DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18249 and cDIP

DIOPT Version :9

Sequence 1:	NP_001163549.1	Gene:	CG18249 / 40964	FlyBaseID:	FBgn0037553	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	NP_650951.1	Gene:	cDIP / 42512	FlyBaseID:	FBgn0038865	Length:	554	Species:	Drosophila melanogaster

Alignment Length:	375	Identity:	96/375 - (25%)
Similarity:	158/375 - (42%)	Gaps:	43/375 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 CSLSDRPVAYSATPALQLRELHLRNCSRQSITWLVLQLTPGLRTLVIRNCATYHISKESLRPVEN 104
            |:.::.|:....|  |::.||.:|.|..:.|.|....:  |...|||...:..||.
  Fly   103 CTFTNFPLRLFYT--LEVSELDMRGCGIRFIYWENFSI--GADKLVILLLSDNHIE--------- 154

  Fly   105 LTSLQMQGTSLGVLRDQIFNAVPRLEILQLSQNFIHTVHVAAFQGLSKLRLLGLQGNAIAEILSS 169
                        ||..:.|.....||.:.|::|.:..:...||..|.||:.|.|..|.:..:.:.
  Fly   155 ------------VLPTKTFRGAGNLEFIFLNRNKLGKLQAGAFDNLLKLQYLDLTENRLEALAAD 207

  Fly   170 TLDPLMELVHLDLSRNELTTLPQNIFAKNKKLQTLLLNGNPLRILMPDVL---GSLPNLRLLDLG 231
            ....|..|.|:.|:.|:|||:..::||.|..|.::.:..|.||.:.....   |....::.:||.
  Fly   208 VFAGLKSLRHVGLAGNQLTTIESDLFAHNPDLLSVAMQNNRLREVGEYAFRSRGRHHQMQYVDLS 272

  Fly   232 HAAELEVMTLNLTNVQNLVLEGSSLSSLVINGGFIKLQAGNNELNHLQVGNKSSVIEMDLHGNLL 296
            :..||.|:.||: |..||.....||..:.:.|....:...:|.:..|......::..:.|..|.|
  Fly   273 NNPELVVLLLNI-NATNLTARNCSLDRVNLYGSVTNVDLSDNRVRELYFPASEALEHLVLRNNSL 336

  Fly   297 NGNDTAALLRGMWNLQRLDLSKNRIEALPQHGSGLDASGTQELLILPSLKFLNLANNQLVRLPPE 361
              ...|:|.| :..|:.||::.|     |..|...|...|      |.|:.|.|.|...:.||.|
  Fly   337 --VQLASLSR-VPRLRHLDVADN-----PNLGQLPDGWRT------PHLEMLVLRNTGQMELPLE 387

  Fly   362 SPILSSRLSYLDLSHNLMLTLDVAILRSLSVLKGLYVEGNRLNTINYQKL 411
            :......|..||:|.|.:..:|.:...:|:.|...|:.||..|..:.:.:
  Fly   388 ALQGMQNLQKLDISGNNLTEIDPSAFPTLTQLTHFYIHGNNWNCFSLRNI 437

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18249	NP_001163549.1	leucine-rich repeat	57..80	CDD:275380	6/22 (27%)
		LRR_8	104..163	CDD:290566	15/58 (26%)
		leucine-rich repeat	105..128	CDD:275380	3/22 (14%)
		LRR_RI	107..438	CDD:238064	80/308 (26%)
		leucine-rich repeat	129..152	CDD:275380	7/22 (32%)
		leucine-rich repeat	153..176	CDD:275380	5/22 (23%)
		LRR_8	176..232	CDD:290566	17/58 (29%)
		leucine-rich repeat	177..200	CDD:275380	10/22 (45%)
		leucine-rich repeat	201..224	CDD:275380	5/25 (20%)
		leucine-rich repeat	225..258	CDD:275380	12/32 (38%)
		leucine-rich repeat	259..310	CDD:275380	9/50 (18%)
		leucine-rich repeat	311..344	CDD:275380	8/32 (25%)
		LRR_8	343..403	CDD:290566	19/59 (32%)
		leucine-rich repeat	345..368	CDD:275380	7/22 (32%)
		leucine-rich repeat	369..390	CDD:275380	6/20 (30%)
		leucine-rich repeat	393..417	CDD:275380	5/19 (26%)
cDIP	NP_650951.1	leucine-rich repeat	118..142	CDD:275380	7/25 (28%)
		LRR_RI	143..407	CDD:238064	78/299 (26%)
		leucine-rich repeat	143..166	CDD:275380	8/43 (19%)
		LRR_8	166..225	CDD:290566	17/58 (29%)
		leucine-rich repeat	167..190	CDD:275380	7/22 (32%)
		leucine-rich repeat	191..214	CDD:275380	5/22 (23%)
		leucine-rich repeat	215..238	CDD:275380	10/22 (45%)
		leucine-rich repeat	239..265	CDD:275380	5/25 (20%)
		leucine-rich repeat	266..325	CDD:275380	15/59 (25%)
		LRR_8	304..357	CDD:290566	12/60 (20%)
		leucine-rich repeat	326..347	CDD:275380	6/23 (26%)
		leucine-rich repeat	348..394	CDD:275380	16/56 (29%)
		LRR_8	369..428	CDD:290566	18/58 (31%)
		LRR_4	393..433	CDD:289563	12/39 (31%)
		leucine-rich repeat	395..418	CDD:275380	7/22 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45443095
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840