Protein Alignment CG18249 and Igfals

DIOPT Version :10

• Sequence 1: NP_001163549.1
• Gene: CG18249 / 40964
• FlyBaseID: FBgn0037553
• Length: 559
• Species: Drosophila melanogaster
• Sequence 2: NP_445781.3
• Gene: Igfals / 79438
• RGDID: 68429
• Length: 603
• Species: Rattus norvegicus
• Alignment Length: 553
• Identity: 142/553 - (25%)
• Similarity: 205/553 - (37%)
• Gaps: 162/553 - (29%)

  Fly     6 YILLGICGLTVSDALAVYDASGRFNLSASCP--------------DSFCSL-------SDRPVA- 48
            ::.||.|.|..:|..|..||.|     ..||              ..|||.       .|.||:
  Rat    17 WVALGPCHLQGTDPGASADAEG-----PQCPVACTCSHDDYTDELSVFCSSKNLTHLPDDIPVST 76

  Fly    49 ---------YSATPALQLRELHLRNCSRQSITWLVLQ------LTPGLRTLVIRNCATYHISKES 98
                     .|:.|:...:.|       .|:.:|.||      |.| ...|.::|....|:.:..
  Rat    77 RALWLDGNNLSSIPSAAFQNL-------SSLDFLNLQGSWLRSLEP-QALLGLQNLYHLHLERNR 133

  Fly    99 LRPV--------ENLTSLQMQGTSLGVLRDQIFNAVPRLEILQLSQNFIHTVHVAAFQGLSKLRL 155
            ||.:        .:|.||.:....||.|.:.:|..:..|..|.|..|.:..:....||||..|..
  Rat   134 LRNLAVGLFTHTPSLASLSLSSNLLGRLEEGLFQGLSHLWDLNLGWNSLVVLPDTVFQGLGNLHE 198

  Fly   156 LGLQGNAIAEILSSTLDPLMELVHLDLSRNELTTLPQNIFAKNKKLQTLLLNGNPLRILMPDVLG 220
            |.|.||.:..:..:....|.||..||||||.|.::..|:|....:||.|.|:.|.:..:.|....
  Rat   199 LVLAGNKLTYLQPALFCGLGELRELDLSRNALRSVKANVFVHLPRLQKLYLDRNLITAVAPRAFL 263

  Fly   221 SLPNLRLLDLGH----------------------------------------------------- 232
            .:..||.|||.|
  Rat   264 GMKALRWLDLSHNRVAGLMEDTFPGLLGLHVLRLAHNAIASLRPRTFKDLHFLEELQLGHNRIRQ 328

  Fly   233 --------AAELEVMTLN--------------LTNVQNLVLEGSSLSSLV--INGGFIKLQAGNN 273
                    ..:|||:|||              |.||..:.|.|:.|.||.  :..|..||.:.:.
  Rat   329 LGERTFEGLGQLEVLTLNDNQITEVRVGAFSGLFNVAVMNLSGNCLRSLPERVFQGLDKLHSLHL 393

  Fly   274 E---LNHLQV---GNKSSVIEMDLHGNLLNGNDTAALLRGMWNLQRLDLSKNRIEALPQHGSGLD 332
            |   |.|:::   ...|.:..:.|..|.::..:..: |.|:..|..|||:.||:..||:
  Rat   394 EHSCLGHVRLHTFAGLSGLRRLFLRDNSISSIEEQS-LAGLSELLELDLTTNRLTHLPR------ 451

  Fly   333 ASGTQELLILPSLKFLNLANNQLVRLPPE--SPILSSRLSYLDLSHNLMLTLDVAILRSLSVLKG 395
                |....|..|::|.|:.|||..|..|  .|:  .|..:||:|||.:.||...:..||..|:.
  Rat   452 ----QLFQGLGHLEYLLLSYNQLTTLSAEVLGPL--QRAFWLDISHNHLETLAEGLFSSLGRLRY 510

