DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DNApol-iota and eso1

DIOPT Version :9

Sequence 1:	NP_001287227.1	Gene:	DNApol-iota / 40965	FlyBaseID:	FBgn0037554	Length:	737	Species:	Drosophila melanogaster
Sequence 2:	NP_596778.1	Gene:	eso1 / 2539666	PomBaseID:	SPBC16A3.11	Length:	872	Species:	Schizosaccharomyces pombe

Alignment Length:	758	Identity:	175/758 - (23%)
Similarity:	293/758 - (38%)	Gaps:	216/758 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDFASVLGKSEAHQRTIIHLDMDYFYAQVEEIRDPTLRSKALGIQQKNIVVTCNYVARAKGVTKL 65
            :.:....|...:..|.:.|:|.|.||||||.:|.....|..|.:||...::..||.|||..:::.
pombe    13 LQYCDKAGTQNSPLRVVAHIDQDAFYAQVESVRLGLDHSVPLAVQQWQGLIAVNYAARAANISRH 77

  Fly    66 MLIAEAQRICPDLVLVN------GED----------------LAPYRQMSQRIFDLLLNYTPLVE 108
            ..:.||::.||:|...:      ||.                |.|||..|.:|.:::..:.|:|:
pombe    78 ETVTEAKKKCPELCTAHVKTWKAGESEAKYHENPNPNYYKTCLDPYRHESVKILNIIKKHAPVVK 142

  Fly   109 KLGFDENFMDVTALVE--------------------LRQAHVAEALLRPP----------VGHT- 142
            |...||.|:::|:.|:                    |.||.|   ||.|.          |..|
pombe   143 KASIDECFIELTSDVKRIVLEEYPYLKIPSEDSNVALPQAPV---LLWPAEFGMVIEEEVVDRTK 204

  Fly   143 --YPADGTPLSNCDCGCAQRLAIGTRIAQEIREELKLRLGITCCAGIAYNKLLAKLVGSSHEPNQ 205
              |..|...:.         |....:|.:|||:::.|:|..||.||:::|.:|:|||.|.::||:
pombe   205 EDYERDWDDVF---------LFYAAKIVKEIRDDIYLQLKYTCSAGVSFNPMLSKLVSSRNKPNK 260

  Fly   206 QTVLVSTYAEQFM--RELGDLKRVTG-IGQKTQCLLLEAGMSSVEQLQQCDMDVMRKKFGFETAT 267
            ||:|.....:.::  .::.|::.:.| .|::...||   |..|::.:....||.:..|.|.....
pombe   261 QTILTKNAIQDYLVSLKITDIRMLGGKFGEEIINLL---GTDSIKDVWNMSMDFLIDKLGQTNGP 322

  Fly   268 RLRDLAFGRDTSLV------------RPSGKPKTIGMEDACKPISV-RTDVEERFRMLLKRLVEQ 319
            .:.:|..|.|.:.:            :...:.|....|||.....| .:|:..||..|
pombe   323 LVWNLCHGIDNTEITTQVQIKSMLSAKNFSQQKVKSEEDAINWFQVFASDLRSRFLEL------- 380

  Fly   320 VAEDGRVP--IAIKVVLRKFDSQKKSSHRETKQANILPSLFKTSMCPGETGVSKVQLADGAQDKL 382
              |..|.|  |.:.||.|..   :||               ::|..|....:| .|....|..||
pombe   381 --EGMRRPKTICLTVVSRFL---RKS---------------RSSQIPMNVDIS-TQFIVEATSKL 424

  Fly   383 LKIVMRLFERIVDMSKPFNITLLGLAFSKFQERKVGSSSIANFLIKKADLEVQSITSLTNTSLTS 447
            |:.:.:.|:       .:.|:.|.::|....|....|..|..|| ||::.|:...||:      |
pombe   425 LRQLQQEFD-------VYPISNLSISFQNIIEVDRNSRGIEGFL-KKSNDEIYMSTSV------S 475

  Fly   448 PTAESPTSDECAFRSSPTTFKPSDQFYRRRATTASPVPMLLDNGSESAATNSDFSDFSETEVEPS 512
            |:.|.                        ||       .||   :|:...|:.|...||.::: |
pombe   476 PSIEG------------------------RA-------KLL---NENMRENNSFELSSEKDIK-S 505

  Fly   513 PKKSRIGR----------LLVSKRSRLAADVGDSAAEVASPSKLRVCD--LRLNSRDSEKDFPMS 565
            ||:.:.|:          ..|||.:..:||...:..|         |:  :.|:.|:..:|:.::
pombe   506 PKRLKRGKGKGIFDMLQQTAVSKPTENSADETYTCEE---------CEQKITLSERNEHEDYHIA 561

  Fly   566 TTPSTSTSAPAPRFRTVQPPNTLLQRIDGSLRFVTTRTASRLSSNASSTASSPLPSPMDDSIA-- 628
            .:.|..     .|:..:.||:      ....:.|..:|..|   ...|...:||....::..|
pombe   562 LSISRK-----ERYNNLVPPS------HDKPKQVKPKTYGR---KTGSKHYAPLSDETNNKRAFL 612

  Fly   629 ---MSAPSTTTLPFPSPTTTAVVTSS-----------SSTATC 657
               :......|..:...|..|:..||           :||.||
pombe   613 DAFLGNGGNLTPNWKKQTPKAISNSSDNMTQLHLDLANSTVTC 655

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DNApol-iota	NP_001287227.1	PolY_Pol_iota	18..411	CDD:176457	117/465 (25%)
eso1	NP_596778.1	DinP	27..467	CDD:223466	125/490 (26%)
		PolY_Pol_eta	30..446	CDD:176456	117/465 (25%)
		zf-C2H2_3	643..679	CDD:290589	4/13 (31%)
		Acetyltransf_13	797..853	CDD:290591
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0389
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001835
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4551
SonicParanoid	1	1.000	-	-		X5102
TreeFam	1	0.960	-	-
	6	5.800