERLEKLQGQPVSAD 140

  Fly   135 LRPPVGHTY-------PADGTPLSNCDC---GCAQ---------------RLAIGTRIAQEIREE 174
            |.|   .||       ||....:...|.   |..|               ||.:|..|.:|:|..
  Rat   141 LLP---STYIEGLPRGPAVEDTVEKEDIRKQGLLQWLGSLEKDDPTSPDLRLTVGAVIVEEMRAA 202

  Fly   175 LKLRLGITCCAGIAYNKLLAKLVGSSHEPNQQTVLVSTYAEQFMRELGDLKRVTGIGQKTQCLLL 239
            ::.:.|..|.|||::||:||||....::||:||::......|...:: .::::..:|.|....::
  Rat   203 IERKTGFQCSAGISHNKVLAKLACGLNKPNRQTLVSHGSVPQLFSQM-PIRKIRSLGGKLGASVI 266

  Fly   240 EA-GMSSVEQLQQCDMDVMRKKFGFETATRLRDLAFGRDTSLVRPSGKPKTIGMEDACK------ 297
            :. |:..:..|.|.....::..||.:..:.|..:..|.:...|:|...|||||    |.
  Rat   267 DVLGVEYMGDLTQFTEAQLQSHFGEKNGSWLYAMCRGIEHEPVKPRQLPKTIG----CSKNFPGK 327

  Fly   298 -PISVRTDVEERFRMLLKRLVEQVAED----GRVPIAIKVVLRKFDSQKKSS------------H 345
             .::.|..|:.....|...|.|::.:|    |||...:.|.:|....::.||            |
  Rat   328 TALATREQVQWWLLQLALELEERLTKDRTDNGRVATQLVVSIRVEGDKRLSSLRRCCALTRYDAH 392

  Fly   346 RETKQANILPSLFKTSMCPGETGVSKVQLADGAQDKLLKIVMRLFERIVDMSKPFNITLLGLAFS 410
            :.::.|      |.|......:||.                       .:.|.|  :|:|.|..:
  Rat   393 KMSQDA------FATIRNCNTSGVQ-----------------------TEWSPP--LTMLFLCAT 426

  Fly   411 KFQ-ERKVGSSSIANFLIKKADLEVQSITSLTNTSLTSPTAESPTSDECAFRSSPTTFKPSDQFY 474
            ||. ......:.|..||...:..:.:...:.:.|....|...:|||.|.| .|..:.|:.:.:..
  Rat   427 KFSASAPPACTDITVFLSSDSGCQPKVPAASSGTRTQEPGPAAPTSKEAA-TSLESFFQKAAKRQ 490

  Fly   475 RRRATT----------ASPVPMLLDNGSESAATNSDFSDFS----ETEVE----PSPKKSRIGRL 521
            |.|.|:          :|..|.||...|.|..|.|.|...|    .||:.    |.|.::.
  Rat   491 RMRETSFVPPKVAVEKSSSKPSLLFQTSGSPGTKSFFKQKSLLLQHTELSNAAAPCPPQAS---- 551

  Fly   522 LVSKRSRLAADVGDSAA---EVASPSKLRVCDLRLN 554
            ...:.|||..|..||.|   ||..|...:.....:|
  Rat   552 SAVQPSRLPTDRADSRASCEEVCKPVSSKAVSTEVN 587

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DNApol-iota	NP_001287227.1	PolY_Pol_iota	18..411	CDD:176457	111/454 (24%)
Polh	NP_001101674.1	DinP	8..>325	CDD:223466	87/321 (27%)
Polh	NP_001101674.1	PolY_Pol_eta	10..427	CDD:176456	111/454 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0389
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1593931at2759
OrthoFinder	1	1.000	-	-		FOG0001835
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820