DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG18249 and CG4168

DIOPT Version :9

Sequence 1:NP_001163549.1 Gene:CG18249 / 40964 FlyBaseID:FBgn0037553 Length:559 Species:Drosophila melanogaster
Sequence 2:NP_001285953.1 Gene:CG4168 / 34889 FlyBaseID:FBgn0028888 Length:1330 Species:Drosophila melanogaster


Alignment Length:657 Identity:145/657 - (22%)
Similarity:246/657 - (37%) Gaps:173/657 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MHFYKYILLGICGLTVSDALAVYDASGRFNLSASCPDSFCSLSDRPVAYSATPALQLR---ELHL 62
            :|..||:.|      .|:.::      :.|...|..::...||.....:|..|.|.|:   :|..
  Fly   434 LHHLKYLYL------TSNQIS------QLNNLPSFTENLRVLSLSGNNFSMIPVLGLKNYTQLSY 486

  Fly    63 RNCSRQSIT------WLVLQLTPGLRTLVIRNCATYHISKESLRPVENLTSLQMQGTSLGVLRDQ 121
            .|....|||      :.|......|:|:::||....|:...|...:|.:..:.:....:.:....
  Fly   487 LNMGYNSITDIPEGIFAVDSWGSNLQTILLRNNKITHLHLGSFAGLEQIQEISLSFNDITIHHPL 551

  Fly   122 IFNAVPR-LEILQLS------QNFIHTVHVAAFQGLSKLRLLGLQGNAIAEILSSTLDPLMELVH 179
            :|..|.| |:||:||      ::......:.|...||:|..|||..|.:.::.:.:...:.||.:
  Fly   552 VFENVSRTLKILELSFAVFPARSLESLDPLDALLPLSQLIWLGLDNNNLKQVSNESFAQMRELSY 616

  Fly   180 LDLSRNELTTLPQNIFAKNK--------------------------KLQTLLLNGNPLRILMPDV 218
            ::||.|:|.|||:.:|..:.                          .||||.|..|.||.:....
  Fly   617 INLSFNQLKTLPRGLFQSDAHSHLVEIDLSYNGLERLEAQTFHSLGDLQTLNLQSNRLRTIARHA 681

  Fly   219 LGSLPNLRLLDLGHAAELEV----MTLNLTNVQNLVLEGSSLSSLVINGGFIKLQAGNNEL---- 275
            ..:|..||.|||.:...:.:    .|: |.|:..|.|..:.|.||.:. .|:.:......|    
  Fly   682 FHNLEFLRYLDLSYNRLVNISHGAFTV-LPNLAALDLMHNQLCSLSLK-SFLYVSNTTTPLRLNV 744

  Fly   276 --NHL-----QVGNKSSVIEMDLHGNLLNGNDTAALLRGMWNLQRLDLSKNRIEALPQHGSGLDA 333
              ||:     ::.:...:.::|:..|.:..:|:...|..  .|:.|:|:.|::.:|..|..|   
  Fly   745 SHNHIASFYDELSSYMYIYQLDISHNHVTKSDSFTNLAN--TLRFLNLAHNQLGSLQSHAFG--- 804

  Fly   334 SGTQELLILPSLKFLNLANNQLVRLPPESPILSSRLSYLDLSHNLMLTLDVAILRSLSVLKGLYV 398
                   .|..|:.||:|:|.|..|...|....:.|..||||||.:..|.|....:|..|:.|.:
  Fly   805 -------DLEFLEILNVAHNNLTSLRRRSFQGLNSLQELDLSHNQLDQLQVEQFSNLRKLRILRI 862

  Fly   399 EGNRL---------NT-INYQKLHEEH------PDLSELGL--------HDNPWSSGLYRKMFLY 439
            ..|||         || :.:..:.|..      |..:::|.        |:|           |.
  Fly   863 NSNRLRALPREVFMNTRLEFLDIAENQLSVWPVPAFTDIGFTLRSIQMSHNN-----------LE 916

  Fly   440 FTDRGVHLQAR-------PQNRV----------LNKSSRVDIDWPPNEGQAEAQKMDPPGVTGIH 487
            :.|..:.:.::       .:||:          ||..:.:|:.             ..|.||   
  Fly   917 YLDASMFINSQFLYDISLARNRITILPDNTFSFLNNLTNLDLS-------------QNPLVT--- 965

  Fly   488 PYWTLRDILAFVTLLVVMIILLMNLYHI--------------------LEEEGCLRRFRHWRRSR 532
              ..||::......|..:.:..|.||.:                    |...|.||..||...|.
  Fly   966 --TNLREVFVHTPRLRKLSLHHMGLYVLPPLKLPLLSYLDVSGNYLQELSPLGSLRHLRHVNVSH 1028

