DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18249 and ltl

DIOPT Version :9

Sequence 1:	NP_001163549.1	Gene:	CG18249 / 40964	FlyBaseID:	FBgn0037553	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	NP_001261524.1	Gene:	ltl / 38845	FlyBaseID:	FBgn0268063	Length:	817	Species:	Drosophila melanogaster

Alignment Length:	463	Identity:	111/463 - (23%)
Similarity:	181/463 - (39%)	Gaps:	121/463 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 QLRELHLR-------NCSRQSITWLVLQLTPGLRTLVIRNCATYHISKESLRPVENLTSLQMQGT 113
            ||.:|.:|       |..:..:.|..|:..|                :...|.:.|:|.|.:...
  Fly    71 QLDDLEMRSFTDMNFNLYKLRMQWNSLKSLP----------------EVPFRGLSNVTYLSIGDN 119

  Fly   114 SLGVLRDQIFNAVPRLEILQLSQNFIHTVHVAAFQGLSKLRLLGLQGNAIAEILSSTLDPLMELV 178
            .|..:.....:.:|.|..|.:.:..|..|....|:|:.::..|.|..|.|..:...:....:.::
  Fly   120 DLDEIPKHALSHMPSLLTLDIGRCKIRAVQQEDFRGIQRVTNLILVSNIITRLDRGSFPKSLLIL 184

  Fly   179 HLDLSRNELTTLPQNIFAKNKKLQTLLLNGNPLRILMPDVLGSLPNLRLLDLGHAAELEVMTLNL 243
            |  |.||:|.:|..::...: .|::|.:|.|.:..| .|.|.....|||| :.|...||.:..|:
  Fly   185 H--LGRNQLESLNGSLHDLH-NLESLFINANNITSL-DDELPDGGQLRLL-MAHNNRLERLPANM 244

  Fly   244 TNVQNLV---LEGSSLSSL------VINGGFIKLQAGNNEL---------------------NHL 278
            ..:.:|.   :..:.|.|.      .:|  ..::.|.||||                     ||:
  Fly   245 AGMHSLETVHIHCNQLRSFDRVLRNAVN--LSEVMADNNELEYLAQDEFASCSKVETLQMGCNHI 307

  Fly   279 QVGNKSSVIEMDLHGNLLNGND----TAALLRGMWNLQRLDLSKNRIE-ALPQHGSGLDASGTQE 338
            :..|.|.:..:.|.....:.||    :.|.|.|:.:|:.|.||.|||: .||      |..|.||
  Fly   308 KSLNSSLLPILKLKNANFSFNDIEEFSMAELHGLRSLKTLQLSSNRIQRLLP------DPRGVQE 366

  Fly   339 LLI-------------------LPSLKFLNLANNQLVRLPPESPILSSRLSYLDLSHNLML---T 381
            |::                   |.:|:.||||.|:|..|.........||..|||:.|.:.   .
  Fly   367 LMLVNLDLDNNRIDSLNGALAGLGNLRILNLAGNRLEHLQVGDFDGMIRLDILDLTGNQLAELKP 431

  Fly   382 LDVAILRSLSVLKGLY--------------------VEGNRLNTINYQ-------KLHEEHPDLS 419
            |::.:|.||.:||..|                    :..|:::||:.:       |.|.. |...
  Fly   432 LEMTLLPSLKILKVAYNNITKLEQDFKGLPVLCQANLTNNQISTISSELVTNTRCKNHNV-PGKL 495

  Fly   420 ELGLHDNP 427
            |:.|.|||
  Fly   496 EIHLDDNP 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18249	NP_001163549.1	leucine-rich repeat	57..80	CDD:275380	6/29 (21%)
		LRR_8	104..163	CDD:290566	14/58 (24%)
		leucine-rich repeat	105..128	CDD:275380	3/22 (14%)
		LRR_RI	107..438	CDD:238064	100/405 (25%)
		leucine-rich repeat	129..152	CDD:275380	6/22 (27%)
		leucine-rich repeat	153..176	CDD:275380	4/22 (18%)
		LRR_8	176..232	CDD:290566	17/55 (31%)
		leucine-rich repeat	177..200	CDD:275380	6/22 (27%)
		leucine-rich repeat	201..224	CDD:275380	7/22 (32%)
		leucine-rich repeat	225..258	CDD:275380	10/35 (29%)
		leucine-rich repeat	259..310	CDD:275380	16/81 (20%)
		leucine-rich repeat	311..344	CDD:275380	15/52 (29%)
		LRR_8	343..403	CDD:290566	22/82 (27%)
		leucine-rich repeat	345..368	CDD:275380	8/22 (36%)
		leucine-rich repeat	369..390	CDD:275380	7/23 (30%)
		leucine-rich repeat	393..417	CDD:275380	8/50 (16%)
ltl	NP_001261524.1	leucine-rich repeat	65..86	CDD:275380	4/14 (29%)
		LRR_8	86..145	CDD:290566	12/74 (16%)
		leucine-rich repeat	87..110	CDD:275380	4/38 (11%)
		leucine-rich repeat	111..134	CDD:275380	3/22 (14%)
		leucine-rich repeat	135..158	CDD:275380	6/22 (27%)
		LRR_8	158..214	CDD:290566	14/58 (24%)
		leucine-rich repeat	159..180	CDD:275380	4/20 (20%)
		leucine-rich repeat	181..203	CDD:275380	6/24 (25%)
		leucine-rich repeat	204..226	CDD:275380	7/22 (32%)
		LRR_RI	226..451	CDD:238064	63/233 (27%)
		leucine-rich repeat	227..249	CDD:275380	8/22 (36%)
		leucine-rich repeat	250..272	CDD:275380	3/21 (14%)
		leucine-rich repeat	273..296	CDD:275380	5/22 (23%)
		leucine-rich repeat	297..315	CDD:275380	4/17 (24%)
		LRR_8	319..402	CDD:290566	27/88 (31%)
		leucine-rich repeat	320..335	CDD:275378	3/14 (21%)
		leucine-rich repeat	344..366	CDD:275380	11/27 (41%)
		leucine-rich repeat	367..391	CDD:275380	2/23 (9%)
		LRR_8	369..426	CDD:290566	15/56 (27%)
		leucine-rich repeat	392..415	CDD:275380	8/22 (36%)
		leucine-rich repeat	416..439	CDD:275380	7/22 (32%)
		LRR_8	438..>479	CDD:290566	8/40 (20%)
		leucine-rich repeat	440..462	CDD:275380	4/21 (19%)
		leucine-rich repeat	463..483	CDD:275380	3/19 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45443098
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930