Protein Alignment DNApol-iota and ESCO2

DIOPT Version :9

• Sequence 1: NP_001287227.1
• Gene: DNApol-iota / 40965
• FlyBaseID: FBgn0037554
• Length: 737
• Species: Drosophila melanogaster
• Sequence 2: NP_001017420.1
• Gene: ESCO2 / 157570
• HGNCID: 27230
• Length: 601
• Species: Homo sapiens
• Alignment Length: 504
• Identity: 94/504 - (18%)
• Similarity: 173/504 - (34%)
• Gaps: 169/504 - (33%)

  Fly   103 YTPLVEKLGFDENFMDVTALVELRQAHVAEALLRPPVGHTYPADGTPLSNCDCGCAQRLAIGTRI 167
            |.|:|||    ||           ..|.||                  :|.:   |.|:     :
Human   172 YKPIVEK----EN-----------NCHSAE------------------NNSN---APRV-----L 195

  Fly   168 AQEIREELKLRLGITCCAGIAYNKLLAKLVGSSHEP-------NQQTVL----VSTYAEQFMREL 221
            :|:|:.::.|:.|   .|.....|...:.....:||       ::..|:    |.|.:|
Human   196 SQKIKPQVTLQGG---AAFFVRKKSSLRKSSLENEPSLGRTQKSKSEVIEDSDVETVSE------ 251

  Fly   222 GDLKRVTGIGQKTQCLLLE---------AGMSSVEQL--QQCDMDVMRKKFGFETATRLRDLAFG 275
               |:.....|..:||:||         |...:.|:|  ...|..|..|:...:     ::.||.
Human   252 ---KKTFATRQVPKCLVLEEKLKIGLLSASSKNKEKLIKDSSDDRVSSKEHKVD-----KNEAFS 308

  Fly   276 RDTSLVRPSGKPKTIGMEDACKPISVRTDVEERFRMLLKRLVEQVAEDGRVPIAIKVVLRKFDSQ 340
            .:.||    |:.|||..:....||...:.|..:     :.|.|:....|.|....:..::| ::.
Human   309 SEDSL----GENKTISPKSTVYPIFSASSVNSK-----RSLGEEQFSVGSVNFMKQTNIQK-NTN 363

  Fly   341 KKSSHRETKQANILPS---LFKTSMCPGETGVSKVQLADGAQDKL------------LKIVMRLF 390
            .:.:.::||...|:.:   .|..::|   .....:..|...:|::            :|.|....
Human   364 TRDTSKKTKDQLIIDAGQKHFGATVC---KSCGMIYTASNPEDEMQHVQHHHRFLEGIKYVGWKK 425

  Fly   391 ERIVDMSKPFNITLL-----GLAFSKFQ------ERKVGSSSIANFLIKKADLEVQSITSLTNTS 444
            ||:|.......|.|:     ..|..|.:      :.::|...:    :.|...::::...:::..
Human   426 ERVVAEFWDGKIVLVLPHDPSFAIKKVEDVQELVDNELGFQQV----VPKCPNKIKTFLFISDEK 486

  Fly   445 -----------------LTSPTA-ESPTSDECAFRSSPTTFKPSD---------------QFYRR 476
                             |:.|.. |||:|.||     |..::.||               :..||
Human   487 RVVGCLIAEPIKQAFRVLSEPIGPESPSSTEC-----PRAWQCSDVPEPAVCGISRIWVFRLKRR 546

  Fly   477 RATTASPVPMLLDNGSESAATNSDFSDFSETEVEPSPKKSRIGRLLVSK 525
            :......|..|.:........::|...||    :|:|.    |:|..:|
Human   547 KRIARRLVDTLRNCFMFGCFLSTDEIAFS----DPTPD----GKLFATK 587

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DNApol-iota	NP_001287227.1	PolY_Pol_iota	18..411	CDD:176457	68/349 (19%)
ESCO2	NP_001017420.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	222..243		3/20 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	282..315		9/41 (22%)
		zf-C2H2_3	374..413	CDD:290589	5/41 (12%)
		Acetyltransf_13	529..591	CDD:290591	12/67 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4551
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.030