DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18249 and CG16974

DIOPT Version :9

Sequence 1:	NP_001163549.1	Gene:	CG18249 / 40964	FlyBaseID:	FBgn0037553	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	NP_001246018.1	Gene:	CG16974 / 34713	FlyBaseID:	FBgn0032479	Length:	1257	Species:	Drosophila melanogaster

Alignment Length:	402	Identity:	102/402 - (25%)
Similarity:	162/402 - (40%)	Gaps:	80/402 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 RPVAYSATPALQLRELHLRNCSRQSITWLVLQLTPGLRTLVIRNCATYHISKESLRPVENLTSLQ 109
            :|.::.....|.|.|..|     :.:.|.:......::.|.:......:.|..:|:.::.|..|.
  Fly   198 QPRSFEYMERLNLAENRL-----ECLHWAIPLAVRRVKVLEMSGNRLSNCSLLNLQYMKQLQELH 257

  Fly   110 MQGTSLGVLRDQIFNAVPRLEILQLSQNFIHTVHVAAFQGLSKLRLLGLQGNAIAEILSSTLDPL 174
            :..:.|..|..:....:..|.:|.||||.:..:....|.|..||..|.|.||.::.:........
  Fly   258 LDRSELTYLPQRFLGELSELRMLNLSQNLLTELPRDIFVGALKLERLYLSGNRLSVLPFMLFQTA 322

  Fly   175 MELVHLDLSRNELTTLPQNIFAKNKKLQTLLLNGNPLRILMPDVLGSLPNLRLLDLGHAAELEVM 239
            .:|..||||.|.|.:.|.|.||:|.:|:.|.|..|.|:.:....|.||..||.|||.
  Fly   323 ADLQVLDLSDNRLLSFPDNFFARNGQLRQLHLQRNQLKSIGKHSLYSLRELRQLDLS-------- 379

  Fly   240 TLNLTNVQN--LVLEGSSLSSLVINGGFIKLQAGNNELNHLQVGNKSSVIEMDLHGNLLNGNDTA 302
                   ||  .|::..:..||   ...:.|....|.|..|     ||:|...||.
  Fly   380 -------QNSLSVIDRKAFESL---DHLLALNVSGNNLTLL-----SSIIFQSLHA--------- 420

  Fly   303 ALLRGMWNLQRLDLSKNRIEALPQHGSGL------------DASGTQEL--------------LI 341
                    |::||||:|:.:.||   |||            |.:..::.              .:
  Fly   421 --------LRQLDLSRNQFKQLP---SGLFQRQRSLVLLRIDETPIEQFSNWISRYDESLVDPQV 474

  Fly   342 LPSLKFLNL-ANNQLVRLPPESPILSSRLSYLDLSHNLMLTLDVAILRSLSVLKGLYVEGNRLNT 405
            |..|::|:: .|.:|..||......:..:..|.|:.|.:|.|...| ..||.|:.|.|.||.|.:
  Fly   475 LHRLRYLSVQQNRKLTYLPATLFANTPNIRELLLAENGLLQLPTQI-SGLSRLQRLSVRGNSLGS 538

  Fly   406 I--NYQKLHEEH 415
            :  |.::|.:.|
  Fly   539 LPENIKELRQLH 550

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18249	NP_001163549.1	leucine-rich repeat	57..80	CDD:275380	4/22 (18%)
		LRR_8	104..163	CDD:290566	18/58 (31%)
		leucine-rich repeat	105..128	CDD:275380	4/22 (18%)
		LRR_RI	107..438	CDD:238064	92/340 (27%)
		leucine-rich repeat	129..152	CDD:275380	8/22 (36%)
		leucine-rich repeat	153..176	CDD:275380	5/22 (23%)
		LRR_8	176..232	CDD:290566	25/55 (45%)
		leucine-rich repeat	177..200	CDD:275380	12/22 (55%)
		leucine-rich repeat	201..224	CDD:275380	8/22 (36%)
		leucine-rich repeat	225..258	CDD:275380	8/34 (24%)
		leucine-rich repeat	259..310	CDD:275380	10/50 (20%)
		leucine-rich repeat	311..344	CDD:275380	13/58 (22%)
		LRR_8	343..403	CDD:290566	19/60 (32%)
		leucine-rich repeat	345..368	CDD:275380	6/23 (26%)
		leucine-rich repeat	369..390	CDD:275380	6/20 (30%)
		leucine-rich repeat	393..417	CDD:275380	9/25 (36%)
CG16974	NP_001246018.1	leucine-rich repeat	206..228	CDD:275380	5/26 (19%)
		leucine-rich repeat	229..252	CDD:275380	3/22 (14%)
		LRR_RI	<246..433	CDD:238064	64/226 (28%)
		LRR_8	251..311	CDD:290566	18/59 (31%)
		leucine-rich repeat	253..276	CDD:275380	4/22 (18%)
		leucine-rich repeat	277..300	CDD:275380	8/22 (36%)
		leucine-rich repeat	301..324	CDD:275380	5/22 (23%)
		LRR_8	325..383	CDD:290566	27/72 (38%)
		leucine-rich repeat	325..348	CDD:275380	12/22 (55%)
		leucine-rich repeat	349..372	CDD:275380	8/22 (36%)
		LRR_RI	351..>557	CDD:238064	62/244 (25%)
		LRR_8	371..431	CDD:290566	25/99 (25%)
		leucine-rich repeat	373..396	CDD:275380	10/40 (25%)
		leucine-rich repeat	397..420	CDD:275380	8/27 (30%)
		leucine-rich repeat	421..444	CDD:275380	11/25 (44%)
		LRR_8	477..536	CDD:290566	19/59 (32%)
		leucine-rich repeat	478..502	CDD:275380	6/23 (26%)
		leucine-rich repeat	503..526	CDD:275380	8/23 (35%)
		Ig	<714..761	CDD:299845
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453816
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840