DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18249 and Toll-4

DIOPT Version :9

Sequence 1:	NP_001163549.1	Gene:	CG18249 / 40964	FlyBaseID:	FBgn0037553	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	NP_523519.2	Gene:	Toll-4 / 34235	FlyBaseID:	FBgn0032095	Length:	1125	Species:	Drosophila melanogaster

Alignment Length:	487	Identity:	102/487 - (20%)
Similarity:	168/487 - (34%)	Gaps:	182/487 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    81 LRTLVIRNCATYHISKESLRPVENLTSLQMQGTSLGVLRDQIFNAVPRLEILQLSQ-----NFI- 139
            ||:..:::..||.|.|     |:|:..|:.            |.....|||:::||     ||.
  Fly   304 LRSSTLQSSLTYCIMK-----VDNMVDLKS------------FEKFTNLEIIEVSQYKGFKNFTA 351

  Fly   140 -----HTVHVAAFQGL-----------------SKLRL----------------------LGLQG 160
                 :..|.....|:                 |:|.:                      |..|.
  Fly   352 FICEPYKSHCKFTLGINEVACPLKCNCSYNRDKSQLEIDCWQKNLTTIPSLPVPKKGSSALVFQS 416

  Fly   161 NAIAEILSSTLDPLMELVHLDLSRNELTTLPQNIFAKNKKLQTLLLNGNPLRILMPDVLGSLPNL 225
            |.:||:..::|:....|..||:|.|:||:|  ::....:.|..|.:..|.:..|.|.|:..|.::
  Fly   417 NLLAELPDNSLEGYHNLKSLDVSYNQLTSL--SVSQLPESLHYLDIRHNKITTLSPQVVEYLYSV 479

  Fly   226 RLL-----------DLGHAAEL-----EVMTLNLTNVQNLV--LEGSSLSSLVINGGFIK----- 267
            .:.           |..|..|.     :::.:..:..|.::  :|.||..|.|.| .|::
  Fly   480 NVFNQYGNKWSIYCDEYHLQEFFWYKAKLLRIKTSKFQTIMEYIELSSKGSFVEN-FFVQNIDQL 543

  Fly   268 -LQAGNNE-------------------LNH---LQVGNKSSVIEMDLHGNLLNGN---------- 299
             |:|..:|                   |||   |..|....:|   ||.  ||..
  Fly   544 YLEANEDEIIDAFGPSDKYFNLKLMEALNHAIWLFSGEFDEII---LHH--LNSPCPYRCSCCFE 603

  Fly   300 -DTAALLRGMWNLQ---------------RLDLSKNRIEALPQHGSGLDASGTQELLIL--PSLK 346
             .|...|....||.               .|.|.:|.|..|         :.|:.|::.  .|:.
  Fly   604 WHTGEFLINCRNLSLDIYPRLPNSIPYKTTLYLDRNEIRKL---------TNTESLVVAGHASIH 659

  Fly   347 FLNLANNQLVRLPPESPILSSRLSYLDLSHNLMLTLDVAILRSLSVLKGLYVEGNRLNTINYQKL 411
            .|:::.|.|..||..  :|...::|||:.:||:..||..::..|
  Fly   660 KLHMSQNLLRELPLH--LLPENITYLDVRNNLLKYLDDGVIAFL--------------------- 701

  Fly   412 HEEHPDLSELGLHDNPWSSGLYRKMFLYFTDR 443
             |...:::::.|..|||......|.||.|..|
  Fly   702 -EYRENITKIELSGNPWECNCKAKAFLSFLRR 732

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18249	NP_001163549.1	leucine-rich repeat	57..80	CDD:275380
		LRR_8	104..163	CDD:290566	17/108 (16%)
		leucine-rich repeat	105..128	CDD:275380	2/22 (9%)
		LRR_RI	107..438	CDD:238064	90/454 (20%)
		leucine-rich repeat	129..152	CDD:275380	9/50 (18%)
		leucine-rich repeat	153..176	CDD:275380	7/44 (16%)
		LRR_8	176..232	CDD:290566	16/66 (24%)
		leucine-rich repeat	177..200	CDD:275380	8/22 (36%)
		leucine-rich repeat	201..224	CDD:275380	7/22 (32%)
		leucine-rich repeat	225..258	CDD:275380	7/50 (14%)
		leucine-rich repeat	259..310	CDD:275380	18/89 (20%)
		leucine-rich repeat	311..344	CDD:275380	8/49 (16%)
		LRR_8	343..403	CDD:290566	15/59 (25%)
		leucine-rich repeat	345..368	CDD:275380	6/22 (27%)
		leucine-rich repeat	369..390	CDD:275380	7/20 (35%)
		leucine-rich repeat	393..417	CDD:275380	1/23 (4%)
Toll-4	NP_523519.2	leucine-rich repeat	264..287	CDD:275380
		leucine-rich repeat	288..308	CDD:275380	2/3 (67%)
		leucine-rich repeat	309..334	CDD:275380	8/41 (20%)
		leucine-rich repeat	335..386	CDD:275380	9/50 (18%)
		leucine-rich repeat	388..408	CDD:275380	0/19 (0%)
		LRR_8	412..465	CDD:290566	17/54 (31%)
		leucine-rich repeat	412..432	CDD:275378	6/19 (32%)
		LRR_4	432..470	CDD:289563	12/39 (31%)
		leucine-rich repeat	433..454	CDD:275378	8/22 (36%)
		leucine-rich repeat	455..478	CDD:275378	7/22 (32%)
		leucine-rich repeat	479..490	CDD:275378	0/10 (0%)
		leucine-rich repeat	632..657	CDD:275378	7/33 (21%)
		leucine-rich repeat	658..679	CDD:275378	6/22 (27%)
		leucine-rich repeat	680..706	CDD:275378	9/47 (19%)
		leucine-rich repeat	707..719	CDD:275378	4/11 (36%)
		leucine-rich repeat	771..791	CDD:275380
		leucine-rich repeat	793..815	CDD:275378
		leucine-rich repeat	816..835	CDD:275378
		leucine-rich repeat	836..859	CDD:275378
		TIR	974..1110	CDD:214587
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453779
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930