DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18249 and IGFALS

DIOPT Version :9

Sequence 1:	NP_001163549.1	Gene:	CG18249 / 40964	FlyBaseID:	FBgn0037553	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	NP_001139478.1	Gene:	IGFALS / 3483	HGNCID:	5468	Length:	643	Species:	Homo sapiens

Alignment Length:	550	Identity:	145/550 - (26%)
Similarity:	212/550 - (38%)	Gaps:	121/550 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 NLSASCPDSFCSLSDRPVAYSATPALQLRELHLRNCSRQSITWLVLQLTPGLRTLVIRNCATYHI 94
            |||:..|.:|.:|       |:...|.|:...|.:...|::             |.:.|....|:
Human   123 NLSSVPPAAFQNL-------SSLGFLNLQGGQLGSLEPQAL-------------LGLENLCHLHL 167

  Fly    95 SKESLRPV--------ENLTSLQMQGTSLGVLRDQIFNAVPRLEILQLSQNFIHTVHVAAFQGLS 151
            .:..||.:        ..|.||.:....|..|.|.:|..:..|..|.|..|.:..:..|||:||.
Human   168 ERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLG 232

  Fly   152 KLRLLGLQGNAIAEILSSTLDPLMELVHLDLSRNELTTLPQNIFAKNKKLQTLLLNGNPLRILMP 216
            .||.|.|.||.:|.:..:....|.||..||||||.|..:..|:|.:..:||.|.|:.|.:..:.|
Human   233 SLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAP 297

  Fly   217 DVLGSLPNLRLLDLGH---AAELEVMTLNLTNVQNLVLEGSSLSSL----VINGGFI-KLQAGNN 273
            .....|..||.|||.|   |..||.....|..::.|.|..::::||    ..:..|: :||.|:|
Human   298 GAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHN 362

  Fly   274 ELNHLQVGNKSSVIEMD---LHGNLLNGNDTAALLRGMWNLQRLDLSKNRIEALPQ--------- 326
            .:..|...:...:.:::   |..|.|......|.| |:.|:..::||.|.:..||:
Human   363 RIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFL-GLTNVAVMNLSGNCLRNLPEQVFRGLGKL 426

  Fly   327 HGSGLDAS-----------------------------------GTQELLILP------------- 343
            |...|:.|                                   |..|||.|.
Human   427 HSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRL 491

  Fly   344 -----SLKFLNLANNQLVRLPPESPILSSRLSYLDLSHNLMLTLDVAILRSLSVLKGLYVEGNRL 403
                 .|::|.|:.|:|..||.::.....|..:||:|||.:..|..::|..|..|:.|.:..|.|
Human   492 FQGLGKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSL 556

  Fly   404 NTINYQKLHEEHPDLSELGLHDNPWSSGLYRKMFLYFTDRGVHLQ---ARPQNRVLNKSSRVDID 465
            .|...|.     |.|..|.|..|||..|...|..     |...||   |.|  |.:......|..
Human   557 RTFTPQP-----PGLERLWLEGNPWDCGCPLKAL-----RDFALQNPSAVP--RFVQAICEGDDC 609

  Fly   466 WPPNEGQAEAQKMDPPGVTGIHPYWTLRDI 495
            .||...........||.|.|:    .|||:
Human   610 QPPAYTYNNITCASPPEVVGL----DLRDL 635

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18249	NP_001163549.1	leucine-rich repeat	57..80	CDD:275380	3/22 (14%)
		LRR_8	104..163	CDD:290566	22/58 (38%)
		leucine-rich repeat	105..128	CDD:275380	7/22 (32%)
		LRR_RI	107..438	CDD:238064	112/403 (28%)
		leucine-rich repeat	129..152	CDD:275380	9/22 (41%)
		leucine-rich repeat	153..176	CDD:275380	8/22 (36%)
		LRR_8	176..232	CDD:290566	23/55 (42%)
		leucine-rich repeat	177..200	CDD:275380	10/22 (45%)
		leucine-rich repeat	201..224	CDD:275380	7/22 (32%)
		leucine-rich repeat	225..258	CDD:275380	12/35 (34%)
		leucine-rich repeat	259..310	CDD:275380	13/58 (22%)
		leucine-rich repeat	311..344	CDD:275380	13/94 (14%)
		LRR_8	343..403	CDD:290566	19/77 (25%)
		leucine-rich repeat	345..368	CDD:275380	7/22 (32%)
		leucine-rich repeat	369..390	CDD:275380	7/20 (35%)
		leucine-rich repeat	393..417	CDD:275380	6/23 (26%)
IGFALS	NP_001139478.1	LRRNT	78..116	CDD:214470
		leucine-rich repeat	95..113	CDD:275380
		leucine-rich repeat	114..137	CDD:275380	6/20 (30%)
		leucine-rich repeat	138..161	CDD:275380	5/35 (14%)
		LRR_8	141..196	CDD:290566	12/67 (18%)
		leucine-rich repeat	162..185	CDD:275380	3/22 (14%)
		LRR_8	184..244	CDD:290566	22/59 (37%)
		leucine-rich repeat	186..209	CDD:275380	7/22 (32%)
		leucine-rich repeat	210..233	CDD:275380	9/22 (41%)
		leucine-rich repeat	234..257	CDD:275380	8/22 (36%)
		LRR_8	257..316	CDD:290566	24/58 (41%)
		leucine-rich repeat	258..281	CDD:275380	10/22 (45%)
		leucine-rich repeat	282..305	CDD:275380	7/22 (32%)
		leucine-rich repeat	306..324	CDD:275380	9/17 (53%)
		LRR_8	336..388	CDD:290566	10/51 (20%)
		leucine-rich repeat	354..377	CDD:275380	5/22 (23%)
		LRR_8	377..433	CDD:290566	14/56 (25%)
		leucine-rich repeat	378..401	CDD:275380	6/23 (26%)
		leucine-rich repeat	402..423	CDD:275380	5/20 (25%)
		LRR_8	425..484	CDD:290566	8/58 (14%)
		leucine-rich repeat	426..447	CDD:275380	3/20 (15%)
		leucine-rich repeat	450..473	CDD:275380	1/22 (5%)
		leucine-rich repeat	474..497	CDD:275380	3/22 (14%)
		LRR_8	476..532	CDD:290566	14/55 (25%)
		leucine-rich repeat	498..519	CDD:275380	7/20 (35%)
		leucine-rich repeat	522..543	CDD:275380	7/20 (35%)
		LRR_8	524..575	CDD:290566	18/55 (33%)
		leucine-rich repeat	546..565	CDD:275380	6/23 (26%)
		TPKR_C2	574..618	CDD:301599	14/50 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910