DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18249 and si:dkey-182i3.11

DIOPT Version :9

Sequence 1:	NP_001163549.1	Gene:	CG18249 / 40964	FlyBaseID:	FBgn0037553	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	XP_021322095.1	Gene:	si:dkey-182i3.11 / 100334238	ZFINID:	ZDB-GENE-121214-258	Length:	710	Species:	Danio rerio

Alignment Length:	526	Identity:	134/526 - (25%)
Similarity:	222/526 - (42%)	Gaps:	115/526 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 LAVYDASGRFNLSASCPDSFCSLSDRPVAYSATPALQLRELHLRNCSRQSITWLVLQLTPGLRTL 84
            |.|.|.|.  |...|.|..|        .|.   .:.|:.|:|......|:::.||:....|..|
Zfish   153 LQVLDLSN--NAIKSLPQMF--------LYG---LINLQTLNLNINQILSLSYGVLEGPLALTDL 204

  Fly    85 VIR-------------NC---ATYHISKESLRPV------------------------------- 102
            .:|             ||   |..::||..|:.|
Zfish   205 QLRDNMIDMIEMNVFENCTYLAKLYLSKNKLKSVGNGSFKGATGLNHLDLGLNGLAGIPTIVLQE 269

  Fly   103 -ENLTSLQMQGTSLGVLRDQIFNAVPRLEILQLSQNFIHTVHVAAFQGLSKLRLLGLQGNAIAEI 166
             .|||||.:|...:..:.|.:|:.:..|:.|.||.|.:.::...:|:.||:|..|.|..|.:..:
Zfish   270 TSNLTSLYLQKNDITSIPDNVFSEILSLKHLDLSYNGLVSISNGSFRSLSQLVYLDLSFNQLQTL 334

  Fly   167 LSSTLDPLMELVHLDLSRNELTTLPQNIFAKNKKLQTLLLNGNPLRILMPDV---LGSLPNLRLL 228
            .....:.|.:|.:|:|..|:||:||.|:|.....|:.|.|:.|.:.::.||:   |.:|.:|: |
Zfish   335 TQHVFEDLGKLENLNLYHNKLTSLPNNMFKNLTMLKELQLDSNNISVIPPDLFHPLSALKDLQ-L 398

  Fly   229 DLGHAAELEVMTL-NLTNVQNLVLEGSSLSSLVINGGFIK-LQAGNNELNHLQVGNKSSVIEMD- 290
            |..|.::|...|. .|..::.|.:..:.|:. :.|..|.| |:..|.|.||:...:|.|...:.
Zfish   399 DNNHISKLHSHTFKKLRQLKQLDISSNDLTK-IPNHLFHKNLKELNLENNHISFISKFSFKNLHR 462

  Fly   291 LHGNLLNGNDTAALLR----GMWNLQRLDLSKNRIEALP-QHGSGLDASGTQELLILPSLKFLNL 350
            |....|:.|:.:.|.|    .:..|:.|.|::|:||.:| ....||:           :|:.|:|
Zfish   463 LQSLKLSHNNLSKLYRELLTNLTRLRELLLNENQIETIPVGFFKGLE-----------NLRVLDL 516

  Fly   351 ANNQLVRLPPESPILSSRLSYLDLSHNLMLTLDVAILRSLSVLKGLYVEGNRLN---------TI 406
            :||::..:.|::....|.|..||||.|.:..|...|..||..|..|:::.|:|.         .:
Zfish   517 SNNKMHFILPDAFNDLSALKDLDLSFNFLHNLPEDIFASLRNLTKLHLQNNKLRYLPSRLFSALV 581

  Fly   407 NYQKLHEE-------HPDLSE--LGLHDNPWSSGLYRKMFLYFTDRGVHLQARPQNRVLNKSSRV 462
            ..::||.:       ||...|  :.||:....|...|.|     :.|..:.       |.|..|:
Zfish   582 GLEELHLDRNYIQRIHPTQFEGLVKLHELDMKSNQLRSM-----EDGTLMP-------LRKLKRI 634

  Fly   463 DIDWPP 468
            .:|..|
Zfish   635 HLDGNP 640

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18249	NP_001163549.1	leucine-rich repeat	57..80	CDD:275380	6/22 (27%)
		LRR_8	104..163	CDD:290566	20/58 (34%)
		leucine-rich repeat	105..128	CDD:275380	7/22 (32%)
		LRR_RI	107..438	CDD:238064	100/359 (28%)
		leucine-rich repeat	129..152	CDD:275380	7/22 (32%)
		leucine-rich repeat	153..176	CDD:275380	5/22 (23%)
		LRR_8	176..232	CDD:290566	21/58 (36%)
		leucine-rich repeat	177..200	CDD:275380	10/22 (45%)
		leucine-rich repeat	201..224	CDD:275380	8/25 (32%)
		leucine-rich repeat	225..258	CDD:275380	9/33 (27%)
		leucine-rich repeat	259..310	CDD:275380	15/56 (27%)
		leucine-rich repeat	311..344	CDD:275380	9/33 (27%)
		LRR_8	343..403	CDD:290566	20/59 (34%)
		leucine-rich repeat	345..368	CDD:275380	6/22 (27%)
		leucine-rich repeat	369..390	CDD:275380	8/20 (40%)
		leucine-rich repeat	393..417	CDD:275380	7/39 (18%)
si:dkey-182i3.11	XP_021322095.1	PLN00113	97..>617	CDD:331614	126/489 (26%)
		leucine-rich repeat	129..152	CDD:275380
		leucine-rich repeat	153..176	CDD:275380	9/35 (26%)
		leucine-rich repeat	177..200	CDD:275380	6/22 (27%)
		leucine-rich repeat	201..224	CDD:275380	5/22 (23%)
		leucine-rich repeat	225..248	CDD:275380	5/22 (23%)
		leucine-rich repeat	249..272	CDD:275380	0/22 (0%)
		leucine-rich repeat	273..296	CDD:275380	7/22 (32%)
		leucine-rich repeat	297..320	CDD:275380	7/22 (32%)
		leucine-rich repeat	321..344	CDD:275380	5/22 (23%)
		leucine-rich repeat	345..368	CDD:275380	10/22 (45%)
		leucine-rich repeat	369..392	CDD:275380	7/22 (32%)
		leucine-rich repeat	393..438	CDD:275380	12/46 (26%)
		leucine-rich repeat	417..436	CDD:275380	3/19 (16%)
		leucine-rich repeat	439..462	CDD:275380	7/22 (32%)
		leucine-rich repeat	463..486	CDD:275380	5/22 (23%)
		leucine-rich repeat	487..510	CDD:275380	9/33 (27%)
		leucine-rich repeat	511..534	CDD:275380	6/22 (27%)
		leucine-rich repeat	535..558	CDD:275380	10/22 (45%)
		leucine-rich repeat	559..582	CDD:275380	4/22 (18%)
		leucine-rich repeat	583..606	CDD:275380	5/22 (23%)
		leucine-rich repeat	607..628	CDD:275380	6/32 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910