DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18249 and CG6749

DIOPT Version :9

Sequence 1:	NP_001163549.1	Gene:	CG18249 / 40964	FlyBaseID:	FBgn0037553	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	NP_648354.1	Gene:	CG6749 / 39144	FlyBaseID:	FBgn0036040	Length:	552	Species:	Drosophila melanogaster

Alignment Length:	458	Identity:	116/458 - (25%)
Similarity:	191/458 - (41%)	Gaps:	93/458 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 YSATPALQLRELHLRNC---------------------SRQSITWLVLQLTPGLRTLVIRNCATY 92
            :|..|  .||:|:|..|                     |...:..|.......||.|:..|.:..
  Fly   100 FSILP--NLRQLNLSGCGLVDIRGNHFAPESALQRIDFSHNQMELLDRDFFGNLRKLIYANFSHN 162

  Fly    93 HISKESLRPVENLTSLQMQGTSLGVLRDQIFNAVPRLEILQLSQNFIHTVHVAAFQGLSKLRLLG 157
            .:.:..|..:..|..|::....   |.:..|...|:|:.|.|:.|.:..:.|.||:||..|..|.
  Fly   163 ALKQCDLPHMPLLNRLELGHNR---LVNATFGVCPQLQELILNDNQLIQLDVNAFRGLHGLLELQ 224

  Fly   158 LQGNAIAEILSSTLDPLMELVHLDLSRNELTTLPQNIFAKNKK----LQTLLLNGNPLRILMPDV 218
            |.||.::.|...|..||.:|..|:||:|.|..|..|:|...:.    ||.|.|:||.:|:|..:.
  Fly   225 LSGNRLSSIGLETFQPLAQLRKLNLSQNALDALRPNVFGAVQNFVLHLQQLDLSGNRIRLLFDNQ 289

  Fly   219 LGSLPNLRLLDLGHAAELEVMTLNLTNVQNLVLEGSSLSSL-----VINGGFIKLQAGNNELNHL 278
            ...|..|::||:..                     :|::||     |..|...||....|.:..:
  Fly   290 FRVLARLQMLDVSR---------------------NSIASLSPAHFVGLGSLRKLYLQYNAILEI 333

  Fly   279 QVGNKSSVIEMDL----HGNL------LNGNDTAALLRGMWNLQRLDLSKNRIEALPQHGSGLDA 333
            :....::::.:|.    :.||      :.|.:|...:|      ||:|:.||::.|  |.....:
  Fly   334 KPATFAALLNLDTLDLSYNNLEFLEEQIFGGNTLPRMR------RLNLNGNRMKHL--HPLAFSS 390

  Fly   334 SGTQELLILPSLKFLNLANNQLVRLPPESPILSSRLSYLDLSHNLMLTLDVAILRSLSVLKGLYV 398
                    ||.|::|.|.:|:|..|.........||..|.|.|||:..:::.:|.|||.::.:.|
  Fly   391 --------LPFLEYLKLGHNELKSLDVRMFAPMRRLQKLHLGHNLLEEINLDVLESLSSVQEILV 447

  Fly   399 EGNRLNTINYQKLHEEHPDLSELGLHDNPWSSGLYRKM--------FLYFTDR-GVHLQARPQNR 454
            :.|||..:  .|::...|:|..:.:..|||....:.|:        .:|..|. |.:...||...
  Fly   448 DNNRLTFL--AKVNVSFPNLKRVAIEGNPWQCPCFVKLQHWLATRDVVYLRDNTGYYKGERPLCI 510

  Fly   455 VLN 457
            |.|
  Fly   511 VTN 513

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18249	NP_001163549.1	leucine-rich repeat	57..80	CDD:275380	7/43 (16%)
		LRR_8	104..163	CDD:290566	19/58 (33%)
		leucine-rich repeat	105..128	CDD:275380	4/22 (18%)
		LRR_RI	107..438	CDD:238064	94/357 (26%)
		leucine-rich repeat	129..152	CDD:275380	9/22 (41%)
		leucine-rich repeat	153..176	CDD:275380	9/22 (41%)
		LRR_8	176..232	CDD:290566	21/59 (36%)
		leucine-rich repeat	177..200	CDD:275380	9/22 (41%)
		leucine-rich repeat	201..224	CDD:275380	9/22 (41%)
		leucine-rich repeat	225..258	CDD:275380	4/32 (13%)
		leucine-rich repeat	259..310	CDD:275380	12/65 (18%)
		leucine-rich repeat	311..344	CDD:275380	8/32 (25%)
		LRR_8	343..403	CDD:290566	20/59 (34%)
		leucine-rich repeat	345..368	CDD:275380	6/22 (27%)
		leucine-rich repeat	369..390	CDD:275380	7/20 (35%)
		leucine-rich repeat	393..417	CDD:275380	5/23 (22%)
CG6749	NP_648354.1	LRR_RI	103..>256	CDD:238064	42/157 (27%)
		LRR_8	104..164	CDD:290566	12/61 (20%)
		leucine-rich repeat	106..129	CDD:275380	5/22 (23%)
		leucine-rich repeat	130..153	CDD:275380	3/22 (14%)
		leucine-rich repeat	154..195	CDD:275380	7/43 (16%)
		LRR_RI	194..455	CDD:238064	84/297 (28%)
		LRR_8	194..254	CDD:290566	24/59 (41%)
		leucine-rich repeat	196..219	CDD:275380	9/22 (41%)
		leucine-rich repeat	220..243	CDD:275380	9/22 (41%)
		leucine-rich repeat	244..267	CDD:275380	9/22 (41%)
		LRR_8	271..330	CDD:290566	20/79 (25%)
		leucine-rich repeat	272..295	CDD:275380	9/22 (41%)
		leucine-rich repeat	296..319	CDD:275380	7/43 (16%)
		LRR_8	319..380	CDD:290566	13/66 (20%)
		leucine-rich repeat	320..343	CDD:275380	3/22 (14%)
		leucine-rich repeat	344..369	CDD:275380	5/24 (21%)
		LRR_8	368..428	CDD:290566	22/75 (29%)
		leucine-rich repeat	370..393	CDD:275380	9/38 (24%)
		leucine-rich repeat	394..417	CDD:275380	6/22 (27%)
		leucine-rich repeat	418..441	CDD:275380	9/22 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453598
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840