Protein Alignment CG18249 and Toll-7

DIOPT Version :10

• Sequence 1: NP_001163549.1
• Gene: CG18249 / 40964
• FlyBaseID: FBgn0037553
• Length: 559
• Species: Drosophila melanogaster
• Sequence 2: NP_523797.1
• Gene: Toll-7 / 37272
• FlyBaseID: FBgn0034476
• Length: 1446
• Species: Drosophila melanogaster
• Alignment Length: 622
• Identity: 149/622 - (23%)
• Similarity: 242/622 - (38%)
• Gaps: 185/622 - (29%)

  Fly    12 CGLTVSD---ALAVYDASGRFNLSASCPDSFCSLSDRPVAYSATPALQ-LRELHLRNCSRQSITW 72
            |.|.:.:   .|.:..|.|...|:..|.:.:...|..|||..|  .|| |..|.|.:|.
  Fly    89 CALRLIERQPGLDLQGADGSSQLTIQCSELYLFESTLPVAVFA--RLQTLEALRLDSCK------ 145

  Fly    73 LVLQLT----PGLRTLVIRNCATYH----------ISKESLRPVENLTSLQMQGTSLGVLRDQIF 123
             :|||.    .||.||.....:|::          :..:||..::.||.|.:...:|..|.....
  Fly   146 -LLQLPNNAFEGLATLKSLRLSTHNSEWGPTRTLELFPDSLGGLKQLTDLDLGDNNLRQLPSGFL 209

  Fly   124 NAVPRLEILQLSQNFIHTVHVAAFQ--------------------------------GLSKLRL- 155
            ..|..|::|.|::|.|.|.....|.                                |:|:||.
  Fly   210 CPVGNLQVLNLTRNRIRTAEQMGFADMNCGAGSGSAGSELQVLDASHNELRSISESWGISRLRRL 274

  Fly   156 --LGLQGNAIAEILSSTLDPLMELVHLDLSRNELTTLPQNIFAKNKKLQTLLLNGNPL------- 211
              |.|..|.::|:....|..|..|..::||.|.|.|||:.:||.:|:|:.:.|..|.|
  Fly   275 QHLNLAYNNLSELSGEALAGLASLRIVNLSNNHLETLPEGLFAGSKELREIHLQQNELYELPKGL 339

  Fly   212 -----RILMPDVLGS--------------LPNLRLLDLGHAA-------------ELEVMTLN-- 242
                 ::|:.|:.|:              |..|.:|:|.|.|             .|:::.|.
  Fly   340 FHRLEQLLVVDLSGNQLTSNHVDNTTFAGLIRLIVLNLAHNALTRIDYRTFKELYFLQILNLRNN 404

  Fly   243 ------------LTNVQNLVLEGSSLSSL---VINGGFI--KLQAGNNELNHLQVG---NKSSVI 287
                        |.|:..|.|..:.|.:|   :.||.::  ||...||.::.::..   |.|.:.
  Fly   405 SIGHIEDNAFLPLYNLHTLNLAENRLHTLDDKLFNGLYVLSKLTLNNNLISVVEPAVFKNCSDLK 469

  Fly   288 EMDLHGNLLNGNDTAALLRGMWNLQRLDLSKNRIEALPQHG-------SGLDASGTQ--ELLI-- 341
            |:||..|.|  |:....|:.:..|:.|||.:|:|.......       :||.....|  .:.:
  Fly   470 ELDLSSNQL--NEVPRALQDLAMLRTLDLGENQIRTFDNQSFKNLHQLTGLRLIDNQIGNITVGM 532

  Fly   342 ---LPSLKFLNLANNQL----------------VRLPPE---------SPILSSRLSYLDLSHNL 378
               ||.|..||||.|::                :||...         :.::|  |.:|:||.|.
  Fly   533 FQDLPRLSVLNLAKNRIQSIERGSFDKNFELEAIRLDRNFLADINGVFATLVS--LLWLNLSENH 595

