Protein Alignment CG18249 and alrm

DIOPT Version :10

• Sequence 1: NP_001163549.1
• Gene: CG18249 / 40964
• FlyBaseID: FBgn0037553
• Length: 559
• Species: Drosophila melanogaster
• Sequence 2: NP_651393.1
• Gene: alrm / 43074
• FlyBaseID: FBgn0039332
• Length: 471
• Species: Drosophila melanogaster
• Alignment Length: 533
• Identity: 126/533 - (23%)
• Similarity: 194/533 - (36%)
• Gaps: 144/533 - (27%)

  Fly    46 PVAYSATPAL---QLRELHLRNCSRQSITWLVLQLTPGLRTLVIRNCATYHISKESLRPVENLTS 107
            |..:.|||:.   |||.|           ||....:.|:.|.|:...:.|.|..::  |:...|.
  Fly    18 PSYHLATPSSGSGQLRRL-----------WLQDHCSAGICTNVVIGRSDYVILSQA--PIGGTTM 69

  Fly   108 LQMQGTSLGVLRDQIFNAVPRLEILQLSQNFIHTVHVAAFQGLSKL--------RL--------- 155
            |....:|:..:...:|:..|.|::|::....:.|.....|:|.|.|        ||
  Fly    70 LTFLNSSIAKIPHLLFDTFPDLQVLRMENCSLETFEKPQFEGASNLMSLFLGYNRLKDIPKNIFL 134

  Fly   156 -------LGLQGNAIAEILSSTLDPLMELVHLDLSRNELTTLPQNIFAKNKKLQTLLLNGNPLRI 213
                   |.||||.:.::.:.:...|.|:..|.|:.|:|..:...:|:..:||..|.|.||.|..
  Fly   135 GADNLATLHLQGNQLKQLGNHSFHALKEVKELSLAENQLEQISLGVFSGMRKLMDLNLAGNRLDA 199

  Fly   214 LMPDVLGSLPNLRLLDLGH----AAELEV-------------------MTLNLTNVQNLVLEGSS 255
            |...|.....||..|:|..    |.|.|:                   :|||.|.:...:.....
  Fly   200 LPRGVFDRNLNLTKLNLARNRFTAFESELLKLQPVFTQLDISGNIFQELTLNFTMLDVAIAHSCD 264

  Fly   256 LSSLVINGGFIKLQAGNN---ELNHLQVGNKSSVIEMDLHGNLLNGNDTAALLRGMWNLQRLDLS 317
            |..|.:.|...:|...||   |:.|:.:.  ::|..:||..|.| ||.....||...:|.||:||
  Fly   265 LRRLTVYGVIHELDLHNNSLREMPHIPLA--ANVSSLDLSHNPL-GNLQGNPLRRFTSLLRLNLS 326

  Fly   318 KNRIEALPQHGSGLDASGTQELLILPSLKFLNLANNQLVRLPPESPI-LSSRLSYLDLSHNLMLT 381
                           |:|..||                    ||... ..|.|..||:|.|.:.:
  Fly   327 ---------------ATGAHEL--------------------PEGLFKKQSHLQMLDISGNSIYS 356

  Fly   382 LDVAILRSLSVLKGLYVEGNRLNTINYQKLHEEHPDLSELGLHDNPWSSGLYRKMFLYFTDRGVH 446
            |.:.|..||..|:..|.:.|..|....|.|                .||.:.||...:..|
  Fly   357 LKITIFDSLKALQYFYFQQNNWNCDFLQLL----------------MSSFVKRKDISFMED---- 401

  Fly   447 LQARPQNRVLNKSSRVD--ID----WPPNEGQAEAQKMDPPGVTGIHPYWTLRDILAFVTLLVVM 505
                     :.....||  :|    |  .|...:::|.:..|.........:|:.:...|.||..
  Fly   402 ---------ITAPELVDDYVDGIACW--YESDKQSKKCESGGSDAAMELSVVRNEIKTFTELVEK 455

  Fly   506 IILLMNLYHILEE 518
              ..:.:|.:|||
  Fly   456 --KFVKVYRMLEE 466

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG18249	NP_001163549.1	leucine-rich repeat	57..80	CDD:275380	5/22 (23%)
		LRR	105..433	CDD:443914	92/378 (24%)
		leucine-rich repeat	105..128	CDD:275380	4/22 (18%)
		leucine-rich repeat	129..152	CDD:275380	5/22 (23%)
		leucine-rich repeat	153..176	CDD:275380	9/46 (20%)
		leucine-rich repeat	177..200	CDD:275380	5/22 (23%)
		leucine-rich repeat	201..224	CDD:275380	8/22 (36%)
		leucine-rich repeat	225..258	CDD:275380	11/55 (20%)
		leucine-rich repeat	259..310	CDD:275380	16/53 (30%)
		leucine-rich repeat	311..344	CDD:275380	9/32 (28%)
		leucine-rich repeat	345..368	CDD:275380	2/23 (9%)
		leucine-rich repeat	369..390	CDD:275380	7/20 (35%)
		leucine-rich repeat	393..417	CDD:275380	6/23 (26%)
alrm	NP_651393.1	leucine-rich repeat	91..114	CDD:275380	5/22 (23%)
		LRR	<100..426	CDD:443914	93/394 (24%)
		leucine-rich repeat	115..138	CDD:275380	3/22 (14%)
		leucine-rich repeat	139..162	CDD:275380	6/22 (27%)
		leucine-rich repeat	163..186	CDD:275380	5/22 (23%)
		leucine-rich repeat	187..210	CDD:275380	8/22 (36%)
		leucine-rich repeat	211..283	CDD:275380	15/71 (21%)
		leucine-rich repeat	284..319	CDD:275380	11/37 (30%)
		leucine-rich repeat	320..343	CDD:275380	11/57 (19%)
		leucine-rich repeat	344..365	CDD:275380	7/20 (35%)