DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DNApol-iota and POLI

DIOPT Version :9

Sequence 1:	NP_001287227.1	Gene:	DNApol-iota / 40965	FlyBaseID:	FBgn0037554	Length:	737	Species:	Drosophila melanogaster
Sequence 2:	NP_009126.2	Gene:	POLI / 11201	HGNCID:	9182	Length:	740	Species:	Homo sapiens

Alignment Length:	757	Identity:	233/757 - (30%)
Similarity:	360/757 - (47%)	Gaps:	143/757 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 VLGKSEAHQRTIIHLDMDYFYAQVEEIRDPTLRSKALGIQQKNIVVTCNYVARAKGVTKLMLIAE 70
            ||....|..|.|:|:|:|.||||||.|.:|.|:.|.||:|||.:||||||.||..||.|||.:.:
Human    44 VLPTPNASSRVIVHVDLDCFYAQVEMISNPELKDKPLGVQQKYLVVTCNYEARKLGVKKLMNVRD 108

  Fly    71 AQRICPDLVLVNGEDLAPYRQMSQRIFDLLLNYTPLVEKLGFDENFMDVTALVE--LRQAHVAEA 133
            |:..||.|||||||||..||:||.::.:||..::|:||:|||||||:|:|.:||  |:|....|.
Human   109 AKEKCPQLVLVNGEDLTRYREMSYKVTELLEEFSPVVERLGFDENFVDLTEMVEKRLQQLQSDEL 173

  Fly   134 LLRPPVGHTYPADGTPLSNCDCGCAQRLAIGTRIAQEIREELKLRLGITCCAGIAYNKLLAKLVG 198
            ......||.|......|.:.   ...||.:|::||.|:||.:..:||:|.|||:|.||||||||.
Human   174 SAVTVSGHVYNNQSINLLDV---LHIRLLVGSQIAAEMREAMYNQLGLTGCAGVASNKLLAKLVS 235

  Fly   199 SSHEPNQQTVLVSTYAEQFMRELGDLKRVTGIGQKTQCLLLEAGMSSVEQLQQCDMDVMRKKFGF 263
            ...:|||||||:....:..:..|..:|.:.|||.||...|...|::||..||.....::.|:.|.
Human   236 GVFKPNQQTVLLPESCQHLIHSLNHIKEIPGIGYKTAKCLEALGINSVRDLQTFSPKILEKELGI 300

  Fly   264 ETATRLRDLAFGRDTSLVRPSGKPKTIGMEDACKPISVRTDVEERFRMLLKRLVEQVAEDGRVPI 328
            ..|.|::.|:||.|.|.|..||.|::...||:.|..|...:.:.:...||..|:.:|.:|||.|.
Human   301 SVAQRIQKLSFGEDNSPVILSGPPQSFSEEDSFKKCSSEVEAKNKIEELLASLLNRVCQDGRKPH 365

  Fly   329 AIKVVLRKFDSQKKSSHRETKQANILPSLFKTSMCPGETGVSKVQLADGAQD---KLLKIVMRLF 390
            .:::::|::.|:|... ||::|            ||..:.|.: :|..|..|   .::.|:|:||
Human   366 TVRLIIRRYSSEKHYG-RESRQ------------CPIPSHVIQ-KLGTGNYDVMTPMVDILMKLF 416

  Fly   391 ERIVDMSKPFNITLLGLAFSKFQERKVGSSSIANFLIKKADLEVQSITSLTNTSLTSPTAESPTS 455
            ..:|::..||::|||.:.|...:.....         ||..::...:.||:.||
Human   417 RNMVNVKMPFHLTLLSVCFCNLKALNTA---------KKGLIDYYLMPSLSTTS----------- 461

  Fly   456 DECAFRSSPTTFKPSD----QFYRRRATTASPVPMLLDNGSESAATNSDFSDFS-ETEVEPSPKK 515
                 ||...:||..|    .|.:.:.|....:|......:.:..:..|.::|| |.::...|..
Human   462 -----RSGKHSFKMKDTHMEDFPKDKETNRDFLPSGRIESTRTRESPLDTTNFSKEKDINEFPLC 521

  Fly   516 S---------------RIGRLLVSKRSR--------LAADVGDSAAEVASPSKLRVCDLRLNSRD 557
            |               .|...::|.:||        ::..:..|...::..||.::.|:.:|.||
Human   522 SLPEGVDQEVFKQLPVDIQEEILSGKSREKFQGKGSVSCPLHASRGVLSFFSKKQMQDIPINPRD 586

  Fly   558 SEKDFPMSTTPSTSTSAPAPRFRTVQPPNTLLQRIDGSLRFVTTRTASRLSSNASSTASSP---- 618
            .     :|::...|:.:|.       .|.|                 |..:|::||..||.
Human   587 H-----LSSSKQVSSVSPC-------EPGT-----------------SGFNSSSSSYMSSQKDYS 622

  Fly   619 --LPSPMDDSIAMSAPS-------TTTLP-------FPS---------PTTTAVVTSSSSTATCD 658
              |.:.:.|......|.       |.:.|       ||:         ..||.....:.:|.:.:
Human   623 YYLDNRLKDERISQGPKEPQGFHFTNSNPAVSAFHSFPNLQSEQLFSRNHTTDSHKQTVATDSHE 687

  Fly   659 ALT----------NIVCPAGVDAEVFKELPVELQTELIASWR 690
            .||          .|..|:.:|.:||.|||..:|.||:|.|:
Human   688 GLTENREPDSVDEKITFPSDIDPQVFYELPEAVQKELLAEWK 729

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DNApol-iota	NP_001287227.1	PolY_Pol_iota	18..411	CDD:176457	161/397 (41%)
POLI	NP_009126.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		DinP	53..390	CDD:223466	148/352 (42%)
		PolY_Pol_iota	56..437	CDD:176457	161/397 (41%)
		DNA binding. /evidence=ECO:0000269\|PubMed:15254543, ECO:0000269\|PubMed:27555320, ECO:0007744\|PDB:1T3N, ECO:0007744\|PDB:5KT2, ECO:0007744\|PDB:5KT4, ECO:0007744\|PDB:5KT6	249..314		20/64 (31%)
		DNA binding. /evidence=ECO:0000269\|PubMed:15254543, ECO:0000269\|PubMed:27555320, ECO:0007744\|PDB:1T3N, ECO:0007744\|PDB:5KT2, ECO:0007744\|PDB:5KT4, ECO:0007744\|PDB:5KT6	325..439		35/127 (28%)
		Ubiquitin-binding 1 (UBM1). /evidence=ECO:0000250\|UniProtKB:Q6R3M4	527..544		1/16 (6%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	581..615		12/62 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	671..704		6/32 (19%)
		Ubiquitin-binding 2 (UBM2). /evidence=ECO:0000250\|UniProtKB:Q6R3M4	708..725		8/16 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159288
Domainoid	1	1.000	168	1.000	Domainoid score	I3854
eggNOG	1	0.900	-	-		E1_COG0389
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	294	1.000	Inparanoid score	I2778
Isobase	1	0.950	-	0	Normalized mean entropy	S5319
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1593931at2759
OrthoFinder	1	1.000	-	-		FOG0001835
OrthoInspector	1	1.000	-	-		oto89129
orthoMCL	1	0.900	-	-		OOG6_106220
Panther	1	1.100	-	-	LDO	PTHR46404
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4551
SonicParanoid	1	1.000	-	-		X5102
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.740