Protein Alignment PolI and Polh

DIOPT Version :10

• Sequence 1: NP_649772.1
• Gene: PolI / 40965
• FlyBaseID: FBgn0037554
• Length: 737
• Species: Drosophila melanogaster
• Sequence 2: NP_001101674.1
• Gene: Polh / 316235
• RGDID: 1309893
• Length: 689
• Species: Rattus norvegicus
• Alignment Length: 621
• Identity: 153/621 - (24%)
• Similarity: 255/621 - (41%)
• Gaps: 131/621 - (21%)

  Fly    20 LDMDYFYAQVEEIRDPTLRSKALGIQQKNI-----VVTCNYVARAKGVTKLMLIAEAQRICPDLV 79
            :|||.|:.|||:.::|.||:|...:.|...     ::..:|.|||.|||:.|...:|:::||||:
  Rat    12 VDMDCFFVQVEQRQNPHLRNKPCAVVQYKSWKGGGIIAVSYEARAFGVTRNMWADDAKKLCPDLL 76

  Fly    80 LVNGED------LAPYRQMSQRIFDLLLNYTPLVEKLGFDENFMDVTALVELR----QAHVAEAL 134
            |....:      |..||:.|..:.:::.::. ::|:...||.::|:|..|:.|    |.....|.
  Rat    77 LAQVRESRGKANLTKYREASVEVMEIMSHFA-VIERASIDEAYIDLTNAVQERLEKLQGQPVSAD 140

  Fly   135 LRPPVGHTY-------PADGTPLSNCDC---GCAQ---------------RLAIGTRIAQEIREE 174
            |.|   .||       ||....:...|.   |..|               ||.:|..|.:|:|..
  Rat   141 LLP---STYIEGLPRGPAVEDTVEKEDIRKQGLLQWLGSLEKDDPTSPDLRLTVGAVIVEEMRAA 202

  Fly   175 LKLRLGITCCAGIAYNKLLAKLVGSSHEPNQQTVLVSTYAEQFMRELGDLKRVTGIGQKTQCLLL 239
            ::.:.|..|.|||::||:||||....::||:||::......|...:: .::::..:|.|....::
  Rat   203 IERKTGFQCSAGISHNKVLAKLACGLNKPNRQTLVSHGSVPQLFSQM-PIRKIRSLGGKLGASVI 266

  Fly   240 EA-GMSSVEQLQQCDMDVMRKKFGFETATRLRDLAFGRDTSLVRPSGKPKTIGMEDACK------ 297
            :. |:..:..|.|.....::..||.:..:.|..:..|.:...|:|...|||||    |.
  Rat   267 DVLGVEYMGDLTQFTEAQLQSHFGEKNGSWLYAMCRGIEHEPVKPRQLPKTIG----CSKNFPGK 327

  Fly   298 -PISVRTDVEERFRMLLKRLVEQVAED----GRVPIAIKVVLRKFDSQKKSS------------H 345
             .::.|..|:.....|...|.|::.:|    |||...:.|.:|....::.||            |
  Rat   328 TALATREQVQWWLLQLALELEERLTKDRTDNGRVATQLVVSIRVEGDKRLSSLRRCCALTRYDAH 392

  Fly   346 RETKQANILPSLFKTSMCPGETGVSKVQLADGAQDKLLKIVMRLFERIVDMSKPFNITLLGLAFS 410
            :.::.|      |.|......:||.                       .:.|.|  :|:|.|..:
  Rat   393 KMSQDA------FATIRNCNTSGVQ-----------------------TEWSPP--LTMLFLCAT 426

  Fly   411 KFQ-ERKVGSSSIANFLIKKADLEVQSITSLTNTSLTSPTAESPTSDECAFRSSPTTFKPSDQFY 474
            ||. ......:.|..||...:..:.:...:.:.|....|...:|||.|.| .|..:.|:.:.:..
  Rat   427 KFSASAPPACTDITVFLSSDSGCQPKVPAASSGTRTQEPGPAAPTSKEAA-TSLESFFQKAAKRQ 490

  Fly   475 RRRATT----------ASPVPMLLDNGSESAATNSDFSDFS----ETEVE----PSPKKSRIGRL 521
            |.|.|:          :|..|.||...|.|..|.|.|...|    .||:.    |.|.::.
  Rat   491 RMRETSFVPPKVAVEKSSSKPSLLFQTSGSPGTKSFFKQKSLLLQHTELSNAAAPCPPQAS---- 551

  Fly   522 LVSKRSRLAADVGDSAA---EVASPSKLRVCDLRLN 554
            ...:.|||..|..||.|   ||..|...:.....:|
  Rat   552 SAVQPSRLPTDRADSRASCEEVCKPVSSKAVSTEVN 587

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PolI	NP_649772.1	PolY_Pol_iota	18..411	CDD:176457	111/454 (24%)
Polh	NP_001101674.1	PolY_Pol_eta	10..427	CDD:176456	111/454 (24%)
		zf_UBZ	608..638	CDD:465769