DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG18249 and Tollo

DIOPT Version :9

Sequence 1:	NP_001163549.1	Gene:	CG18249 / 40964	FlyBaseID:	FBgn0037553	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	NP_524757.1	Gene:	Tollo / 44497	FlyBaseID:	FBgn0029114	Length:	1346	Species:	Drosophila melanogaster

Alignment Length:	472	Identity:	120/472 - (25%)
Similarity:	213/472 - (45%)	Gaps:	85/472 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 ICGLTVSDALAVYDASGRFNLSASCPDSFCSLSDRPVAYSATPALQLRELHLRNCSRQSITWLVL 75
            :||.|    |...|.|.  |...|.|.:..|...|..             || |.::.|:::|..
  Fly   207 VCGST----LQSLDLSA--NKMVSLPTAMLSALGRLT-------------HL-NMAKNSMSFLAD 251

  Fly    76 QLTPGLRTLVIRNCATYHISKESLRP-----VENLTSLQMQGTSLGVLRDQIFNAVPRLEILQLS 135
            :...||.:|.:.:.:...::  ||.|     .:.|..:.::..|:.||...||..:..|.:|.|:
  Fly   252 RAFEGLLSLRVVDLSANRLT--SLPPELFAETKQLQEIYLRNNSINVLAPGIFGELAELLVLDLA 314

  Fly   136 QNFIHT--VHVAAFQGLSKLRLLGLQGNAIAEILSSTLDPLMELVHLDLSRNELTTLPQNIFAKN 198
            .|.:::  ::.|.|.||.:|.:|.|..|.|:.:.:....||..|..|.|..|.:..||..|||..
  Fly   315 SNELNSQWINAATFVGLKRLMMLDLSANKISRLEAHIFRPLASLQILKLEDNYIDQLPGGIFADL 379

  Fly   199 KKLQTLLLNGNPLRILMPDVLGSLPNLRL--LDLGHAAELEVMTL-NLTNVQNLVLEGSSLSSL- 259
            ..|.||:|:.|.:.::....|..|.||.:  ||....:.::..:| |.:.:|:|.|..:.|.::
  Fly   380 TNLHTLILSRNRISVIEQRTLQGLKNLLVLSLDFNRISRMDQRSLVNCSQLQDLHLNDNKLQAVP 444

  Fly   260 --VINGGFIK-LQAGNNELNHLQVGNKSSVIEMD-LHGNLLNGNDTAALLRG----MWNLQRLDL 316
              :.:...:| |..|.|.::.::   .:|:.::: |:|..:..|....:.||    |.:||.|:|
  Fly   445 EALAHVQLLKTLDVGENMISQIE---NTSITQLESLYGLRMTENSLTHIRRGVFDRMSSLQILNL 506

  Fly   317 SKNRIEALP----QHGSGLDA---SGTQELLI------LPSLKFLNLANNQLVR-----LPPESP 363
            |:|:::::.    |..|.|.|   .|.|...|      ||:|.:||::.|:|.:     :|....
  Fly   507 SQNKLKSIEAGSLQRNSQLQAIRLDGNQLKSIAGLFTELPNLVWLNISGNRLEKFDYSHIPIGLQ 571

  Fly   364 ILSSR------------------LSYLDLSHNLMLTLDV-AILRSLSVLKGLYVEGNRLNTINYQ 409
            .|..|                  ||..|.|:||:..:.. :|..|:.|   ||:..|:::.|...
  Fly   572 WLDVRANRITQLGNYFEIESELSLSTFDASYNLLTEITASSIPNSVEV---LYLNDNQISKIQPY 633

  Fly   410 KLHEEHPDLSELGLHDN 426
            ...:: |:|:.:.|..|
  Fly   634 TFFKK-PNLTRVDLVRN 649

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18249	NP_001163549.1	leucine-rich repeat	57..80	CDD:275380	5/22 (23%)
		LRR_8	104..163	CDD:290566	18/60 (30%)
		leucine-rich repeat	105..128	CDD:275380	6/22 (27%)
		LRR_RI	107..438	CDD:238064	97/371 (26%)
		leucine-rich repeat	129..152	CDD:275380	8/24 (33%)
		leucine-rich repeat	153..176	CDD:275380	7/22 (32%)
		LRR_8	176..232	CDD:290566	20/57 (35%)
		leucine-rich repeat	177..200	CDD:275380	9/22 (41%)
		leucine-rich repeat	201..224	CDD:275380	7/22 (32%)
		leucine-rich repeat	225..258	CDD:275380	9/35 (26%)
		leucine-rich repeat	259..310	CDD:275380	11/59 (19%)
		leucine-rich repeat	311..344	CDD:275380	14/45 (31%)
		LRR_8	343..403	CDD:290566	21/83 (25%)
		leucine-rich repeat	345..368	CDD:275380	7/27 (26%)
		leucine-rich repeat	369..390	CDD:275380	7/21 (33%)
		leucine-rich repeat	393..417	CDD:275380	4/23 (17%)
Tollo	NP_524757.1	LRR_RI	<85..281	CDD:238064	22/95 (23%)
		leucine-rich repeat	100..123	CDD:275380
		leucine-rich repeat	124..144	CDD:275380
		LRR_8	152..222	CDD:290566	7/20 (35%)
		leucine-rich repeat	154..177	CDD:275380
		leucine-rich repeat	178..201	CDD:275380
		LRR	210..656	CDD:227223	118/469 (25%)
		leucine-rich repeat	212..235	CDD:275380	7/24 (29%)
		leucine-rich repeat	236..259	CDD:275380	7/36 (19%)
		leucine-rich repeat	260..283	CDD:275380	4/24 (17%)
		LRR_RI	276..558	CDD:238064	77/284 (27%)
		leucine-rich repeat	284..307	CDD:275380	6/22 (27%)
		leucine-rich repeat	308..333	CDD:275380	8/24 (33%)
		leucine-rich repeat	334..357	CDD:275380	7/22 (32%)
		leucine-rich repeat	358..381	CDD:275380	9/22 (41%)
		leucine-rich repeat	382..405	CDD:275380	7/22 (32%)
		leucine-rich repeat	406..429	CDD:275380	5/22 (23%)
		leucine-rich repeat	430..452	CDD:275380	4/21 (19%)
		leucine-rich repeat	453..500	CDD:275380	11/49 (22%)
		leucine-rich repeat	501..521	CDD:275380	6/19 (32%)
		leucine-rich repeat	525..547	CDD:275380	6/21 (29%)
		leucine-rich repeat	548..573	CDD:275380	6/24 (25%)
		leucine-rich repeat	604..640	CDD:275380	8/39 (21%)
		leucine-rich repeat	641..688	CDD:275380	3/9 (33%)
		leucine-rich repeat	689..816	CDD:275380
		LRR_8	815..875	CDD:290566
		leucine-rich repeat	817..864	CDD:275380
		LRR_8	864..921	CDD:290566
		leucine-rich repeat	865..888	CDD:275380
		leucine-rich repeat	889..910	CDD:275380
		TIR	1076..1211	CDD:214587
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453670
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840