DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DNApol-iota and Poli

DIOPT Version :9

Sequence 1:	NP_001287227.1	Gene:	DNApol-iota / 40965	FlyBaseID:	FBgn0037554	Length:	737	Species:	Drosophila melanogaster
Sequence 2:	NP_001099607.1	Gene:	Poli / 291526	RGDID:	1305212	Length:	732	Species:	Rattus norvegicus

Alignment Length:	754	Identity:	241/754 - (31%)
Similarity:	357/754 - (47%)	Gaps:	152/754 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 AHQRTIIHLDMDYFYAQVEEIRDPTLRSKALGIQQKNIVVTCNYVARAKGVTKLMLIAEAQRICP 76
            |..|.|:|:|:|.||||||.|.:|.|:.|.||:|||.:||||||.||..||.|||.:.:|:..||
  Rat    45 ASSRVIVHVDLDCFYAQVEMISNPELKDKPLGVQQKYLVVTCNYEARKLGVKKLMNVRDAKEKCP 109

  Fly    77 DLVLVNGEDLAPYRQMSQRIFDLLLNYTPLVEKLGFDENFMDVTALVE--LRQAHVAEALLRPPV 139
            .|||||||||:.||:||.::.:||..::|.||:|||||||:|:|.:||  |:|....|.   |.|
  Rat   110 QLVLVNGEDLSRYREMSYKVTELLEEFSPAVERLGFDENFVDLTEMVEKRLQQLPSDEV---PSV 171

  Fly   140 ---GHTYPADGTPLSNCDCGCAQRLAIGTRIAQEIREELKLRLGITCCAGIAYNKLLAKLVGSSH 201
               ||.|.....   |.......|||:|::||.|:||.:..:||:|.|||:|.||||||||....
  Rat   172 TMSGHVYNNQSV---NLHSSTHVRLAVGSQIAAEMREAMHNQLGLTGCAGVAPNKLLAKLVSGVF 233

  Fly   202 EPNQQTVLVSTYAEQFMRELGDLKRVTGIGQKTQCLLLEAGMSSVEQLQQCDMDVMRKKFGFETA 266
            :|||||||:....:..:..|..:|.:.|||.||...|...|::||..||...:..:.|:.|...|
  Rat   234 KPNQQTVLLPESCQHLIHSLNHIKEMPGIGYKTAKRLEVLGINSVHDLQTFPIKTLEKELGISVA 298

  Fly   267 TRLRDLAFGRDTSLVRPSGKPKTIGMEDACKPISVRTDVEERFRMLLKRLVEQVAEDGRVPIAIK 331
            .|:|.|:||.|.|.|.|||.|::...||..|..|...:.:.:...||..|:.:|..|||.|..|:
  Rat   299 QRIRKLSFGEDKSPVTPSGPPQSFSEEDTFKKCSSEVEAKTKIEELLSSLLNRVCHDGRKPHTIR 363

  Fly   332 VVLRKFDSQKKSSHRETKQANILPSLFKTSMCPGETGVSKVQLADGAQD---KLLKIVMRLFERI 393
            :|:|::..  |..:||::|            ||..:.|.: :|..|..|   .|::|:|:||..:
  Rat   364 LVIRRYSD--KHCNRESRQ------------CPIPSHVIQ-KLGTGNYDAVPPLMEILMKLFRNM 413

  Fly   394 VDMSKPFNITLLGLAFSKFQERKVGSSSIANFLIKKADLEVQSITSLTNTSLTSPTA-------- 450
            |::...|::|||.:.|...   |..:|:      ||..::....:||:.|:.:...:
  Rat   414 VNVKMAFHLTLLSVCFCNL---KALNSA------KKGPMDCFLTSSLSTTACSGKRSFKVKDIHM 469

  Fly   451 -----ESPTSDEC----AFRSSPTTFKPSDQ--FYRRRATTASPVPMLLD--------------- 489
                 |...:.:|    ...|:.....|||.  |.:.:.|:..|:..|.:
  Rat   470 EDSYKEKEANWDCLPSRRIESTRRGESPSDATCFPKEKDTSDLPLQFLPEGVDQEVFTQLPADIQ 534

  Fly   490 --------------NGSESA---ATNSDFSDFSETEVEP---SPKKSRIGRLLVSKRSRLAA--D 532
                          .||.|.   |:....|.||..:.:.   ||:.:    ||..|::...:  :
  Rat   535 EEILSGKSRENLQGKGSLSCPLHASRGVLSFFSTKQTQAGCLSPRDT----LLTGKQASAVSPCE 595

  Fly   533 VGDSAAEVAS---PSKLRVCDLRLNSRDSEKDFPMSTTPSTSTSAPAPRFRTVQP--------PN 586
            .|.|....:|   ||..:.|...::::  .||..||..|   |.:....|....|        ||
  Rat   596 PGTSGLSTSSSSHPSCGKDCSYYVDNQ--LKDERMSQGP---TESQGFHFSNTNPAVSVFHSFPN 655

  Fly   587 TLLQRIDGSLRFVTTRTASRLSSNASSTASSPLPSPMDDSIAMSAPSTTTLPFPSPTTTAVVTSS 651
            ...:::     |.|.|||......| :|:...|.:...||      :...|.|||
  Rat   656 LQSEQL-----FSTHRTADSHKQTA-TTSHQGLENREQDS------ADEKLTFPS---------- 698

  Fly   652 SSTATCDALTNIVCPAGVDAEVFKELPVELQTELIASWR 690
                            .:|.:||.|||.|:|.||:|.|:
  Rat   699 ----------------DIDPQVFYELPEEVQRELMAEWK 721

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DNApol-iota	NP_001287227.1	PolY_Pol_iota	18..411	CDD:176457	167/400 (42%)
Poli	NP_001099607.1	DinP	48..384	CDD:223466	154/355 (43%)
Poli	NP_001099607.1	PolY_Pol_iota	51..431	CDD:176457	167/400 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353309
Domainoid	1	1.000	170	1.000	Domainoid score	I3696
eggNOG	1	0.900	-	-		E1_COG0389
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	320	1.000	Inparanoid score	I2441
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1593931at2759
OrthoFinder	1	1.000	-	-		FOG0001835
OrthoInspector	1	1.000	-	-		oto96260
orthoMCL	1	0.900	-	-		OOG6_106220
Panther	1	1.100	-	-	LDO	PTHR46404
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X5102
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.760