DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DNApol-iota and Poli

DIOPT Version :9

Sequence 1:	NP_001287227.1	Gene:	DNApol-iota / 40965	FlyBaseID:	FBgn0037554	Length:	737	Species:	Drosophila melanogaster
Sequence 2:	NP_036102.2	Gene:	Poli / 26447	MGIID:	1347081	Length:	737	Species:	Mus musculus

Alignment Length:	787	Identity:	245/787 - (31%)
Similarity:	365/787 - (46%)	Gaps:	157/787 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 ASVLGKSEA-----------HQRTIIHLDMDYFYAQVEEIRDPTLRSKALGIQQKNIVVTCNYVA 57
            |...|.|.|           ..|.|:|:|:|.||||||.|.:|.|:.:.||:|||.:||||||.|
Mouse    26 AGAAGSSRAVCSQGPPTQISSSRVIVHVDLDCFYAQVEMISNPELKDRPLGVQQKYLVVTCNYEA 90

  Fly    58 RAKGVTKLMLIAEAQRICPDLVLVNGEDLAPYRQMSQRIFDLLLNYTPLVEKLGFDENFMDVTAL 122
            |..||.|||.:.:|:..||.|||||||||:.||:||.::.:||..::|.||:|||||||:|:|.:
Mouse    91 RKLGVRKLMNVRDAKEKCPQLVLVNGEDLSRYREMSYKVTELLEEFSPAVERLGFDENFVDLTEM 155

  Fly   123 VE--LRQAHVAEALLRPPVGHTYPADGTPLSNCDCGCAQRLAIGTRIAQEIREELKLRLGITCCA 185
            ||  |:|....|.......||.|......|.|.   ..:||.:|::||.|:||.:..:||:|.||
Mouse   156 VEKRLQQLPSEEVPSVTVFGHVYNNQSVNLHNI---MHRRLVVGSQIAAEMREAMYNQLGLTGCA 217

  Fly   186 GIAYNKLLAKLVGSSHEPNQQTVLVSTYAEQFMRELGDLKRVTGIGQKTQCLLLEAGMSSVEQLQ 250
            |:|.||||||||....:|||||||:....:..:..|..:|.:.|||.||...|...|::||..||
Mouse   218 GVAPNKLLAKLVSGVFKPNQQTVLLPESCQHLIHSLNHIKEIPGIGYKTAKRLEVLGINSVHDLQ 282

  Fly   251 QCDMDVMRKKFGFETATRLRDLAFGRDTSLVRPSGKPKTIGMEDACKPISVRTDVEERFRMLLKR 315
            ...:..:.|:.|...|.|::.|:||.|.|.|.|||.|::...||..|..|...:.:.:...||..
Mouse   283 TFPIKTLEKELGIAIAQRIQQLSFGEDKSPVTPSGPPQSFSEEDTFKKCSSEVEAKAKIEELLSS 347

  Fly   316 LVEQVAEDGRVPIAIKVVLRKFDSQKKSSHRETKQANILPSLFKTSMCPGETGVSKVQLADGAQD 380
            |:.:|.:|||.|..:::|:|::..  |..:||::|            ||..:.|.: :|..|..|
Mouse   348 LLTRVCQDGRKPHTVRLVIRRYSD--KHCNRESRQ------------CPIPSHVIQ-KLGTGNHD 397

  Fly   381 K---LLKIVMRLFERIVDMSKPFNITLLGLAFSKFQERKVGSSSIANFLIKKADLEVQSITSLTN 442
            .   |:.|:|:||..:|::..||::||:.:.|...   |..||:      ||..::.. :|||:.
Mouse   398 SMPPLIDILMKLFRNMVNVKMPFHLTLMSVCFCNL---KALSSA------KKGPMDCY-LTSLST 452

  Fly   443 TSLTSPTA----ESPTSD---------EC----AFRSSPTTFKPSDQ--FYRRRATTASPVPMLL 488
            .:.|...|    ::.|.|         :|    ...|:.|...|.|.  |.:.:.|:..|:..|.
Mouse   453 PAYTDKRAFKVKDTHTEDSHKEKEANWDCLPSRRIESTGTGESPLDATCFPKEKDTSDLPLQALP 517

  Fly   489 D-----------------------------NGSESA---ATNSDFSDFSETEVEPSPKKSRIGRL 521
            :                             .||.|.   |:....|.||..:::.|....| ...
Mouse   518 EGVDQEVFKQLPADIQEEILSGKSRENLKGKGSLSCPLHASRGVLSFFSTKQMQASRLSPR-DTA 581

  Fly   522 LVSKRSRLAADV-----GDSAAEVASPSKLRVCDLRLNSRDSEKDFPMSTTPSTSTSAPAPRFRT 581
            |.|||...|:..     |.|....:.||..:.|...::|:  .||...|..|:.|...   :|.:
Mouse   582 LPSKRVSAASPCEPGTSGLSPGSTSHPSCGKDCSYYIDSQ--LKDEQTSQGPTESQGC---QFSS 641

  Fly   582 VQP--------PNTLLQRIDGSLRFVTTRTASRLSSNASSTASSPLPSPMDDSIAMSAPSTTTLP 638
            ..|        ||...:::..:.|.|.:...:..:|:....:...|.|...||      :...||
Mouse   642 TNPAVSGFHSFPNLQTEQLFSTHRTVDSHKQTATASHQGLESHQGLESRELDS------AEEKLP 700

  Fly   639 FPSPTTTAVVTSSSSTATCDALTNIVCPAGVDAEVFKELPVELQTELIASWRSSLVAAVEQTNGT 703
            |                          |..:|.:||.|||.|:|.||:|.|..:
Mouse   701 F--------------------------PPDIDPQVFYELPEEVQKELMAEWERA----------- 728

  Fly   704 GAATSAA 710
            |||..:|
Mouse   729 GAARPSA 735

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DNApol-iota	NP_001287227.1	PolY_Pol_iota	18..411	CDD:176457	162/397 (41%)
Poli	NP_036102.2	PolY_Pol_iota	51..431	CDD:176457	162/397 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849657
Domainoid	1	1.000	170	1.000	Domainoid score	I3779
eggNOG	1	0.900	-	-		E1_COG0389
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	293	1.000	Inparanoid score	I2748
Isobase	1	0.950	-	0	Normalized mean entropy	S5319
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1593931at2759
OrthoFinder	1	1.000	-	-		FOG0001835
OrthoInspector	1	1.000	-	-		oto92696
orthoMCL	1	0.900	-	-		OOG6_106220
Panther	1	1.100	-	-	LDO	PTHR46404
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4551
SonicParanoid	1	1.000	-	-		X5102
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.740