  Fly   396 LYVEGNRLNTINYQKLHEEHPDLSELGLHDNPW 428
            |.:..|.|.|.:.|      |.|..|.|..|||
  Rat   511 LSLRNNSLQTFSPQ------PGLERLWLDANPW 537

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG18249	NP_001163549.1	leucine-rich repeat	57..80	CDD:275380	6/28 (21%)
		LRR	105..433	CDD:443914	111/409 (27%)
		leucine-rich repeat	105..128	CDD:275380	7/22 (32%)
		leucine-rich repeat	129..152	CDD:275380	8/22 (36%)
		leucine-rich repeat	153..176	CDD:275380	6/22 (27%)
		leucine-rich repeat	177..200	CDD:275380	10/22 (45%)
		leucine-rich repeat	201..224	CDD:275380	6/22 (27%)
		leucine-rich repeat	225..258	CDD:275380	18/107 (17%)
		leucine-rich repeat	259..310	CDD:275380	12/58 (21%)
		leucine-rich repeat	311..344	CDD:275380	10/32 (31%)
		leucine-rich repeat	345..368	CDD:275380	9/24 (38%)
		leucine-rich repeat	369..390	CDD:275380	7/20 (35%)
		leucine-rich repeat	393..417	CDD:275380	6/23 (26%)
Igfals	NP_445781.3	LRRNT	40..78	CDD:214470	8/37 (22%)
		leucine-rich repeat	57..75	CDD:275380	5/17 (29%)
		LRR 1	75..96		2/20 (10%)
		leucine-rich repeat	79..99	CDD:275380	3/26 (12%)
		LRR	85..476	CDD:443914	100/409 (24%)
		LRR 2	99..120		6/21 (29%)
		leucine-rich repeat	103..123	CDD:275380	6/20 (30%)
		LRR 3	123..144		4/20 (20%)
		LRR 4	147..168		7/20 (35%)
		LRR 5	171..192		5/20 (25%)
		leucine-rich repeat	175..195	CDD:275380	7/19 (37%)
		LRR 6	195..216		5/20 (25%)
		leucine-rich repeat	196..219	CDD:275380	6/22 (27%)
		LRR 7	219..240		11/20 (55%)
		leucine-rich repeat	220..243	CDD:275380	10/22 (45%)
		LRR 8	243..264		6/20 (30%)
		leucine-rich repeat	244..267	CDD:275380	6/22 (27%)
		LRR 9	267..288		6/20 (30%)
		leucine-rich repeat	268..291	CDD:275380	6/22 (27%)
		LRR 10	291..312		0/20 (0%)
		leucine-rich repeat	292..315	CDD:275380	0/22 (0%)
		LRR 11	315..336		0/20 (0%)
		leucine-rich repeat	316..339	CDD:275380	0/22 (0%)
		LRR 12	339..360		6/20 (30%)
		leucine-rich repeat	340..363	CDD:275380	7/22 (32%)
		LRR 13	363..384		7/20 (35%)
		leucine-rich repeat	364..387	CDD:275380	7/22 (32%)
		LRR 14	387..408		5/20 (25%)
		leucine-rich repeat	388..411	CDD:275380	4/22 (18%)
		LRR 15	411..432		3/21 (14%)
		leucine-rich repeat	412..435	CDD:275380	4/23 (17%)
		LRR 16	435..456		9/30 (30%)
		leucine-rich repeat	436..459	CDD:275380	10/32 (31%)
		LRR 17	459..480		8/20 (40%)
		leucine-rich repeat	460..481	CDD:275380	8/20 (40%)
		LRR 18	483..504		8/20 (40%)
		leucine-rich repeat	484..507	CDD:275380	9/22 (41%)
		LRR_8	486..536	CDD:404697	19/55 (35%)
		LRR 19	507..528		7/26 (27%)
		LRRCT	535..578	CDD:214507	3/3 (100%)