Protein Alignment CG18249 and Tl

DIOPT Version :10

• Sequence 1: NP_001163549.1
• Gene: CG18249 / 40964
• FlyBaseID: FBgn0037553
• Length: 559
• Species: Drosophila melanogaster
• Sequence 2: NP_001262995.1
• Gene: Tl / 43222
• FlyBaseID: FBgn0262473
• Length: 1117
• Species: Drosophila melanogaster
• Alignment Length: 408
• Identity: 105/408 - (25%)
• Similarity: 171/408 - (41%)
• Gaps: 77/408 - (18%)

  Fly   102 VENLTSLQMQGTSLGVLRDQIFNAVPRLEILQLSQNFIHTVHVAAFQGLSKLRLLGLQGNAIAEI 166
            :|||.|::.....|..:...||..:|:|:.|.|..|.:|.:....|:|.:.:..:.:..|.|.::
  Fly   196 LENLESIEFGSNKLRQMPRGIFGKMPKLKQLNLWSNQLHNLTKHDFEGATSVLGIDIHDNGIEQL 260

  Fly   167 LSSTLDPLMELVHLDLSRNELTTLPQNIFAKNKKLQTLLLNGN--PLRILMPDVLGSLPNLRLLD 229
            .......|..:..::||.|...:|||.:|..||.|..:.|..|  ||..|...:..:.|.|::|.
  Fly   261 PHDVFAHLTNVTDINLSANLFRSLPQGLFDHNKHLNEVRLMNNRVPLATLPSRLFANQPELQILR 325

  Fly   230 LGHAAELEVMTLNL----TNVQNLVLEGSSLSSL-------VINGGFIKLQAGNNELNHLQ---V 280
            |  .|||:.:..:|    |.:.|:.|..:.|.:|       .:|  .:.|...||.|.||.   .
  Fly   326 L--RAELQSLPGDLFEHSTQITNISLGDNLLKTLPATLLEHQVN--LLSLDLSNNRLTHLPDSLF 386

  Fly   281 GNKSSVIEMDLHGNLLNGNDTAALLRGMWNLQRLDLSKNRIEALPQHG----SGL--------DA 333
            .:.:::.::.|..|||.| .:..:...:.||..|.:|:||:..:....    :||        |.
  Fly   387 AHTTNLTDLRLEDNLLTG-ISGDIFSNLGNLVTLVMSRNRLRTIDSRAFVSTNGLRHLHLDHNDI 450

  Fly   334 SGTQELL-------------ILPSLKFLNLANNQLVRLPPESPILSSRLSYLDLSHNLMLTL--- 382
            ...|.||             .:..|..|||.||.::.:..:......:|..||||:|.:.:|
  Fly   451 DLQQPLLDIMLQTQINSPFGYMHGLLTLNLRNNSIIFVYNDWKNTMLQLRELDLSYNNISSLGYE 515

  Fly   383 DVAILRSLSVLKGLYVEGNRL------NTINYQKLHEE-------HPDLSELGLHDNPWSSGLYR 434
            |:|.|..           |||      |.|....|.|:       :.:|..:.|:|||.......
  Fly   516 DLAFLSQ-----------NRLHVNMTHNKIRRIALPEDVHLGEGYNNNLVHVDLNDNPLVCDCTI 569

  Fly   435 KMFLYFTDRGVHLQARPQ 452
            ..|:... ||||   :||
  Fly   570 LWFIQLV-RGVH---KPQ 583

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG18249	NP_001163549.1	leucine-rich repeat	57..80	CDD:275380
		LRR	105..433	CDD:443914	96/384 (25%)
		leucine-rich repeat	105..128	CDD:275380	5/22 (23%)
		leucine-rich repeat	129..152	CDD:275380	7/22 (32%)
		leucine-rich repeat	153..176	CDD:275380	3/22 (14%)
		leucine-rich repeat	177..200	CDD:275380	8/22 (36%)
		leucine-rich repeat	201..224	CDD:275380	6/24 (25%)
		leucine-rich repeat	225..258	CDD:275380	11/36 (31%)
		leucine-rich repeat	259..310	CDD:275380	13/60 (22%)
		leucine-rich repeat	311..344	CDD:275380	11/57 (19%)
		leucine-rich repeat	345..368	CDD:275380	6/22 (27%)
		leucine-rich repeat	369..390	CDD:275380	10/23 (43%)
		leucine-rich repeat	393..417	CDD:275380	7/36 (19%)
Tl	NP_001262995.1	LRR_8	174..233	CDD:404697	12/36 (33%)
		leucine-rich repeat	176..198	CDD:275380	0/1 (0%)
		leucine-rich repeat	199..222	CDD:275380	5/22 (23%)
		LRR	222..576	CDD:443914	91/369 (25%)
		leucine-rich repeat	223..270	CDD:275380	10/46 (22%)
		leucine-rich repeat	271..294	CDD:275380	8/22 (36%)
		leucine-rich repeat	295..320	CDD:275380	6/24 (25%)
		leucine-rich repeat	321..343	CDD:275380	7/23 (30%)
		leucine-rich repeat	344..367	CDD:275380	4/22 (18%)
		leucine-rich repeat	368..391	CDD:275380	6/22 (27%)
		leucine-rich repeat	392..415	CDD:275380	5/23 (22%)
		leucine-rich repeat	416..439	CDD:275380	5/22 (23%)
		leucine-rich repeat	440..474	CDD:275380	5/33 (15%)
		leucine-rich repeat	475..498	CDD:275380	6/22 (27%)
		leucine-rich repeat	499..520	CDD:275380	9/20 (45%)
		leucine-rich repeat	523..552	CDD:275380	7/28 (25%)
		LRRCT	561..619	CDD:214507	9/27 (33%)
		LRRNT	631..667	CDD:214470
		PPP1R42	<660..752	CDD:455733
		leucine-rich repeat	664..693	CDD:275380
		leucine-rich repeat	694..715	CDD:275380
		leucine-rich repeat	716..737	CDD:275380
		LRRCT	751..800	CDD:214507
		TIR	858..996	CDD:214587