DRSC/TRiP Functional Genomics Resources

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Protein Alignment DNApol-iota and ESCO1

DIOPT Version :9

Sequence 1:NP_001287227.1 Gene:DNApol-iota / 40965 FlyBaseID:FBgn0037554 Length:737 Species:Drosophila melanogaster
Sequence 2:NP_443143.2 Gene:ESCO1 / 114799 HGNCID:24645 Length:840 Species:Homo sapiens


Alignment Length:599 Identity:110/599 - (18%)
Similarity:201/599 - (33%) Gaps:176/599 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   174 ELKLRLGITCCAGIAYNKLLAKLVGSSHEPNQQTVLVSTYA---------------------EQF 217
            ||:.|:. |..:..|.|....|.:      |:.||.|..|:                     ||.
Human    61 ELETRMS-TRSSKAASNDKATKSI------NKNTVTVRGYSQESTKKKLSQKKLVHENPKANEQL 118

  Fly   218 MRELGDLKRVTGIGQKT-QCLLLEAGMSSVEQ------LQQC-----------DMDVMRKKFGFE 264
            .|....|:::|.:.::: :...::..:.:|:|      .:||           ...|.||....:
Human   119 NRRSQRLQQLTEVSRRSLRSREIQGQVQAVKQSLPPTKKEQCSSTQSKSNKTSQKHVKRKVLEVK 183

  Fly   265 TATRLRDLAFGRDTSLV------RPSGKPKTIGMEDACKPISVRTDVEERFRMLLKRL-----VE 318
            :.::       .|.:||      .|.||.:.:..:.||...|..|...|:......|.     |.
Human   184 SDSK-------EDENLVINEVINSPKGKKRKVEHQTACACSSQCTQGSEKCPQKTTRRDETKPVP 241

  Fly   319 QVAEDGRVPIAIKVVLRKFDSQKKSSHRETKQANILPSLFKTSMCPGETGVSKVQLADGAQDKLL 383
            ..:|..|..:|..||.:| :..|||.|.:......||.    |..|.....|..:|....:.|..
Human   242 VTSEVKRSKMATSVVPKK-NEMKKSVHTQVNTNTTLPK----SPQPSVPEQSDNELEQAGKSKRG 301

  Fly   384 KIVMRLFERIVDMSKPFNITLLGLAFSKFQERKVGSSSIANFLIKKADLEVQSITSLTNTSLTSP 448
            .| ::|.|.|                       .|.....|..:||...:::|:..         
Human   302 SI-LQLCEEI-----------------------AGEIESDNVEVKKESSQMESVKE--------- 333

  Fly   449 TAESPTS---DECAFRSSPTTFKPSDQ------FYRRRATTASPVPMLLDNGSESAATNSDFSDF 504
              |.||.   :|.:........|.::|      |:..|.|  .||..:|:..:.||..||:::..
Human   334 --EKPTEIKLEETSVERQILHQKETNQDVQCNRFFPSRKT--KPVKCILNGINSSAKKNSNWTKI 394

  Fly   505 SETEVEPSPKKSRIGRLLVSKRSRLAADVGDSAAEVASP--------SKLR----VCD----LRL 553
            ..::.. |.:.:::...:..|...|.......|.|:..|        :||.    .|.    ..:
Human   395 KLSKFN-SVQHNKLDSQVSPKLGLLRTSFSPPALEMHHPVTQSTFLGTKLHDRNITCQQEKMKEI 458

  Fly   554 NSRDSEKDFPMSTTPSTSTSAP-----APRFRTVQPPNTLLQRIDGSLRFVTTRTASRLSSNASS 613
            ||.:.:.:........|:..||     |...:...||      :|..::       ....|.::.
Human   459 NSEEVKINDITVEINKTTERAPENCHLANEIKPSDPP------LDNQMK-------HSFDSASNK 510

  Fly   614 TASSPLPSPMDDSIAMSAPSTTTL-------------PFPSPTTTAVVTSSSSTAT--------- 656
            ..|..|.|.:::|...:..:.:||             |..:|...:::::.:|.::         
Human   511 NFSQCLESKLENSPVENVTAASTLLSQAKIDTGENKFPGSAPQQHSILSNQTSKSSDNRETPRNH 575

  Fly   657 ----CDALTNIVCP 666
                |::...|..|
Human   576 SLPKCNSHLEITIP 589

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DNApol-iotaNP_001287227.1 PolY_Pol_iota 18..411 CDD:176457 58/286 (20%)
ESCO1NP_443143.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..188 24/140 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 221..300 20/83 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 318..338 6/30 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 486..505 4/31 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 542..582 4/39 (10%)
zf-C2H2_3 604..643 CDD:290589
Acetyltransf_13 763..825 CDD:290591
Acetyl-CoA binding. /evidence=ECO:0000269|PubMed:27112597, ECO:0000269|PubMed:27803161, ECO:0007744|PDB:4MXE, ECO:0007744|PDB:5T53 772..774
Acetyl-CoA binding. /evidence=ECO:0000269|PubMed:27112597, ECO:0000269|PubMed:27803161, ECO:0007744|PDB:4MXE, ECO:0007744|PDB:5T53 780..785
Acetyl-CoA binding. /evidence=ECO:0000269|PubMed:27112597, ECO:0000269|PubMed:27803161, ECO:0007744|PDB:4MXE, ECO:0007744|PDB:5T53 812..814
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4551
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
11.030

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