  Fly   379 MLTLDVAILRSLSVLKGLYVEGNRLNTI-NYQKLHEE---------HPDLSELGLHDNPWSSGLY 433
            ::..|.|.:.  |.||.|.:.||.:..: ||.||.||         |..::|:|    |.|  :.
  Fly   596 LVWFDYAFIP--SNLKWLDIHGNYIEALGNYYKLQEEIRVKTLDASHNRITEIG----PMS--IP 652

  Fly   434 RKMFLYFTDRGVHLQARPQNRVLNKSSRVDIDWPPNE 470
            ..:.|.|.:..:....:| |..::|::...:|...|:
  Fly   653 NTIELLFINNNLIGNVQP-NAFVDKANLARVDLYANQ 688

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG18249	NP_001163549.1	leucine-rich repeat	57..80	CDD:275380	7/26 (27%)
		LRR	105..433	CDD:443914	114/472 (24%)
		leucine-rich repeat	105..128	CDD:275380	6/22 (27%)
		leucine-rich repeat	129..152	CDD:275380	8/54 (15%)
		leucine-rich repeat	153..176	CDD:275380	8/25 (32%)
		leucine-rich repeat	177..200	CDD:275380	10/22 (45%)
		leucine-rich repeat	201..224	CDD:275380	8/48 (17%)
		leucine-rich repeat	225..258	CDD:275380	12/59 (20%)
		leucine-rich repeat	259..310	CDD:275380	16/58 (28%)
		leucine-rich repeat	311..344	CDD:275380	10/46 (22%)
		leucine-rich repeat	345..368	CDD:275380	9/47 (19%)
		leucine-rich repeat	369..390	CDD:275380	7/20 (35%)
		leucine-rich repeat	393..417	CDD:275380	12/33 (36%)
Toll-7	NP_523797.1	LRR	45..473	CDD:443914	92/392 (23%)
		leucine-rich repeat	136..159	CDD:275380	9/29 (31%)
		leucine-rich repeat	160..190	CDD:275380	4/29 (14%)
		leucine-rich repeat	191..214	CDD:275380	6/22 (27%)
		leucine-rich repeat	215..248	CDD:275380	7/32 (22%)
		leucine-rich repeat	249..273	CDD:275380	3/23 (13%)
		leucine-rich repeat	274..297	CDD:275380	6/22 (27%)
		leucine-rich repeat	298..321	CDD:275380	10/22 (45%)
		leucine-rich repeat	322..345	CDD:275380	4/22 (18%)
		leucine-rich repeat	346..371	CDD:275380	4/24 (17%)
		LRR	369..>675	CDD:443914	77/318 (24%)
		leucine-rich repeat	372..395	CDD:275380	5/22 (23%)
		leucine-rich repeat	396..419	CDD:275380	3/22 (14%)
		leucine-rich repeat	420..443	CDD:275380	6/22 (27%)
		leucine-rich repeat	444..467	CDD:275380	5/22 (23%)
		leucine-rich repeat	468..488	CDD:275380	7/21 (33%)
		leucine-rich repeat	491..514	CDD:275380	6/22 (27%)
		leucine-rich repeat	515..536	CDD:275380	3/20 (15%)
		leucine-rich repeat	539..562	CDD:275380	6/22 (27%)
		leucine-rich repeat	563..585	CDD:275380	2/21 (10%)
		leucine-rich repeat	586..626	CDD:275380	15/41 (37%)
		leucine-rich repeat	627..653	CDD:275380	8/31 (26%)
		LRRCT	716..772	CDD:214507
		LRR	<812..>963	CDD:443914
		leucine-rich repeat	812..829	CDD:275380
		leucine-rich repeat	833..854	CDD:275380
		leucine-rich repeat	855..878	CDD:275380
		leucine-rich repeat	879..902	CDD:275380
		leucine-rich repeat	903..926	CDD:275380
		leucine-rich repeat	927..953	CDD:275380
		TIR	1098..1235	CDD:214587