  Fly   533 TLGQNTS 539
            ....|.|
  Fly  1029 NKLTNAS 1035

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG18249NP_001163549.1 leucine-rich repeat 57..80 CDD:275380 7/31 (23%)
LRR_8 104..163 CDD:290566 16/65 (25%)
leucine-rich repeat 105..128 CDD:275380 2/22 (9%)
LRR_RI 107..438 CDD:238064 94/402 (23%)
leucine-rich repeat 129..152 CDD:275380 7/28 (25%)
leucine-rich repeat 153..176 CDD:275380 5/22 (23%)
LRR_8 176..232 CDD:290566 24/81 (30%)
leucine-rich repeat 177..200 CDD:275380 9/48 (19%)
leucine-rich repeat 201..224 CDD:275380 9/22 (41%)
leucine-rich repeat 225..258 CDD:275380 11/36 (31%)
leucine-rich repeat 259..310 CDD:275380 9/61 (15%)
leucine-rich repeat 311..344 CDD:275380 8/32 (25%)
LRR_8 343..403 CDD:290566 21/59 (36%)
leucine-rich repeat 345..368 CDD:275380 8/22 (36%)
leucine-rich repeat 369..390 CDD:275380 9/20 (45%)
leucine-rich repeat 393..417 CDD:275380 8/39 (21%)
CG4168NP_001285953.1 leucine-rich repeat 99..118 CDD:275380
LRR_8 121..181 CDD:290566
LRR_RI 122..350 CDD:238064
leucine-rich repeat 122..146 CDD:275380
leucine-rich repeat 147..170 CDD:275380
leucine-rich repeat 171..194 CDD:275380
leucine-rich repeat 195..214 CDD:275380
leucine-rich repeat 215..236 CDD:275380
LRR_8 265..322 CDD:290566
leucine-rich repeat 266..287 CDD:275380
leucine-rich repeat 288..311 CDD:275380
leucine-rich repeat 312..338 CDD:275380
LRR_RI 315..546 CDD:238064 26/123 (21%)
leucine-rich repeat 339..365 CDD:275380
LRR_8 365..424 CDD:290566
leucine-rich repeat 366..388 CDD:275380
leucine-rich repeat 389..412 CDD:275380
LRR_8 413..470 CDD:290566 9/47 (19%)
leucine-rich repeat 414..436 CDD:275380 0/1 (0%)
leucine-rich repeat 437..459 CDD:275380 6/33 (18%)
leucine-rich repeat 460..483 CDD:275380 6/22 (27%)
LRR_8 482..545 CDD:290566 13/62 (21%)
leucine-rich repeat 484..510 CDD:275380 6/25 (24%)
leucine-rich repeat 511..534 CDD:275380 6/22 (27%)
leucine-rich repeat 535..589 CDD:275380 10/53 (19%)
LRR_RI 588..891 CDD:238064 80/316 (25%)
LRR_8 588..650 CDD:290566 16/61 (26%)
leucine-rich repeat 590..613 CDD:275380 5/22 (23%)
leucine-rich repeat 614..639 CDD:275380 9/24 (38%)
LRR_8 638..698 CDD:290566 14/59 (24%)
leucine-rich repeat 640..663 CDD:275380 0/22 (0%)
leucine-rich repeat 664..687 CDD:275380 9/22 (41%)
LRR_8 688..749 CDD:290566 16/62 (26%)
leucine-rich repeat 688..711 CDD:275380 7/23 (30%)
leucine-rich repeat 712..735 CDD:275380 6/23 (26%)
leucine-rich repeat 740..783 CDD:275380 7/42 (17%)
LRR_8 784..843 CDD:290566 23/68 (34%)
leucine-rich repeat 785..808 CDD:275380 8/32 (25%)
leucine-rich repeat 809..832 CDD:275380 8/22 (36%)
LRR_RI <827..1053 CDD:238064 47/238 (20%)
LRR_8 832..890 CDD:290566 18/57 (32%)
leucine-rich repeat 833..856 CDD:275380 10/22 (45%)
leucine-rich repeat 857..879 CDD:275380 6/21 (29%)
leucine-rich repeat 880..900 CDD:275380 2/19 (11%)
LRR_8 904..963 CDD:290566 9/82 (11%)
leucine-rich repeat 905..928 CDD:275380 4/33 (12%)
leucine-rich repeat 929..952 CDD:275380 3/22 (14%)
leucine-rich repeat 953..977 CDD:275380 6/41 (15%)
leucine-rich repeat 978..1020 CDD:275380 7/41 (17%)
LRR_8 1019..1074 CDD:290566 6/17 (35%)
leucine-rich repeat 1045..1068 CDD:275380
leucine-rich repeat 1069..1090 CDD:275380
leucine-rich repeat 1091..1114 CDD:275380
leucine-rich repeat 1115..1161 CDD:275380
leucine-rich repeat 1162..1190 CDD:275380
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45453645
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
21.840

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